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Correlation between the histopathological grade and size of breast cancer with axillary lymph node involvement
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Background: Breast cancer account for 29% of all newly diagnosed cancer in female and is responsible for 14% of cancer related deaths in women. Breast cancer is basically detected either during a screening tests, before symptoms have appeared, or after a woman notices a mass. Overall risk doubles each decade until the menopause, when the increase slows down or remains stable.
Objective: to find the correlation between the tumor size and grade and involvement of axillary lymph node.
Patients and methods: a continuous prospective study of 50 patients from 1st January 2016 to 1st January 2017 in Baghdad teaching hospital at 1st surgical floor, where almost all patients with breast cancer operated on by modified radical mastectomy and axillary clearance included in the study.
Results: the commonest age group was 5th decade with 32% of patients followed by 6th decade with 28% of patients. The most common histological type was IDC with 78% and 22% of patients were ILC. The most common stage at presentation was stage II A with 32% of patients followed by stage III A with 28% of patients. Tumor size between (2-5)cm (T2) was the most common with 68% of patients. Grade II was the commonest histological grade in this study with 68% of patients. Axillary lymph nodes (ALN) involvement increase as tumor size increase, it was 50% in T1, 55.8% in T2, 88.8% in T3 and 100% in T4. Grade I associate with 25% +ve ALN, grade II 55.8% and 100% in grade III.
Conclusion: The majority of patients in this study were in fifth and sixth decades. There is delay in presentation of patients as evidenced by the most common tumor size being T2 and the most common stage being stage II A& stage III A.IDC was the most common histological type. The most common grade was grade II. The larger the tumor the more incidence of ALN involvement, also the higher grade of the tumor associate with more ALN involvement.

خلفية البحث: سرطان الثدي يمثل ۲۹% من مجموع حالات السرطان المشخصة حديثا في الاناث وهو مسؤول عن۱٤% من الوفيات الناجمة عن السرطان في النساء. وعادة ما يتم الكشف عن سرطان الثدي أما اثناء الفحص, قبل ظهور الأعراض , او بعد ان تلاحظ المرأة وجود تورمز الخطر الكلي للأصابة يتضاعف كل عشر سنوات حتى سن اليأس , عندها تتباطأ الزيادة او تبقى مستقرة.

الهدف من الدراسة: للعثور على العلاقة بين حجم الورم والدرجة النسيجية وتورط العقد اللمفاوية الأبطية.

المرضى وطريقة العمل: دراسة استطلاعية متواصلة من1 كانون الثاني 2016 الى 1 كانون الثاني 2017 في مستشفى بغداد التعليمي , الطابق الجراحي الأول , حيث تم شمول تقريبا كل المرضى الذين يعانون من سرطان الثدي الذين أجري لهم أستئصال الثدي مع تنظيف الأبط .

النتائج: كانت الفئة العمرية الأكثر شيوعا هي العقد الخامس بنسبة 32% من المرضى تليها العقد السادس بنسبة 28% من المرضى. كان النوع النسيجي القنوي الأكثر شيوعا بنسبة 78% وكانت نسبة 22% من المرضى من النوع الغدي. وكانت المرحلة الأكثر شيوعا هي المرحلة 2 بنسبة 32% من المرضى تليها المرحلة 3 بنسبة 28% من المرضى. وكان حجم الورم بين (5-2)سم الأكثر شيوعا بنسبة 68% من المرضى. كانت الدرجة النسيجية 2 هي الأكثر شيوعا بنسبة 68%. تورط العقد اللمفاوية يزداد بأزدياد حجم الورم والدرجة النسيجية فهو 50% في T1 و 55.8% في T2 و 88.8% في T3 و 100% في T4. وكانت نسبة تورط العقد اللمفاوية 25% في الدرجة النسيجية 1 و 55.8% في الدرجة النسيجية 2 و 100% في الدرجة النسيجية 3.

الاستنتاج: الاغلبية في هذه الدراسة تتراوح اعمارهم بين العقد الخامس والسادس. هناك تاخير واضح للمرضى في الحضور لغرض الكشف عن المرض حيث ان اغلبية حجم المرض هو  تي 2   والمرحلة الشائعة للمرض هي الثانية اي  واغلبية الفحص النسيجي هي سرطان داخل القناة الخبيث واغلبية رتبة الورم النسيجية هي الرتبة الثانية وكلما زاد حجم الورم زادت معه قابلية اصابة الغدد اللمفاوية الابطية وكذلك كلما زادت رتبة الورم النسيجية زادت معه قابلية اضابة الغدد اللمفاوية الابطية بشكل اكبر.   

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Publication Date
Thu Feb 01 2024
Journal Name
Indonesian Journal Of Chemistry
Synthesis, Characterization, and Evaluation of MCF-7 (Breast Cancer) for Schiff, Mannich Bases, and Their Complexes
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A new synthesis of Schiff (K) 6 and Mannich bases (Q) 7 had formed compound (Q) 7 by reacting compound (K) with N-methylaniline at the presence of formalin 35% to given Mannich base (Q). Additionally, new complexes were formed by reacting Schiff base (K) with metal salts CuCl2·2H2O, PdCl2·2H2O, and PtCl6·6H2O by 2:1 of M:L ratio. New ligands and their complexes were characterized, exanimated, and confirmed through several techniques, including FTIR, UV-visible, 1H-NMR, 13C-NMR spectroscopy, CHN analysis, FAA, TG, molar conductivity, and magnetic susceptibility. These compounds and their complexes were screened against breast cancer cells. It was determined that several of these compounds had a significant anti-breast cancer effec

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Publication Date
Sun Jan 26 2020
Journal Name
Iraqi Journal Of Science
Correlation Between Serum Interleukinslevels with Anthropometric Data and Lipid Profiles in Obese Iraqi Women With Polycystic Ovary Syndrome
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This study was performed to assess the correlation of serum interleukins (ILs) levels with anthropometric data and lipid profile status in blood samples obtained from 100 Iraqi obese women with polycystic ovary syndrome PCOS. Obese non PCOS healthy women (n=75) matching in age (19-38 years) and body mass index(29.9-33.4kg/m2) served as a control group. The samples were collected from Kamal Al-Samurai Teaching hospital during the period of December 2017- June 2018.ELISA kits were used to measure serum levels of IL-6,IL-10,IL-18, IL-29,IL-33,tumor necrotic factor (TNF-α),high sensitive C-reactive protein (hsCRP),  insulin, total testosterone, and sex hormone binding globulin(SHBG).The biochemical measure

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Publication Date
Wed Mar 29 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
The Correlation between Rheumatoid Factor, Chloroquine Phosphate in Osteoarthritis
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Osteoarthritis (OA) is a series of aggressive destructive inflammatory processes. Synovitis is common both at an early and a late phase. This disease may be uniquely singular in some site but phylogenetically related at some point in time to produce a common outcome of dysfunction, disability, socioeconomic destruction and sometimes socioeconomic failure. Articular cartilage, subchondral bone and synovial membrane are the site of major abnormalities in this disease process. Rheumatoid factor (RF) represents one of the routine laboratory tests that made for all patients have joint complaints.Chloroquine phosphate (CQP) is agent belong to disease modifying osteoathritic drugs (DMOADs). Chloroquine and their derivatives have been used for t

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Publication Date
Fri Jan 26 2024
Journal Name
Iraqi Journal Of Science
An Evaluation of Some Risk Factors and ABO Blood Groups in Breast Cancer Patients
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The study involved 120 women, who were distributed into two groups of breast tumor patients (30 malignant and 30 benign) and a group of controls (60 women). The patients were referred to the Center for Early Detection of Breast Tumor at Al-Alwayia Hospital for Gynecology and Obstetrics (Baghdad) during the period June-December 2011. They were investigated for the frequency of ABO blood group phenotypes, menopausal status, oral contraceptive use, body mass index and family history of breast cancer or other cancers. The results demonstrated that 60.0% of malignant cases clustered after the age 50 years, while it was 20.0% in benign cases. Fifty percent of malignant breast tumor patients reached menopause, while in benign cases, the corresp

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Publication Date
Fri Mar 15 2024
Journal Name
Journal Of Baghdad College Of Dentistry
Assessment of the correlation between the tensile and diametrical compression strengths of 3D-printed denture base resin reinforced with ZrO2 nanoparticles
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Background: The mechanical properties of 3D-printed denture base resins are crucial factors for determining the quality and performance of dentures inside a patient’s mouth. Tensile strength and diametral compressive strength are two properties that could play significant roles in assessing the suitability of a material. Although they measure different aspects of material behavior, a conceptual link exists between them in terms of overall material strength and resilience. Aim: This study aims to investigate the correlation between tensile strength and diametral compressive strength after incorporating 2% ZrO2 nanoparticles (NPs) by weight into 3D-printed denture base resin. Methods: A total of 40 specimens (20 dumbbell-shaped and

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Publication Date
Sat Dec 30 2023
Journal Name
Iraqi Journal Of Science
Identification of Genomic Markers By RAPD-PCR Primers in Iraq Breast Cancer Patients
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Random Amplification of Polymorphic DNA (RAPD) analysis was used in this study to direct the attention toward increasing the efficiency of early diagnosis of breast cancer in clinical laboratories at Iraq using recent PCR-dependent protocols and investigate DNA polymorphisms in addition to the detection of genomic markers. Blood samples were collected from 12 diagnosed females with breast cancer (malignant) patients, 12 females with breast benign tumor and 12 controls (normal females). DNA was extracted and RAPD-PCR was performed. The results showed unique profiles of amplified DNA fragments produced in genomic DNA of breast tumors by an arbitrary primers of A8, A11, A12, A13, A15 and A18. Out of the 6 primers used, 1 primer produced mon

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Publication Date
Thu Jan 30 2020
Journal Name
Al-kindy College Medical Journal
Comparison between the Patterns of Common Breast Diseases Presenting as Breast Lumps in Pregnant and Non-Pregnant Married Women
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Background: Breast lump is one of the most common prevalent complaint of patients attending breast clinics.

Objective: To determine if there is any change in the pattern of common breast, diseases presenting as breast lumps between pregnant and non-pregnant women among patients attending Al-Elwiya Breast Clinic.

Methods: This is a cross – sectional study, with convent's patient sampling setting in AL-Elwiya Breast Cancer Early Detection Clinic from 1st Feb. to 1st May 2018, we collected data from patients with breast lumps including the age groups, pregnancy status, parity status, previous breast diseases, hormonal drugs, menstrual cycle, breast fe

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Publication Date
Tue Mar 03 2020
Journal Name
Molecular Biology Reports
Correlation of GSTP1 gene variants of male Iraqi waterpipe (Hookah) tobacco smokers and the risk of lung cancer
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Glutathione-S-transferases (GSTs) play a role in the detoxification of environmental chemicals and mutagens, such as those inhaled during tobacco smoking. There have been conflicting reports concerning GST polymorphisms as risk factors in the development of lung cancer. No studies focused on Arab populations exposed to Waterpipe (WP) tobacco smoke have been undertaken. Here Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and gene sequenc- ing were applied to analyze allelic variations in GSTP1-rs1695 and -rs1138272 amongst 123 lung cancer patients and 129 controls. The data suggest that WP smoking raised the risk of lung cancer more than three-fold (OR 3.6; 95% CI 2.1–6.0; p < 0.0001). However, there was no s

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Publication Date
Fri Apr 26 2019
Journal Name
Journal Of Contemporary Medical Sciences
Breast Cancer Decisive Parameters for Iraqi Women via Data Mining Techniques
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Objective This research investigates Breast Cancer real data for Iraqi women, these data are acquired manually from several Iraqi Hospitals of early detection for Breast Cancer. Data mining techniques are used to discover the hidden knowledge, unexpected patterns, and new rules from the dataset, which implies a large number of attributes. Methods Data mining techniques manipulate the redundant or simply irrelevant attributes to discover interesting patterns. However, the dataset is processed via Weka (The Waikato Environment for Knowledge Analysis) platform. The OneR technique is used as a machine learning classifier to evaluate the attribute worthy according to the class value. Results The evaluation is performed using

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Publication Date
Sun Dec 30 2018
Journal Name
Advances In Remote Sensing And Geo Informatics Applications
Correlation Between Surface Modeling and Pulse Width of FWF-Lidar
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