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Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human colorectal Carcinoma (Clinicopathological study)
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Background: Colorectal adenocarcinoma is the most common type of gastrointestinal cancer, with about 150,000 cases each year in the United States and about 56,730 deaths from colorectal cancer risk. In Iraq and according to the Iraqi cancer registry (ICR) reports, the incidence of colorectal carcinoma was 4.55% of whole body malignancy, & it is the seventh cause of death from cancer (ICR 2005). In males, it’s the 7th common cancer while in females it’s the 4th most common cancer. The estrogen and progesterone receptors belong to a super- family of nuclear hormone receptors. These receptor proteins function as transcription factors when they are bound to their respective ligands, these receptors shares a common structural and functional organization

Objectives: to evaluate the immunohistochemical expression of estrogen (ER) and progesterone (PR) in colorectal adenocarcinoma and to correlate this expression with different clinical and pathological parameters.

Material and method: Twenty five cases of colorectal adenocarcinoma diagnosed in private laboratories in Baghdad/Iraq from November 2011 to march 2013, were respectively evaluated in term of age, gender, pathological diagnosis, including the tumor site, size, lymph nodes status, grade and stage of tumor. Using infiltrative ductal carcinoma of the breast as control for both estrogen and progesterone receptors expression were investigated immunohistochemically, nuclear and cytoplasmic staining of tumor cells were accepted positive.

Results: Fourteen (56%) of the cases were male, 11 (44%) case were female, with age distribution ranging from (24-84) years, with a mean age of 56.5 year. Tumor size ranges between 2.5-10 cm, mean of 6.25 cm. Seven cases (28%) cases were from the caecum, 5(20%) from each rectum, sigmoid and left colon respectively and 3(12%) cases were from more than one segment of the colon. Histologically the tumor grade ranges from moderately differentiated in 23(92%) cases and poorly differentiated in 2(8%) cases. Regarding pathological staging (TNM system), 5(20%) cases were stage T2, 17 (68%) cases were stage T3 and 3(12%) cases were T4, lymph node involvement found in 10(40%)  cases and distant metastasis were found in 2 (12%) cases. Estrogen receptors expression was positive in 2(8%) cases, while progesterone receptor was positive in 5(20%) cases; both ER positive cases were PR positive. Both ER positive cases were female; one of the PR positive cases was male. All of the ER and PR positive cases were moderately differentiated, one case of ER positive tumor showed nodal involvement while three cases of PR positive showed nodal involvement.      

Conclusion: - Estrogen and progesterone receptors in colorectal adenocarcinoma had same activity. The level of ER and PR expression in tumor tissue could not predict malignant biological behavior of the colorectal adenocarcinoma. No significant statistical correlation was observed between ER, PR expression and any of the studied clincopathological parameters.

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Publication Date
Tue Feb 28 2023
Journal Name
Iraqi Journal Of Science
Facies Architecture And Depositional Marine Systems of the Yamama Formation in Selected Wells, Southern Iraq
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      The Yamama Formation is characterized by a wide geographic extension of southern Iraq. Microfacies analysis of this formation was studied in six wells distributed in six fields: Fayhaa, Sindbad, Siba, Zubair, Ratawi and West Qurna. This research aims to determine paleoenvironments by diagnosing biofacies and lithofacies. Miscellaneous marine fauna of foraminifera and calcareous algae, mainly green algae (dasycladacean.) and skeletal bioclasts from gastropods, pelecypods, bryozoans, sponge spicules, and echinoderms were found. Petrographic studies and well logs interpretations led to the identification of five main Microfacies ( Mudstone, Wackestone, Packestone, Grainestone and Rudstone and twelve submicrofacies (Foraminiferal-

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Publication Date
Mon Sep 10 2018
Journal Name
Iraqi Journal Of Physics
The influence of magnetic field and cathode dimensions on plasma characteristics in hollow cathode system
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Experimental study on the effect of cylindrical hollow cathode, working pressure and magnetic field on spatial glow distribution and the characteristics of plasma produced by dc discharge in Argon gas, were investigated by image analyses for the plume within the plasma. It was found that the emission intensity appears as a periodic structure with many peaks appeared between the electrodes. Increasing the pressure leads to increase the number of intensity peaks finally converted to continuous form at high pressure, especially with applied of magnetic field, i.e. the plasma is more stable with the presence of magnetic field. The emission intensity study of plasma showed that the intensity has a maximum value at 1.07 mbar pressure and decre

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Publication Date
Wed Oct 07 2020
Journal Name
Indian Journal Of Forensic Medicine & Toxicology
Effect of Insecticide “Maxxthor” on Some Hematological and Oxidative Stress Parameters in Male Albino Rats
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The present study was designed to investigate the effect of different concentrations of Maxxthor on some hematological and oxidative stress parameters in male albino rats.Twenty male rats with age of 6-8 weeks and weight of 200-250gm were equally divided into four groups as follow:G1 treated with normal saline as control group,while G2,G3andG4groups were treated with(0.01,0.1,1)mg\kg body weight of Maxxthor respectively for 40 days.The following hematological parameters were measured: red blood cell(RBC),hemoglobin (Hb),white blood cell(WBC), platelets(PLT),malondialdehyde(MDA),glutathione(GSH),catalase and vitamin E. The hematological parameters results revealed highly significant(p<0.01)decreasein RBC and H,while a highly significant(p<0.

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Publication Date
Sat Feb 01 2020
Journal Name
Journal Of Southwest Jiaotong University
The Dynamics of an Eco-Epidemiological Model with Allee Effect and Harvesting in the Predator
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The aim of this study was to propose and evaluate an eco-epidemiological model with Allee effect and nonlinear harvesting in predators. It was assumed that there is an SI-type of disease in prey, and only portion of the prey would be attacked by the predator due to the fleeing of the remainder of the prey to a safe area. It was also assumed that the predator consumed the prey according to modified Holling type-II functional response. All possible equilibrium points were determined, and the local and global stabilities were investigated. The possibility of occurrence of local bifurcation was also studied. Numerical simulation was used to further evaluate the global dynamics and the effects of varying parameters on the asymptotic behavior of

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Publication Date
Fri Mar 15 2019
Journal Name
Journal Of Baghdad College Of Dentistry
Assessment of caries experience, enamel defects and selected salivary biomarkers in children with nutritional rickets
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Background: Nutritional Rickets is a condition produced by an absence of Vitamin D, calcium or phosphate. It clues to relaxing and fading of the bones. Dental expression of children with rickets contains enamel hypoplasia and delayed tooth eruption. This study was conducted in order to assess caries experience (dmfs) and enamel defects among study and control groups, and to evaluate and compare the levels of selected salivary biomarkers between children with nutritional rickets and apparently healthy children. Material and methods: Assessment of caries according to WHO in 1987, and assessment of enamel defects according to enamel defect index EDI of WHO in 1997. In addition a stimulated saliva samples were collected according to Palone e

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Publication Date
Sun Aug 13 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The Life Cycle and Larval Development of Neoechinorhynchus iraqensis (Acanthocephala: Neoechinorhynchidae) in the Intermediate Host
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For the first time, the life cycle of Neoechinorhynchus iraqensis, a parasite of Liza abu and other freshwater fishes in Iraq and its larval development in the intermediate host, the copepod Cyclops hyalinus was given. Hatching took place in the intestine of the copepod host within 10 minutes of exposure to the infective eggs. Motile acanthor penetrated the wall of the intestine within 2-4 hr. after exposure and was found free in the hemocoel where it metamorphoses through the acanthella stage. Acanthella stage revealed changes in the entoblast where the anterior section gave rise to brain, proboscis and proboscis receptacle. The posterior section differentiation gave rise to the genital system. By  12 days, development in the copep

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Publication Date
Fri Jan 20 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Determination of Visfatin Level in Patients with Diabetes and Peripheral Neuropathy as Early Predicted Factor
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Peripheral neuropathy represents one of the common diabetic complications in patients with diabetes mellitus type 2 (DMT2). Peripheral neuropathy affects the feet, legs, hands, and arms. It was found that one-third to one-half of diabetics have peripheral neuropathy. The current study aimed to evaluate the level of visfatin in diabetic patient groups with or without peripheral neuropathy in comparison with healthy subjects to knowledge whether visfatin can be applied as a predictor factor for this type of disease complication. The study included 120 males and females ranging in age from 40 to 97 years old. (40 patients with type 2 diabetes, 40 patients with diabetic peripheral neuropathy, and 40 healthy people served as the control group

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Publication Date
Sun Sep 05 2010
Journal Name
Baghdad Science Journal
The susceptibility test of vaginal yeasts and their relationship with the age in Iraqi women
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This study aims to isolate the pathogenic yeasts from genital tract and investigate their relationship with the age .The results clarified that the most pathogenic yeast isolated from genital tract was Candida albicans , also the results of C.albicanas isolates susceptibility test, to different antifungal revealed that they were sensitive to Miconazole, Ketoconazole and Clotrimazol and were resistant to Nystatin and Grisofulvin. The study of relationship of vaginal infection with the age showed that the incidence of infection with Candida was high among females age group (19-39 years).

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Publication Date
Sun Oct 03 2010
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Micronucleus formation assay and phagocytic index in mice administered water leaf extracts of Camellia sinensis
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Background: Green tea Camellia sinensis is non fermented tea. The tea is an infusion of flavorful leaves that has been consumed for centuries as a beverage and is valued for its medicinal properties. Over the last few decades green tea has been subjected to many scientific and medical studies to determine the extent of its long-purported health benefits, with some evidence suggesting regular green tea drinkers may have lower chances of heart disease and developing certain types of cancer. Green tea has also been claimed useful for weight loss management.
Methods: Three doses of the hot water extract were used (19.2, 38.4 and 57.6 mg/kg) to investigate micronucleus formation and phagocytic index. Mice were

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Publication Date
Sun Dec 30 2012
Journal Name
Al-kindy College Medical Journal
Assessment of High Sensitivity C.Reactive Protein in male patients with metabolic syndrome and atherosclerosis complications
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Background: syndrome X or metabolic syndrome is a collection of multiple diseases mainly visceral obesity , hypertriglyceridemia , decrease HDL level, hypertension and elevated fasting blood glucose that lead to accelerated atherosclerosis through multiple mechanisms, one of the most important is increase inflammation of the vessels manifested by elevated high sensitivity C reactive protein (hs-CRP).Objective: The aim of the study was to assess the prevalence of elevatedhs CRP in people with metabolic syndrome and atherosclerosis complication (IHD, Cerebrovascular disease, peripheral vascular disease) and metabolic syndrome without these complication.Patients and methods:;This is a cross sectional study carried out in Diabetic referral c

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