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The Relationship between Family History and C-peptide Level in Type2 Diabetic Patients

Background: Family history of type 2 diabetes is a major risk factor for type 2 diabetes. Type 2 diabetes is characterized by progressive β-cell dysfunction; many investigators have used C peptide levels as a biomarker of β-cell function.

Objective: the current study was design to investigate the impact of family history on biochemical characteristics (c-peptide, HbA1c, lipid profile, insulin secretion, insulin sensitivity and insulin resistance.

J Fac Med Baghdad

2013; Vol.55, No .3

Received Feb .2013

Accepted July.2013

Subjects and methods: three hundreds patients (152 males 148 females) with type 2 DM were enrolled in this study; and two hundreds individual serves as a control groups (103 male 97 female). The following clinical characteristics were reported: age, sex, waist circumference WC, systolic blood pressure SBP, diastolic blood pressure DBP, family history, body mass index BMI, laboratory analyses included serum c-peptide, blood glycosylated hemoglobin (HbA1c) assay, lipid profile which included serum cholesterol, serum triglyceride(TG), serum low density lipoprotein cholesterol (LDL) and serum high density lipoprotein-cholesterol (HDL). Insulin secretion, sensitivity and resistance were calculated from fasting serum glucose (FSG) (mg/dl) and C-peptide (ng/ml) values by homeostasis model assessment (HOMA).The statistical analysis was done by SPSS (statistical packagefor social sciences- version 17).

Result: Statistically was observed that highly significant increase in serum C-peptide in patients compared to control group (3.85±1.02 vs 1.53±0.24 p<0.01).The patients with a family history of type 2 diabetes mellitus had longer diabetes duration, heavier weight, higher levels of TG, LDL-cholesterol, and lowered age, HDL-cholesterol than those without a family history . Also, the presence of a family history of diabetes was associated with lower levels of fasting plasma C-peptide (3.01± 1.78 vs 4.95±1.82, p<0.05). Serum C-peptide had a significant negative correlation with family history and duration of diabetes. Furthermore, C-peptide was inversely correlated with HbA1c, and insulin sensitivity (HOMA-S). On the other hand, C-peptide correlated positively with BMI, DBP, LDL-cholesterol, TG, insulin resistance HOMA-IR, and insulin secretion HOMA-B. As well as, C-peptide did not show significant correlation with age, FSG, and TC. When the multiple linear analysis was executed with C-peptide as dependent variable with other independent variable (BMI, duration, family history, HOMA-IR, HOMA-S, and HOMA-B) there were significant result with this variables. The person correlation analyses to identify the parameters that most closely related with diabetic duration according to family history of diabetes; which showed that diabetic duration had a significant negative correlation with C-peptide, and HOMA-B only in patients with family history of Type2 DM (-0.126, and -0.229) respectively.

Conclusion: the current study suggested that subjects with a family history of diabetes mellitus are predisposed to develop this disease earlier. Although, serum C-peptide increased significantly in diabetics group compared with controls, and C-peptide decreased in patients with family history of diabetes. In addition, the results showed that family history of type2 diabetic patients is thought to have a deep impact on duration of the disease, lipid profile, insulin resistance, insulin sensitivity, and this may lead to higher prevalence of diabetic complication compared to patients without family history. These results support the necessity of earlier screening for diabetes in family members of T2DM patients and prevention the complications of the disease.

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Publication Date
Wed Oct 05 2016
Journal Name
Al-academy
Dialectical relationship between digital Technique and aesthetic Picture TV

The technical development has significant effects on the mediator Alcinmatugrave, and TV originated mainly based on technical, with the development and the continuation of these technologies and the enormous impact on the level of the television picture, initially dramas in recent times approaching in the aesthetic composition of the film thanks to the employment of modern digital technologies, Montag was not only one of the cinematic elements that went into television thanks to technical developments analogue and digital, and which added the possibility of large processors in the picture, high-definition digital cameras that have led to dispense often for artificial lighting intensive imaging light available, as these cameras have helpe

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Publication Date
Tue Nov 19 2024
Journal Name
Journal Of Baghdad College Of Dentistry
Correlation between crevicular C-reactive protein level with its serum level in chronic periodontitis patients

Background: The main purpose of this study is to find if there is any correlation between the level of C-reactive protein (CRP) in gingival crevicular fluid with its serum level in chronic periodontitis patients and to explore the differences between them according to the probing depth. Materials and methods: Forty seven male subjects enrolled in this study. Thirty males with chronic periodontitis considered as study group whom further subdivided according to probing depth into subgroup 1 with pocket depth ≤6mm, subgroup 2 with pocket depth >6mm. The other 17 subjects considered as controls. For all subjects, clinical examination where done for periodontal parameters plaque index (PLI), gingival index (GI), bleeding on probing (BOP),

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Publication Date
Thu Oct 01 2015
Journal Name
Journal Of Economics And Administrative Sciences
Analysis of the causal relationship between agricultural imports and some economic variables in Iraq

Foreign trade receives a good deal of economists' attention for its active contribution to economic growth, and imports of goods and services that could not be produced locally constitute an important share of the local economy.  Agricultural imports constitute an important share of the total imports due to their role in fulfilling the needs of local markets; however, the agricultural sector in Iraq contributes no more than a limited share of the country's need, which has encouraged the import of a variety of fruits, vegetables and strategic crops and different types of red and white meat. For the sake of identifying the factors affecting the demand on agricultural imports in Iraq, the following factors has been analyzed: th

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Publication Date
Wed Oct 01 2014
Journal Name
Journal Of Economics And Administrative Sciences
Measure and analyze the relationship between oil prices and the Iraqi dinar exchange rate

In this research, we discussed and analyzed the relationship between oil prices and the U.S. dollar exchange rate in Iraq. The study adopted the descriptive analysis and econometrics analysis. The descriptive analysis refers to the rise (fall) in crude oil price lead to appreciate (depreciate) in the Iraqi dinar exchange rate, though the channel of the international reserves. The econometrics analysis is based on monthly data covered the period (December/2002 – December/2011), the unit root test, co-integration test, vector error correction model, and Granger causality test have been adopted in this research to check the existence and direction of this relationship. The results refer to the lon

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Publication Date
Tue Jul 01 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The Relationship between Reproductive Hormones and Metabolic Parameters in Women with Polycystic Ovary Syndrome

Background: Polycystic ovarian syndrome (PCOS) is a condition associated with chronic anovulation, and androgen excess. Clinically, PCOS women usually presents with menstrual irregularities, infertility, and hirsutism. Women with this syndrome are at increased risk of metabolic syndrome (MS).
Patients and Methods:
This study was conducted during the period from March 2013 until the end of September 2013. A total of 50 PCOS women were studied   (25 PCOS women with MS and 25 PCOS women without MS) with an age ranged from (35-45) years. Women with PCOS were referred to Medical City Hospital in Baghdad and compared with 25 healthy women as control group. Serum luteinizing hormone (LH), follicle

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Publication Date
Sun Oct 02 2011
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The Relationship between Body Mass Index and Left Ventricular Structure and Function in Healthy Adults

Background: There is considerable evidence which associate cardiovascular morbidity and mortality with obesity, however, a direct effect of uncomplicated obesity on cardiac function is not well established.
Objective: To evaluate the relationship between body mass index (BMI) and left ventricular structure and function.
Methods: This cross-sectional study was carried out on (146) apparently healthy adults from both sexes (85 male and 61 female) aged 20-59 years(36.49±9.92 ). Subjects were grouped according to BMI into1.normal weight group included 47 subjects (BMI=18.5-24.9Kg/m2);2. Overweight group included 43 subjects (BMI=25-29.5 Kg/m2) and 3. obese group included (56) subjects(BMI≥30). Echo

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Publication Date
Mon Sep 01 2014
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
Analysis of the relationship between inflation and the tax revenue in Iraq for the period 1990-2010

The Iraqi economy has suffered for a long period of inflation because of the Iraq war and the resolutions and the sanctions that were imposed on Iraq, this phenomenon overshadowed at various aspects of the economy including the tax revenue that the State seeks to optimize the total income for the budget, the research covers the years 1990-2010, these years have been divided according to the country's economic variables.

The research  adopted on econometrics analysis that is based on the information and data available on topics and has been using statistical methods to test functions are formulated.

Research concluded that rates of inflation and GDP impact is limited to direct taxation and indirect in current prices a

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Publication Date
Mon Apr 24 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The Relationship between Interleukin-33(IL-33) and Oxidative Stress in Diabetic Patients with Cardiomyopathy

   Interleukin -33 (IL)-33 is among IL-1 cytokine superfamily , which shows promise as a biomarker predictive of mortality in diabetic and several cardiovascular disorders in vivo study.The objective of this study  is to investigate the differences in the levels of IL-33 between healthy controls and patients with type 2 diabetes and diabetic cardiomyopathy and to investigate the correlation of IL-33 with HbA1C (biomarkers of type 2 diabetes), hs-CRP  and oxidant –antioxidant status.    One hundred and fifty individuals (age 40-55) were enrolled in this study which was divided into three groups as follows: G1:50 healthy control,G2: 50 subjects with type 2 diabetes mellitus,G3: 50 patients with dia

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Publication Date
Tue Sep 08 2020
Journal Name
Baghdad Science Journal
Prevalence and Characterization of Some Colibactin Genes in Clinical Enterobacteriaceae isolates from Iraqi Patients

The members of the family of Eentrobacteriaceae harbour a gene cluster called polyketide synthase (pks) island. This cluster is responsible for the synthesis of the genotoxin colibactin that might have an important role in the induction of double-strand DNA breaks, leading to promote human colorectal cancer (CRC). Eleven out of the eighty eight isolates (12.5%) were pks+, distributed as 7 (8%) isolates of E. coli, 2 (2.25%) of K. pneumoniae and 2 (2.25%) of E. aerogenes. The cytotoxic effects of selected pks+ isolates (E. coli and E. aerogenes) on HeLa cells were represented by decreasing cell numbers and enlarged cell nuclei in comparison to the untreated cells. Cyt

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Publication Date
Sun Apr 01 2012
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Evaluation of signs of immune or metabolic disturbances among diabetic patients with positive islet cell antibodies

Background: Autoantibodies to islet cell antigens are known predictors of type 1 diabetes and detected in latent autoimmune diabetes in adults.
Objectives: This study aimed to identify the metabolic and immunological disturbances in diabetic patients with positive and negative islet cell antibodies (ICAs)
Materials and methods: A total number of 235 known cases of diabetes mellitus type 1 (160) and type 2 diabetes (75) were admitted in the study. Serum ICA and immunoglobulins (IgA, IgM, IgG) as well lipid profile were measured.
Results: Positive ICAs was found in 40 out of 120 T1D (33.3%) and 28 out of 75 T2D (37.3%). All the patients were poorly controlled diabetes with the evidence of significant high

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