Background: Kisspeptin the product of the gene Kiss1 is a G-protein coupled receptor legend for GPR54. Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. It is recently become clear that kisspeptin-GPR54 signaling has an important role in initiating GnRH secretion at puberty, the extent of which is an area of ongoing research.
Objective: The present study was designed to determine the change of plasma kisspeptin levels during the menstrual cycle
Materials & Methods: A total of 20 women from friends and relatives pool were involved in this study. Selected from frinds and relative .They were selected after measuring their progesterone level on day 21 of menstrual cycle (excluding women who have anovulate menstrual cycle; low level of progesterone) , and then on 1 -5 day of the next menstrual cycle. All measurements were done in Teaching laboratories in Baghdad Teaching Hospital in Baghdad/Iraq. Five mls of blood withdrawn from each selected women by veinpuncture of selected women. ELISA technique was used for the measurement of serum kisspeptin - 1and progesterone level. Data were expressed as a mean ±SD. Results were evaluated using the student ttest for paired data. Conventional methods were used for the correlation and regression analyses.
Results: Results obtained showed that the levels of serum kisspeptin and progesterone were significantly higher on day 21of menstrual cycle than during menstruation period with p<0.01, also it was found a significant positive correlation of kisspeptin level with progesterone level (r= 0.77 ,p<0.01).
Conclusion: The results determine the role of kisspeptin on ovulation, and give a possibility for its beneficial manipulation of human fertility.
Urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1(PAI-1) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumors. This study revealed direct correlation between immunohistochemical expression of uPA with pathological stage. No significant association of immunohistochemical expressions of uPA, uPAR and PAI-1 with immunohistochemical expressions for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor -2 (HER-2/neu), and direct association between immunohistochemical expressions of (uPA and uPAR) as well as between immunohistochemical expr
... Show MoreThe current study was conducted in the period extending from November 2018 to October 2019 and designed as a case-control study and aimed to assess the seroprevalence of HCMV. However, a total number of 91serum specimens were collected to fulfill this purpose from females (71 breast cancer patients, and control group of 20 females) attending Al-Amal hospital for cancer management and Baghdad teaching hospital and the practical part was performed in College of Science, University of Baghdad. The study protocol was approved by the Ethics Committee at the Department of Biology (Reference: BEC/0220/0011). The immunological part for evaluation of seroprevalence of HCMV was accomplished by ELISA technique which revealed that anti-HCMV IgG was sco
... Show MoreBackground: The nasofrontal angle is the angle between the forehead & dorsum of the nose, it is of prime importance in giving the shape of the nose in relation to face. Workers studied this angle in living individuals, in this work, the angle was measured on dry human skulls, in addition, its value was statistically correlated with certain facial parameters.
Objectives: Determination of the value of nasofrontal angle in human skulls & correlation of this value to other facial parameters, namely; length of nasal bone, nasion height & midfacial length as these parameters are important for surgeons working in rhinoplasty.
Methods: The nasofrontal angle & other facial parameters were measured ca
Background: To elucidate the possible role of human cytomegalovirus in pregnancy loss through induction of certain pro-inflammatory adhesion molecules.
Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein and VCAM-1 molecule.
Results: Nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a
significantly higher expression of VCAM-1 in HCMV positive cases as compared with HCMV negative and the control groups (p = 0.05, 0.001 respectively).
Conclusion: HCMV infection may p
Human values are the most important concepts that the interest of society has to relay on these conceptual values. Any society will not be stabilized unless adheres to the right principles and values, all nations need such principles and values to stabilize. If any society doesn’t implement the human values that monotheistic religions urges equality between human, the far the society from the religious principles, the less there would be valence between human. The valence is urgent necessity in the current time. The far people get away from values and principles, the more they lose their freedom and dignity, therefore individual has to live with dignity and respect through the adherence to these values and principles. Apparently, equal
... Show MoreIn this current work, Purpose; to clearly the fundamental idea for constructing a design and
investigation of spur gear made of composite material its comes from the combination of (high
speeds, low noise, oil-les running, light weight, high strength, and more load capability)
encountered in modern engineering applications of the gear drives, when the usual metallic gear
cannot too overwhelming these combinations.
An analyzing of stresses and deformation under static and dynamic loading for spur gear tooth
by finite element method with isoparametric eight-nodded in total of 200 brick element with 340
nods in three degree of freedom per node was selected for this analysis. This is responsible for the
catastropic fa
Medicinal plants contain bioactive substances that are highly bioavailable in extracts or pure molecules, making them promising for therapeutic applications and precursors for chemo-pharmaceutical semi-synthesis. Harpagophytum procumbens (Devil’s Claw) is widely recognized as one of the most potent therapeutic herbs. This study aimed to extract seeds from H. procumbens using two types of solvents and to assess both qualitative and quantitative aspects of the extracts. The two extracts were evaluated for antibacterial and anti-biofilm activities using agar well diffusion assays against four bacterial isolates and two yeast isolates. Qualitative analysis identified the presence of alkaloids, flavonoids, tannins, saponins, and terpen
... Show MoreMedicinal plants contain bioactive substances that are highly bioavailable in extracts or pure molecules, making them promising for therapeutic applications and precursors for chemo-pharmaceutical semi-synthesis. Harpagophytum procumbens (Devil’s Claw) is widely recognized as one of the most potent therapeutic herbs. This study aimed to extract seeds from H. procumbens using two types of solvents and to assess both qualitative and quantitative aspects of the extracts. The two extracts were evaluated for antibacterial and anti-biofilm activities using agar well diffusion assays against four bacterial isolates and two yeast isolates. Qualitative analysis identified the presence of alkaloids, flavonoids, tannins, saponins, and terpen
... Show MoreIn this study; a three-dimensional model was created to simulate groundwater in Al-Haydariyah area of the governorate of Al-Najaf. A solid model was created to utilize the cross sections of 25 boreholes in the research region, and it was made out of two layers: sand and clay. The steady-state calibration was employed in six observation wells to calibrate the model and establish the hydraulic conductivity, which was 17.49 m/d for sand and 1.042 m/d for clay, with a recharge rate of 0.00007 m/day. The wells in the research region were reallocated with a distance of 1500 m between each well, resulting in 140 wells evenly distributed throughout the study area and with a discharge of 5 l/s, and the scenarios were run for 1000
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