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iqjmc-617
The Prevalence of Phenylketonuria and other metabolic diseases in sick Iraqi children; the importance of the newborn screening program.
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Background: Phenylketonuria (PKU) is one of the most important metabolic causes for mental retardation in children, in which early diagnosis would successfully prevent mental retardation, yet, there are some other serious metabolic diseases that share the same mode of presentation and some of the phenotypic manifestations also.
Methods:
During the period from August 2009 to August 2011, 63 cases were referred to the Children Welfare Teaching Hospital (CWTH) with clinical features  of PKU,  all were enrolled in this study, few blood drops on a special filter paper were taken from each patient and sent to a specialized metabolic laboratory in Saint Joseph University \Beirut, using tandem mass spectrophotometry (MS/MS). The results were received through internet after being analyzed and interpreted.Aim: This study aimed to assess the prevalence of PKU and other inborn errors of metabolism among sick children, presenting with clinical features suggestive of PKU, what are the diseases that share same clinical presentation of PKU, and make a proper early diagnosis and management when possible.

Results: out of the 63 cases, only 28(44.4%) came positive with different diseases, only 7(11.1%) were cases of PKU. The results also showed some other Inborn Errors of Metaboilsm(IEM): homocystinuria(HCY)or methionine adenosyltransferase(MAT) 7(11.1%),Methylmalonic academia (MMA)4(6.3%), maple serum urine disease (MSUD) in 3 cases(4.7%).The consanguinity was positive in 41 cases (65%). Positive family history was documented in 23(36.5%).All PKU cases had the background of consanguineous marriages (100%).

Conclusions: PKU is one of the most important metabolic cause for mental retardation in our study, but some other serious metabolic defects like homocystinuria(HCY) or MAT, organic acidemias, maple syrup urine  disease(MSUD) also causes mental retardation and share some of the phenotypic manifestations of PKU. Many families had positive history of affected siblings,especially those with consanguineous marriages.

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Publication Date
Thu Jul 18 2024
Journal Name
Herança
Heresy and Hypocrisy of the Church: A Marxist Analysis of Okezie Nwoka's God of Mercy
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Hypocrisy is found in various aspects of life, whether in religion, politics, or social parts. Hence, some of the church's hypocrisy is an outcome of different ups and downs in life. Starting with the problem in the novel, some of the hypocritical pastors engaged in an immense role in affecting the folk's lives because they persuaded people that God ordered them to do so. To accomplish their personal interests, the abusive monks disguise their verbal speech, smiles, and fine clothes like mild sheep to delusional followers, leaving them with guilt, shame, and spiritual scars. The present study aims to examine the hypocrisy and heresy of the church as portrayed in Okezie Nwoka's novel entitled God of Mercy. It reflects the source of

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Publication Date
Wed Jan 01 2020
Journal Name
Plant Archives J.
Evaluation of the performance of introduced varieties of maize under different planting dates and environments
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Publication Date
Fri May 01 2020
Journal Name
International Journal Of Psychosocial Rehabilitation
Building and codifying a scale of the level of tactical performance of advanced volleyball players
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The research objectives, to build a measure of the level of tactical performance of volleyball players applying for the Iraqi Premier League for the 2018-2019 season. The nature of the research problem, then the researchers determined the research sample in the deliberate manner of the players of the Iraqi clubs for the Premier League (B, A). The researchers adopted the entire community as a sample for the research, and the number (156) players distributed over (13) clubs and divided the sample into (12)players an exploratory experiment player representing (the police club) and (100) player representing the construction sample and after a maximum period of two months has passed since applying the scale to the construction sample the researc

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Publication Date
Mon Jan 01 2024
Journal Name
Baghdad Science Journal
Study of the Anticancer and Antimicrobial Biological Activity of a New Series of Thiohydantoin Derivatives
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        Recently, some prostate cancer patients have acquired resistance to the second -generation drugs (anzalutamide and apalutamide) prescribed for the treatment of this disease due to the emergence of the F876L mutation, which represents a challenge to modern medicine. In this study, a new series of 2-thiohydantoin derivatives were prepared through the reaction of different derivatives of maleimide (1c-4c) with isothiocyanate derivatives. The prepared compounds were diagnosed using FT-IR,1H-NMR ,13C-NMR, Mass spectra. The prepared series compounds has been studied against prostate cancer cells. The MTT assay was used to determine the activity of the prepared compounds against prostate cancer cells. The da

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Publication Date
Tue Feb 01 2022
Journal Name
Academy Of Accounting And Financial Studies Journal
EFFICIENCY OF PERFORMANCE AND COLLECTION OF INCOME TAX -REALISTIC VIEW OF THE GENERAL TAX AUTHORITY
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The process of evaluating and measuring tax performance is critical to support the tax collection process. The comparison of the amount of revenue collection with what is expected and the process of measuring tax performance continuously by the tax administration leads to increase the collection of tax, determine the size of deviations and stand and know the reasons and take the necessary measures to address them to get a better result in the future. According to the different tasks assigned to them, criteria and indicators for measuring the tax performance vary from one organization to another. These are indicators or criteria that measure tax revenue (i.e., amounts). One of the research's main findings was to raise the tax collection leve

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Publication Date
Sun Jun 02 2013
Journal Name
Baghdad Science Journal
Comparison of The Effect of Aqueous Extracts of two Plants, Origanum Vulgare L. and Fenugreek Seeds with Anticancer Drug Cis-Platin on the Growth of Cancer Cell Lines
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This study involved the effect of the aqueous extracts of two plants, Origanum vulgare L.(1), Trigonella Foenum Graecum L. (Fenugreek) seeds(2) on the growth of cancer cell lines. Rhabdomyo sarcomas (RD) of human cell line and female intestine cells of Albino mice (L20B) in vitro System. These extracts were compared with the known anticancer drug Cis-platinum(Cis-Pt) as a positive control. The phytochemical tests were used for screening the active compounds in plants. The inhibition activity assay was used as a parameter of the cytotoxic effect of these extracts. Cancer cell lines were treated with four concentrations of Cis-platin, 31.25, 62.5, 125 and 250 ?g/ml for 72 hour exposure time. The same concentrations were used for the other ext

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Publication Date
Wed May 16 2018
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Synthesis and Study the Mesomorphic Behaviour of New N- acetyl and Their Diazetine: Mono and Twin
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   Synthesis ,characterization of new mono and twin  compounds containing heterocyclic four member ring as, 1,3- diazetine by four steps. The first step; includes  preparation of 2- amino thiazole derivatives [I]a-c via ring closure reaction between acetophenone derivatives   with thiourea in I2,  while the second step includes condensation reaction between 2-amino thaizole derivatives[I]a-c and  p-methoxy benzaldehyde to produce Schiff bases[II]a-c. The third step includes neculophilic attach from imine group toacetyl chloride to give N- acetyl cross bonding[III]a-c.Finally ; the  fourth step is completed by the reaction of N- acetyl deri

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Publication Date
Sun Jan 04 2009
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Regeneration , Proliferation and Trans-differentiation of Adult Hepatic Oval Stem Cells into Functioning Beta-Cells and Exocrine Acinar Cells of the Pancreas in Diabetic Adult Rats
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Back ground: Although adult stem cells possess plasticity that permit differentiation along new lineages, production of exocrine and endocrine pancreatic cells and insulin-secreting beta-cells from adult non pancreatic stem cells has been considered controversial. We present that highly purified adult rat hepatic oval stem cells, which are capable of differentiation to hepatocytes and bile ducts epithelium, can also trans-differentiate into pancreatic exocrine-endocrine tissue, when homogenized hepatic tissue is implanted into subcutaneous tissue .
Methods and Materials: A total of 60 adult Swiss albino rats were divided into two groups . Group I , control group (30 animals) was injected with normal salin

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Publication Date
Sun Sep 29 2019
Journal Name
Iraqi Journal Of Science
Study the association between IL-17 level and autoimmune antibodies in hypo and hyper thyroidisms patients
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     The current study included measuring the level of IL-17A and IL-17F and some autoimmune antibodies related to the thyroid gland in case of  hypo and hyperthyroid in Iraqi patients to evaluate the correlation between all the measured parameters in this study.The study has been carried out in AL-Kindey Endocrine Gland and Diabetic Center in Baghdad during the period between February 2018 and May 2018, included:  88 patients were divided into three groups, The first group composed of 30 patients of Hypothyroidism that included (26) of them were females, (4) of them males. The second group composed of 30 of patients  of Hyperthyroidism  that included (20) of them were females, (10) of them were ma

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Publication Date
Tue Oct 01 2024
Journal Name
Results In Engineering
Nanomaterials in asphalt cement: exploring their single and combined effects on the physical and rheological properties
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