Background: EEG recording showed a definite relationship between epileptiform EEG discharges and cognitive impairments (transient cognitive impairment “TCI”), since interictal spikes, which correspond to a large intracellular depolarization with evoked action potentials, in many ways mimic a “miniseizure.” Interictal spikes can result in transitory cognitive impairment with the type of deficit dependent on where in the cortex the spike arises. The interictal spikes, particularly if frequent and widespread, can impair cognitive abilities, through interference with waking learning and memory, and memory consolidation during sleep.
Objectives: the aim of this study is to evaluate the effect of subclinical epileptic discharges on cognitive function in patients with epilepsy.
Patients & Methods: This is a prospective study conducted in Basra teaching hospital in the period from December 2009 to February 2011 in order to evaluate the effect of epileptic discharge on cognitive function. EEG exam and cognitive function test (P300) was done for each patient four times at three months interval period, and one time for control group. Two hundred twenty four (224) patients included in this study with age range from (12-40) years. the EEG obtained after 30 mints of recording was categorized in to three groups frequent, infrequent and normal EEG record.
Results: we found that patients with frequent IEDs have high mean P300 latency when compared to patients with infrequent and normal EEG exam, also the mean p300 latency significantly reduced (more improvement in cognitive function) after treatment with AEDs.
Conclusion: Treatment of patients with frequent epileptic discharge improve cognitive function in patients with epilepsy, and reduction of IEDs greatly improve cognitive abilities in epileptics.
Background:Gastrointestinal cancers (GITc) is a worldwide problem. In Iraq , Gastric cancer is the 9th commonest of the top cancers while colorectal cancers it is considered as the 7th commonest ten cancers.IL-10 appears to be more of a pro-tumor than anti-tumor properties in both colorectal and gastric cancers.
Objective:is to estimate the serum level of IL-10 in the Iraqi colorectal and gastric cancer Patientsand its relation to the progress of disease.
Patients and Methods:In ourstudy ,54 serum samples werecollected starting from the 1st of January to mid of March 2011, to investigate the IL-10 serum level by using ELISA kit. 38colorectal and gastric cancer patients (H.Pylori +ve) and 16 of healthy control group.
Results: The
Background: Since the introduction of tumour necrosis factor-alpha (TNF-α) inhibitors including etanercept, their efficacy and safety in treatment of rheumatoid arthritis (RA) have been studied in many randomized controlled clinical trials. However, data regarding predictors of clinical response to anti-TNF therapy are still sparse.
Objective: To assess the predictors of response to etanercept in treatment of Iraqi patients with active RA.
Methods: An open label single group prospective study was conducted over 15 months on 190 Iraqi patients with RA. All the included patients were given etanercept at a dose of 50 mg by subcutaneous injection on
a weeklybases. Each patient was followed at regular intervals of bas
Around 65 million individuals suffer from epilepsy worldwide, and when it is not properly treated, it is linked to higher rates of physical harm and mortality. Due to the requirement for long‐term therapy and the side effects of many medications, medication compliance is a significant issue. The purpose of this review was to summarize the findings of previous studies examining the quality of life (QOL), adherence, patient education, and medication knowledge, as well as the impact of a pharmacist‐led educational intervention. Additionally, to find out if these studies benefit epileptic patients, to find the appropriate method used to help them in all aspects of their lives, and to use these in future studies. A systematic and comprehensi
... Show MoreOmentin (or intelectin) is a main visceral fat secretory adipokine. There is a growing interest to link omentin, obesity and co-morbidity factors. The aim of the present study is to evaluate serum omentin and its association to insulin resistance biomarkers, lipid profile and atherogenic indies. This cross – sectional study was conducted in Obesity Research and Therapy Unit-Alkindy College of Medicine by recruiting (115) individuals; 49 males /66 females. Subjects between (20 to 60) years of age were selected and classified into two groups according to their Body mass index (BMI). Group1 involved healthy lean volunteers (25 male/ 36 female; BMI 18.5 - 24.9). Group2 involved obese subjects; (24 male / 36 female with BMI ≥ 30). The s
... Show MoreEpilepsy is a critical neurological disorder with critical influences on the way of living of its victims and prominent features such as persistent convulsion periods followed by unconsciousness. Electroencephalogram (EEG) is one of the commonly used devices for seizure recognition and epilepsy detection. Recognition of convulsions using EEG waves takes a relatively long time because it is conducted physically by epileptologists. The EEG signals are analyzed and categorized, after being captured, into two types, which are normal or abnormal (indicating an epileptic seizure). This study relies on EEG signals which are provided by Arrhythmia Database. Thus, this work is a step beyond the traditional database mission of delivering use
... Show MoreBackground: Vitamin D and Leptin appears to play a range of roles in beta cell growth and insulin secretion and most importantly interaction with other hormonal mediators and regulators of energy and metabolism. Objective: The aim of this study was to measure serum leptin and vitamin D levels and to investigate their relationships with vitamin D and other clinical laboratory parameters in patients with type II diabetes. Subjects and Methods: Blood samples were taken from 80 patients with type II diabetes mellitus encountered during their attending the Internal Medicine clinic consultancy in Ramadi Teaching Hospital and the National Diabetes Center for Treatment and Research at Al-Mustansiriya University and 60 healthy subject. From Decem
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J Fac Med Baghdad 2014; Vol.56, No .2 Received Dec .2013 Accepted Mar. 2014 |
Background: Quality of life in brain tumor patients is an emerging issue and has prompted neurosurgeons to recon¬sider the need for cognitive assessment in the course of treatment. To date there has been a lack of comprehensive neuropsychological assessment performed preoperatively and in the acute postoperative period in our hospitals.Objectives: to establish the effects of tumors and their surgical treatment, from a neuropsychological perspective, on cognitive functioning in patients with cerebral Gliomas. Methods: This is a prospective study conducted in the Neurosurgical Hospital in Baghdad, Iraq, during the period from January 1999 to January 2001. Any patient admitted during the period of the study with clinical history, signs, sy
... Show MoreBackground: Giardia lamblia and Cryptosporidium parvum are recognized as important health problem in different countries. Humans may infect by two parasites at different age groups. But more common in countries with poor sanitation and unsafe water. Cellular and humoral response is engaged by the host to fight against parasitic infection, cytokines are produced by CD4 of payer's patches or generated from the mucosa lymphoid tissue as result of long duration antigen stimulation via trophozoites or cyst stage or others.
Objectives: To evaluate the levels of IL-2, -4 and C- reactive protein in the sera of patients with  
... Show MoreBackground: Patients with chronic renal failure ( CRF) are at increased rick of cardiovascular diseases and 60 of cardiovascular mortality in CRF is attributed to sudden death.