Background: Bladder carcinoma is one of the most common cancer worldwide, it accounts for 6.5% of all cancers, with highest incidence in industrialized countries .It represents the fourth most common cancer in men and the eighth in women. Bladder carcinoma depends in its pathogenesis on a combination of genetic and environmental factors, these factors produce phenotypic changes that allow normal transitional cells to become cancerous and finally acquire the “malignant phenotype". Many attempts had been tried to explore the role of some genetic abnormalities encountered in bladder carcinoma. It has indicated that many genetic abnormalities may underline the pathogenesis of cancer evolution of urinary bladder like VEGF , P53, Bcl2 and RB, but nowadays a scientific efforts have raised the possible role of Her-2/neu in bladder carcinoma, and the rate of its overexpression in bladder carcinoma is ranging from 2% - 74%.
Objective: To estimate immunohistochemical expression of HER-2\neu receptor protein in Urinary Bladder Carcinoma in relation to other parameters; sex grade, pattern of tumor and stage of tumor .
Methods: The present work is performed in the Department of Pathology and Forensic medicine, College of Medicine, Kufa University. Formalin fixed, Paraffin-embedded blocks from 60 (43 males and 17 females) patients with urinary bladder carcinoma were included in this study. A group of 12 patients with chronic cystitis were included as a control group. Avidin-Biotin Complex method was employed for immunohistochemical detection of HER-2\neu.
Results: HER-2\neu overexpression was positive in 41.6% of urinary bladder carcinoma, while there was no expression in benign bladder tissue (P<0.05). HER-2\neu immunohistochemical staining was positively correlated with, grade and stage of urinary bladder carcinoma (P<0.05).
Conclusion: These findings support the role of HER-2\neu in the carcinogenesis of urinary bladder carcinoma regarding behavior, and aggressiveness, and thus HER-2\neu could be considered as a poor prognostic parameter in urinary bladder carcinoma.
Frictional resistance occurs whenever sliding happens, negatively impacting treatment outcomes and duration. It is a clinical challenge and must be dealt with efficiently to achieve the best orthodontic results. Aims of this study: compare and evaluate the static frictional forces under the wet condition to mimic the oral environment produced by using a polycrystalline ceramic bracket, monocrystalline ceramic bracket, 0.014 of an inch nickel-titanium (Rhodium coated archwires, and ilusio aesthetic archwires), and 0.019 x 0.025 of an inch stainless steel (Rhodium coated archwires, and ilusio aesthetic archwires). Ninety-six aesthetic brackets (48 monocrystalline and 48 polycrystalline brackets) were used and stored in different incub
... Show MoreBackground: The protective roles of vitamin C and total proteins in gingival inflammation were reported by several studies. The aim of this study was to measure the concentration of salivary vitamin C, total protein and their relation to gingival health among dental students. Materials and methods: The sample consisted of 67 dental students (33 males and 34 females) from College of Dentistry, University of Baghdad. Sillness and Löe (1964) was used for recording of dental plaque, while the gingival index (GI) was measured according to Löe and Sillness criteria (1963). Stimulated salivary samples were collected and chemically analyzed in Poisoning Center/Surgical Specialty Hospital by using colorimetric method to measure the salivary v
... Show MoreBackground: Diabetic neuropathy can affect any peripheral nerve, including sensory neurons, motor neurons, and the autonomic nervous system. Therefore, diabetic neuropathy has the potential to affect essentially any organ and can affect parts of the nervous system like the optic nerve, spinal cord, and brain. In addition, chronic hyperglycemia affects Schwann cells, and more severe patterns of diabetic neuropathy in humans involve demyelization. Schwann cell destruction might cause a number of changes in the axon. study aims to evaluate serum myelin protein level as a predicting marker in the diagnosis of diabetic neuropathy and to prevent early neuropathy complications of type 2 diabetes.
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... Show MoreBackground: Pregnancy is a physiological condition that affects the general and oral health.It is also associated with an increase in oxidative stress, which may presispose to oral diseases including dental caries. Aim of the study: This study aimed to measure salivary protein carbonyl, glutathione peroxidase and selenium levels of women who are pregnant and their association with dental caries in comparison to non-pregnant women, and to find out the mostly affected biomarker of oxidative stress during pregnancy. Subjects, materials and methods: A cross-sectional research was performed for a samples of 30 pregnant and 30 non-pregnant women who were chosen from city of Baghdad's Primary Healthcare Centers. Both groups aged 25-30 years. In
... Show MoreBackground: One of the major problems in endodontics is micro-leakage of root canal fillings which might contribute to the failure of endodontic treatment. To avoid this problem, a variety of sealers have been tested. The objective of this, in vitro, study was to evaluate the shear bond strength of four resin based sealers (AH plus, silver free AH26, RealSeal SE and Perma Evolution permanent root canal filling material) to dentin. Materials and Methods: Forty non-carious extracted lower premolars were used. The 2mm of the occlusal surfaces of teeth were sectioned, to expose the dentin surface. The exposed dentin surfaces of teeth were washed with 5ml of 2.5% NaOCl solution followed by 5ml of 17 % EDTA then rinsed by deionized water to remov
... Show MoreCongenital distal vaginal obstruction is usually asymptomatic in a newborn female. On rare occasions, it may present as an acute emergency with life threatening complications.This paper is reporting the rare condition of two newborn females presenting urgently with abdominal distension and acute urinary retention as a result of congenital distal vaginal Obstruction. The case history and urgent management shall be presented and both conditions shall be discussed.
BN RASHİD, 2023
Back ground: This is a prospective study of Head injury in Najaf.
Aim: to study the causes & out come & way of transferring the rat to the hospital & best way to investigate them.
Patients & methods:A prospective analytical study of 200 cases of Head injury patients, who were admitted to Saddam Teaching Hospital , in Najaf between 18 t" of November 1996 and 1st of September 1998.
Results: All age groups were included in this study, male to female ratio was 4:1 and the highest incidence was seen at the age group below 14 years. The two most common causes of
head injury were road traffic accident (RTA)(51 %) and assault (22%),of RTA pedestrians accounted for (87.25%). RTA accounted of (8
This research examines the future of television work in light of the challenges posed by artificial intelligence (AI). The study aims to explore the impact of AI on the form and content of television messages and identify areas where AI can be employed in television production. This study adopts a future-oriented exploratory approach, utilizing survey methodology. As the research focuses on foresight, the researcher gathers the opinions of AI experts and media specialists through in-depth interviews to obtain data and insights. The researcher selected 30 experts, with 15 experts in AI and 15 experts in media. The study reveals several findings, including the potential use of machine learning, deep learning, and na
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