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Clinical features and therapeutic outcome of 30 patients diagnosed with primary myelofibrosis at the national center of hematology

Background: Primary myelofibrosis is characterized by clonal expansion of hematopoietic stem cell with a non-reactive clonal proliferation of fibroblasts and bone marrow fibrosis, which occurs at an extramedullary hematopoiesis. The clinical features of Primary myelofibrosis include anemia, marked splenomegaly and constitutional symptoms. Ineffective erythropoiesis and extra-medullary hematopoiesis are the main causes of anemia and organomegaly, respectively Objectives : the aim of this study was to evaluate the clinical features, diagnostic tools and the treatment outcome of patients with primary myelofibrosis.
Patients and methods: this is a prospective study conducted at the national center of hematology in Baghdad during the period between October 2009 and October 2013. It includes 30 adult patients diagnosed with primary myelofibrosis. Diagnosis was based primarily on bone marrow aspirate and biopsy. The patients were followed up and assessed monthly with complete blood picture and liver function test and renal function test with serum lactate dehydrogenase level.
Results: thirty patients were included in this study. There were 16 male and 14 female, the median age was 58 year with range (26-75) years. The most frequent presentation was in the group older than 60 years. Twenty four (80 %) patients had symptoms at diagnosis. The most frequent presentation were the fatigue, left upper quadrant swelling, night sweats, weight loss and fever. The main clinical features were huge splenomegaly which is found in 29 (97%) of patients, while the main finding in blood count at presentation were anemia followed by leukocytosis with leukoerythroblastic blood picture in 22 (73 %) of cases. The level of LDH was high in about 23 (77 %). The bone marrow biopsy showed fibrosis stage 2 in 24 (80 %).
Patients who died were in the highest risk groups. The median survival was approximately 28 months.
Conclusion: Primary myelofibrosis is part of myeloproliferative neoplasia; it usually runs chronic course. Till now none of the therapeutic modalities approved for treatment of primary myelofibrosis proved to be superior to others, yet the 5 year survival of this disease considered good.

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Publication Date
Wed Oct 01 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Serum Interleukine 35 in Iraqi female patients with newly diagnosed of rheumatoid arthritis.

Background: Rheumatoid arthritis (RA) characterized by local and systemic effects of inflammation has a wide range of biochemical markers implicated directly or indirectly to its pathogenesis.

Patients and method: Serum of (55 Females) of newly diagnosed RA and 23 healthy Females were used to estimate their interlukine levels.Objective: To evaluate interlukine 35 (IL-35) in Iraqi females with newly diagnosed
RA and to assess its contribution in the disease process.

Results: Females of RA showed a significant increase in the levels of interleukine 35(IL-35) and in the levels of High Sensitivity C-Reactive Protein (hs CRP). While there

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Publication Date
Tue Apr 01 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Immunohistochemical study of bone marrow angiogenesis using CD34 in adult acute lymphoblastic leukemia and its correlation with various pathological, laboratory and clinical parameters

Background: In recent years, bone marrow angiogenesis is indicated to be involved in the pathogenesis and progression of certain hematological malignancies like acute leukemia, lymphomas, and multiple myeloma. Recent studies have suggested that bone marrow angiogenesis plays an important role in the pathogenesis of adult acute lymphoblastic leukemia and also has prognostic value in the disease.
Objectives: at the present study, bone marrow angiogenesis in ALL will be examined using immunohistochemical staining for CD34, and this will be correlated with various pathological, laboratory and clinical parameters.
Patients and methods: A retrospective cross-sectional study was done on 60 patients with acute lymphoblastic leukemia (32 ma

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Publication Date
Wed Jan 02 2013
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Clinical study of patients with hypertrophic cardiomyopathy

Background: Hypertrophic cardiomyopathy (HCM) is a common genetic cardiovascular disease. Its morphologically divided into asymmetrical septal hypertrophy, symmetrical concentric hypertrophy and apical hypertrophy,and physiologically divided into obstructive HCM and non obstructive HCM according to the left ventricular outflow tract (LVOT) gradient at rest or with provocation. Several factors that increase risk of sudden cardiac death (SCD), the more risk factors a patient has, the greater the chance that the patient is exposed to sudden death and sufficient to warrant consideration for interventional therapy.

Objective: The aims of the study are to evaluate the clinical presentations, risk strat

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Publication Date
Sun Oct 02 2005
Journal Name
Journal Of The Faculty Of Medicine Baghdad
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Publication Date
Sat Jul 01 2017
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The Diagnostic Yield of Open Lung Biopsy in relation to clinical and radiological features in Patients with Suspected Interstitial Lung Disease

Background: The diagnosis of interstitial lung disease (ILD) is frequently delayed, because clinical clues are neglected and respiratory symptoms are ascribed to more common pulmonary diagnosis such as asthma and chronic obstructive pulmonary disease in the primary care setting.
Objective: To evaluate the diagnostic yield of open lung biopsy in patients with suspected ILD in relation to clinical and radiological features.
Patients and methods: Thirty-five patients were admitted with suspected interstitial lung disease (ILD), and scheduled for open lung biopsy (OLB) in Ghazi AL-Hariri hospital for surgical specialty, were included in this study. Data collected from the patient's files (who were subjected to open lung biopsies which

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Publication Date
Thu Jan 02 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Experience with treatment of fifty eight Iraqi patients with Acute Myeloid Leukemia

Background: Adults with Acute Myelogenous Leukemia (AML) have the lowest survival rate of all leukemias. Complete remission (CR) rate after induction therapy is about 55-85%, however 30% of patients fail to achieve remission and they remain alive only for about a year. Consolidation chemotherapy results in 5-year overall survival (OS) of about 30%.

Objectives: To study characteristics of adult patients with AML who attended Baghdad Teaching Hospital, their response to induction therapy and then to consolidation therapy, and their 5-year (OS) and disease free survival (DFS).

Results: Eleven patients who received attenuated induction therapy had a median survival of 6-8 mon

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Publication Date
Sun Jan 03 2016
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Coronary Artery Spasm; Frequency and Angiographic Findings in the Iraqi center for heart diseases (Single Centre experience)

Background: Coronary artery spasm occurs spontaneously leading to the syndrome of variant angina. It occurs in about 15 % of patients undergoing coronary angiography.
Objectives: This study sought to estimate the rate of coronary artery spasm that occurs during coronary angiography and percutaneous coronary intervention with their risk factors in patients admitted to the Iraqi center for heart disease.
Methods: This is a cross sectional observational study, We prospectively collected the data of patients over six months period (from August 2014 till February 2015 ) who developed coronary artery spasm during cardiac catheterization (diagnostic and therapeutic).
Results: Out of 1274 patients, 106 patients developed coronary artery

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Publication Date
Tue Dec 25 2018
Journal Name
Iraqi Journal Of Science
Demographic and Clinical Study on Patients Referred to The National Cancer Research Center for Pap Smears

A pap test is  a simple technique which  can detect pre-cancerous and cancerous cells in the vagina and cervix. Cervical cancer is the easiest gynecologic cancer we could  prevent it, with regular screening tests and follow-up this screening may avoid  cervical cancer  or detact  it early.This study aims to estimate cytological changes and precancerus lesions during Pap smear test and visual inspection of the cervix on Iraqi women and determine the relationship with demographic characteristics.   The study included 50 women aged 18-56 years (mean 39 ±10)   in  National Cancer of  Research Center (NCRC) belong to Baghdad University. These women suffered from genital problems or

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Publication Date
Mon Feb 15 2021
Journal Name
Iraqi National Journal Of Nursing Specialties
Effectiveness of Health Educational Program on Nurses' Practices toward Chemotherapy-Induced Peripheral Neuropathy for Children at Hematology Center in Baghdad City

Objectives: the study aims to assess nurses' practices toward chemotherapy-induced peripheral neuropathy (CIPN) for children at the hematology center, and to determine the effectiveness of the health education program on nurses' practices toward CIPN, and to find out the relationships between the effectiveness of Health education program and demographic characteristics of nurses.

Methodology: Use quasi-experimental design in the study (a design that divides the sample into two groups, a study group and a control group, with data collection in three stages). This study was conducted at a hematology center in Baghdad city for the period (from December 16th, 2019 to 8th May 202

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Publication Date
Tue Feb 26 2019
Journal Name
Journal Of Contemporary Medical Sciences
Demographic and clinical profiles of female patients diagnosed with breast cancer in Iraq

Objective To highlight the main demographic characteristics and clinical profiles of female patients registered with breast cancer in Iraq; focusing on the impact of age.Methods This retrospective study enrolled 1172 female patients who were diagnosed with breast cancer at the Main Center for Early Detection of Breast Cancer/Medical City Teaching Hospital in Baghdad. Data were extracted from an established information system, developed by the principal author under supervision of WHO, that was based on valid clinical records of Iraqi patients affected by breast cancer. The recorded information regarding clinical examination comprised positive palpable lumps, bloody nipple discharge, skin changes, bilateral breast involvement, tumor

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