Preferred Language
Articles
/
iqjmc-67
Correlation between the histopathological grade and size of breast cancer with axillary lymph node involvement
...Show More Authors

Background: Breast cancer account for 29% of all newly diagnosed cancer in female and is responsible for 14% of cancer related deaths in women. Breast cancer is basically detected either during a screening tests, before symptoms have appeared, or after a woman notices a mass. Overall risk doubles each decade until the menopause, when the increase slows down or remains stable.
Objective: to find the correlation between the tumor size and grade and involvement of axillary lymph node.
Patients and methods: a continuous prospective study of 50 patients from 1st January 2016 to 1st January 2017 in Baghdad teaching hospital at 1st surgical floor, where almost all patients with breast cancer operated on by modified radical mastectomy and axillary clearance included in the study.
Results: the commonest age group was 5th decade with 32% of patients followed by 6th decade with 28% of patients. The most common histological type was IDC with 78% and 22% of patients were ILC. The most common stage at presentation was stage II A with 32% of patients followed by stage III A with 28% of patients. Tumor size between (2-5)cm (T2) was the most common with 68% of patients. Grade II was the commonest histological grade in this study with 68% of patients. Axillary lymph nodes (ALN) involvement increase as tumor size increase, it was 50% in T1, 55.8% in T2, 88.8% in T3 and 100% in T4. Grade I associate with 25% +ve ALN, grade II 55.8% and 100% in grade III.
Conclusion: The majority of patients in this study were in fifth and sixth decades. There is delay in presentation of patients as evidenced by the most common tumor size being T2 and the most common stage being stage II A& stage III A.IDC was the most common histological type. The most common grade was grade II. The larger the tumor the more incidence of ALN involvement, also the higher grade of the tumor associate with more ALN involvement.

خلفية البحث: سرطان الثدي يمثل ۲۹% من مجموع حالات السرطان المشخصة حديثا في الاناث وهو مسؤول عن۱٤% من الوفيات الناجمة عن السرطان في النساء. وعادة ما يتم الكشف عن سرطان الثدي أما اثناء الفحص, قبل ظهور الأعراض , او بعد ان تلاحظ المرأة وجود تورمز الخطر الكلي للأصابة يتضاعف كل عشر سنوات حتى سن اليأس , عندها تتباطأ الزيادة او تبقى مستقرة.

الهدف من الدراسة: للعثور على العلاقة بين حجم الورم والدرجة النسيجية وتورط العقد اللمفاوية الأبطية.

المرضى وطريقة العمل: دراسة استطلاعية متواصلة من1 كانون الثاني 2016 الى 1 كانون الثاني 2017 في مستشفى بغداد التعليمي , الطابق الجراحي الأول , حيث تم شمول تقريبا كل المرضى الذين يعانون من سرطان الثدي الذين أجري لهم أستئصال الثدي مع تنظيف الأبط .

النتائج: كانت الفئة العمرية الأكثر شيوعا هي العقد الخامس بنسبة 32% من المرضى تليها العقد السادس بنسبة 28% من المرضى. كان النوع النسيجي القنوي الأكثر شيوعا بنسبة 78% وكانت نسبة 22% من المرضى من النوع الغدي. وكانت المرحلة الأكثر شيوعا هي المرحلة 2 بنسبة 32% من المرضى تليها المرحلة 3 بنسبة 28% من المرضى. وكان حجم الورم بين (5-2)سم الأكثر شيوعا بنسبة 68% من المرضى. كانت الدرجة النسيجية 2 هي الأكثر شيوعا بنسبة 68%. تورط العقد اللمفاوية يزداد بأزدياد حجم الورم والدرجة النسيجية فهو 50% في T1 و 55.8% في T2 و 88.8% في T3 و 100% في T4. وكانت نسبة تورط العقد اللمفاوية 25% في الدرجة النسيجية 1 و 55.8% في الدرجة النسيجية 2 و 100% في الدرجة النسيجية 3.

الاستنتاج: الاغلبية في هذه الدراسة تتراوح اعمارهم بين العقد الخامس والسادس. هناك تاخير واضح للمرضى في الحضور لغرض الكشف عن المرض حيث ان اغلبية حجم المرض هو  تي 2   والمرحلة الشائعة للمرض هي الثانية اي  واغلبية الفحص النسيجي هي سرطان داخل القناة الخبيث واغلبية رتبة الورم النسيجية هي الرتبة الثانية وكلما زاد حجم الورم زادت معه قابلية اصابة الغدد اللمفاوية الابطية وكذلك كلما زادت رتبة الورم النسيجية زادت معه قابلية اضابة الغدد اللمفاوية الابطية بشكل اكبر.   

Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Mon Oct 14 2019
Journal Name
Open Access Macedonian Journal Of Medical Sciences
Comparison of Clinico-Pathological Presentations of Triple-Negative versus Triple-Positive and HER2 Iraqi Breast Cancer Patients
...Show More Authors

BACKGROUND: Breast cancer remains the most common malignancy among the Iraqi population. Affected patients exhibit different clinical behaviours according to the molecular subtypes of the tumour. AIM: To identify the clinical and pathological presentations of the Iraqi breast cancer subtypes identified by Estrogen receptors (ER), Progesterone receptors (PR) and HER2 expressions. PATIENTS AND METHODS: The present study comprised 486 Iraqi female patients diagnosed with breast cancer. ER, PR and HER2 contents of the primary tumours were assessed through immunohistochemical staining; classifying the patients into five different groups: Triple Negative (ER/PR negative/HER2 negative), Triple Positive (ER/PR positive/HER2 positive), Luminal A (ER

... Show More
View Publication Preview PDF
Scopus (1)
Crossref (2)
Scopus Crossref
Publication Date
Sun Dec 02 2018
Journal Name
Journal Of The College Of Education For Women
The Level of Career Involvement of Primary School Managers in Baghdad
...Show More Authors

The study aimed to identify career engagement among school principals, the researcher used descriptive approach and reached the study sample (230) school, principals. The researcher instruments used: career engagement, has been checked and face validity, and construction and consistency of the instruments using internal consistency Cronbach's alpha The study came to the following findings: - The degree of career engagement among school principals was (29.0200) this refers to a higher level, compared with the theoretical average of (27) and the study showed that the results showed no significant statistical differences between school principals in the level of career engagement due to the variable sex.

View Publication Preview PDF
Publication Date
Mon Oct 14 2019
Journal Name
Turkish Journal Of Biology
E2F6 is essential for cell viability in breast cancer cells during replication stress
...Show More Authors

Abstract: E2F6 is a member of the E2F family of transcription factors involved in regulation of a wide variety of genes through both activation and repression. E2F6 has been reported as overexpressed in breast cancers but whether or not this is important for tumor development is unclear. We first checked E2F6 expression in tumor cDNAs and the protein level in a range of breast cancer cell lines. RNA interference-mediated depletion was then used to assess the importance of E2F6 expression in cell lines with regard to cell cycle profile using fluorescence-activated cell sorting and a cell survival assay using (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). The overexpression of E2F6 was confirmed in breast tumor cDNA samp

... Show More
View Publication Preview PDF
Scopus (8)
Crossref (6)
Scopus Clarivate Crossref
Publication Date
Tue Jun 30 2015
Journal Name
Al-kindy College Medical Journal
Surgical –Audit on breast cancer risk factors in AL-Russafa district in Baghdad
...Show More Authors

Background: Breast cancer remains a substantial cause of morbidity and mortality, there is a need for continued efforts to understand the etiology of the disease, maintain screening effort, implement prevention strategies, and develop better treatments.Objective: To analyze the risk factors, improve early detection and prevention of breast cancer in Al-Russafa district- Baghdad, aiming to increase survival rate and improve the quality of life.Methods: A cross sectional audit of 258 breast cancer cases seen at Al-Elwiya maternity teaching hospital from January2009 to December 2011,data collected from patients files were: age, gender , residency, marital status, parity, age at menarche and menopause age at first live birth, hormonal therap

... Show More
View Publication Preview PDF
Publication Date
Thu Dec 01 2022
Journal Name
Baghdad Science Journal
Association of potent inflammatory Cytokine and Oxidative DNA Damage Biomarkers in Stomach cancer patients
...Show More Authors

The infection with H. Pylori stimulates a signaling cascade that causes the generation of Cytokines and provokes Oxidative stress that is involved in the chronic inflammatory response leads to Gastric cancers. Reactive oxygen species (ROS) produce 8-Hydroxydeoxyguanosine (8-OHdG), the persistent oxidative DNA damage product. The study objective was to assess if there was a link between inflammatory cytokine levels and the presence of Oxidative DNA damage in Gastric tumor patients. In addition, evaluation of the diagnostic and prognostic value of Oxidative DNA damage and inflammatory cytokine biomarkers for Stomach cancers is being conducted. The study was accomplished on medically diagnosed Stomach cancer patients before any form of trea

... Show More
View Publication Preview PDF
Scopus (6)
Scopus Clarivate Crossref
Publication Date
Sat Sep 14 2024
Journal Name
Al-rafidain Journal Of Medical Sciences ( Issn 2789-3219 )
Correlation between Serum Levels of Factor I, CD59, Interferon-gamma, and Interleukin-6 with the Response to Rituximab in Iraqi Patients with Rheumatoid Arthritis
...Show More Authors

Background: Rituximab is a chimeric IgG1 kappa immunoglobulin that has been genetically modified to incorporate human constant region sequences together with murine light- and heavy-chain variable region sequences. People use it to treat rheumatoid arthritis and certain malignancies. Objective: The study aimed to assess the potential association between the serum levels of Factor I, CD59, interleukins (IL)-6, and interferon-gamma (IFN)-γ and the response to Rituximab treatment in Iraqi rheumatoid arthritis patients. Methods: A cross-sectional study was conducted at the rheumatology center at Baghdad Teaching Hospital. Ninety adult patients who have been diagnosed with rheumatoid arthritis and are receiving  Rituximab intravenous i

... Show More
View Publication
Scopus Crossref
Publication Date
Fri Dec 08 2023
Journal Name
Iraqi Journal Of Science
Immunohistochemical Study of Estrogen, Progesterone Receptor and Her-2neu Oncogene with Her-2neu Biomarker Estimation by ELISA Technique in Primary Breast Cancer before Chemical Therapy
...Show More Authors

Breast cancer is one of the comments malignant tumors worldwide especially in Iraq; it is a leading cause of death in Iraqi women. Determination of estrogen and progesterone receptors status is helpful in selecting the patients most likely to receive benefit from endocrine therapy, and provide prognostic information on recurrence and survival since their expression is related to the degree of the tumor differentiation. From November 2012 to March 2013, 150 breast cancer patients at Al-Amal Hospital in Baghdad were attended to start treatment of disease for the first time. All patients included in this study did not receive chemotherapy. Patients were asked to bring their paraffin embedded tissue blocks to participate in estrogen, progest

... Show More
View Publication Preview PDF
Publication Date
Thu Jan 02 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Effect of doxorubicin on the histological structure of the kidneys in male albino rats
...Show More Authors

Background:  doxorubicin is one of the most active cytotoxic agents in current use, it has a very potent effect in the treatment of various malignancy either used alone or combined with other cytocidal agents, the antitumor activity of this drug associated with cytotoxic effect such as cardiotoxicity, hepatotoxicity,  nephrotoxicity, myelosuppression.

Objectives: - this study was designed to investigate the effect of the doxorubicin on the histological structure of the rats' kidney.


Results:
  -  Doxorubicin cause reduction in the body weight and changes in the histological structure of the kidney which are atrophy of some  glomeruli with

... Show More
View Publication Preview PDF
Crossref
Publication Date
Wed May 01 2019
Journal Name
Journal Of The College Of Education For Women
The Complex Relationship Between Darwinism, Geopolitics and Geographic Colonization Research the Relationship Between Geopolitics and Ethnography
...Show More Authors

Research on geopolitical and geopolitical studies relates to a range of sciences that can be called auxiliary sciences, such as political science, international relations in particular, and history, but their focus is rarely on science and ethnography

That the issues and problems of the world today has become so large and complex that does not allow a specific field or knowledge to solve one of the need for the newly known knowledge integration (geopolitics and geopolitics) in particular to move towards cognitive integration to understand many of the problems and global issues that faced The importance of this study comes to clarify the relationship between Darwinism, geopolitics and geopolitics. The geopolitics in modern terms d

... Show More
View Publication Preview PDF
Publication Date
Sun Oct 01 2017
Journal Name
Journal Of Economics And Administrative Sciences
Analysis of the relationship between modernity and economic development Analysis of the relationship between modernity and economic development
...Show More Authors

This research shows the problem of the economic development of underdeveloped countries in an unconventional way, as these papers explain the problems of the economic development. This research not only reviews the problems, but it illustrates them in a philosophical way, basis of the data of modernity, this mean it is a process of connecting between the absence of the modernity values and the failure of development in underdeveloped countries. The Search follows the descriptive approach to get to the goal of search by four main axes. The first axis includes clarifying  modernity and its principles, the second axis includes clarifying the economic development , the third axis includes the features of the mod

... Show More
View Publication Preview PDF
Crossref