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Immunohistochemical evaluation of BCL-2 and KI-67 proteins in colorectal adenoma.
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Background: Development of colorectal adenocarcinoma principally occurs via the adenoma- carcinoma sequence of a multiple step process of tumor progression. This results from an accumulation of genetic changes in cells of intestinal mucosa. The use of molecular biomarkers may further aid in determining the risk of changing to carcinoma.

Objectives: To evaluate the expression of Bcl-2 and Ki-67 in colorectal adenomas and correlate the observed levels with age, gender, histological type, grades of dysplasia as well as to the levels of these two markers with each other.

Materials and Methods: A retrospective stu dy of fifty colorectal biopsies were selected randomly, 40 cases were with different grades of colorectal adenomas and 10 cases with normal mucosa as a control group; covering the period from 2010 till 2012. All the cases collected from the Gastroenterology and Hepatology Teaching Hospital. The biopsies were re-examined histologically and then stained immunohistochemically for Ki-67 and Bcl-2.

Results: There was a significant correlation only between Ki-67 expression and grade of adenoma and there was a significant correlation between Ki-67 and Bcl-2 expression in adenoma. Also there was a significant correlation between age of the patients and histologic type.

Conclusions: The assay of Ki-67 and Bcl-2 is valuable in detecting the risk of early colorectal carcinogenesis in patients with colorectal adenomas. Ki-67 expression increases with progression of the grade of adenoma while BCL-2 decrease with progression of the grade.

J Fac Med Baghdad

2014; Vol.56, No .2

Received Jan .2014

Accepted Mar. 2014

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Publication Date
Mon Apr 26 2021
Journal Name
Journal Of Real-time Image Processing
Fast and efficient recursive algorithm of Meixner polynomials
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Publication Date
Tue Feb 28 2023
Journal Name
International Journal Of Intelligent Engineering And Systems
Design and Implementation of EEG-Based Smart Structure
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Publication Date
Thu Sep 01 2016
Journal Name
Canadian Journal Of Physics
Thermo-elastic and optical properties of molybdenum nitride
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This contribution aims to investigate volume-dependent thermal and mechanical properties of the two most studied phases of molybdenum nitride (c-MoN and h-MoN) by means of the quasi-harmonic approximation approach (QHA) via first-principles calculations up to their melting point and a pressure of 12 GPa. Lattice constants, band gaps, and bulk modulus at 0 K match corresponding experimental measurements well. Calculated Bader’s charges indicate that Mo–N bonds exhibit a more ionic nature in the cubic MoN phase. Based on estimated Gibbs free energies, the cubic phase presents thermodynamic stability higher than that detected for hexagonl, with no phase transition observed in the selected T–P conditions as detected experimentall

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Publication Date
Wed Jun 12 2013
Journal Name
International Journal Of Computer Applications
Design and Implementation of a Practical FTTH Network
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Fiber-to-the-Home (FTTH) has long been recognized as a technology that provides future proof bandwidth [1], but has generally been too expensive to implement on a wide scale. However, reductions in the cost of electro-optic components and improvements in the handling of fiber optics now make FTTH a cost effective solution in many situations. The transition to FTTH in the access network is also a benefit for both consumers and service providers because it opens up the near limitless capacity of the core long-haul network to the local user. In this paper individual passive optical components, transceivers, and fibers has been put together to form a complete FTTH network. Then the implementation of the under construction Baghdad/Al

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Publication Date
Tue Jun 02 2020
Journal Name
International Journal Of Pharmaceutical Research
Synthesis, characterization and Study Bioactivity of Silver Nanocomposites
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The work include synthesis of nanocomposites (X / S / Ag) based on blend from Xanthan gum / sodium alginate polymers (X / S) with different loading of synthesized silver nanoparticales (0.01, 0.03 and 0.05 wt%) were added to the blend. The silver nanoparticles were prepared by reduction method and were characterized and analyzed using X-ray diffraction (XRD) and Atomic force microscope (AFM). XRD study showed the presence nanoparticle of silver with crystalline nature and face-centered cubic (FCC) structure and an average size of nanoparticles ranging from 32 to 37 nm. The surface study was performed using AFM which showed a fairly uniform shape to the nanocomposites and a spherical nature for the silver nanoparticles. The nanocomposite exh

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Publication Date
Thu Aug 31 2017
Journal Name
Journal Of Engineering
Advertising Technology and Visual Attraction of Cities Centers
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Advertising technology represents a component of elements of the visual attraction in the urban scape, made its way transmission process of messages between the ends of the source ofinformation (sender) and the Destination information (receiver) of the final recipient of themessage, It serves as a social marked and a means of cultural expression, It is part of the inalienable in creating identity and determine the spatial relationships and also is a reflection ofurban culture to the community. This technology has become an increasing feature of the present era, characterized as the era of the three revolutions: (the information revolution, the technologyrevolution, and the media revolution), Where it became an integral part of the visual

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Publication Date
Wed May 29 2019
Journal Name
Iraqi Journal Of Physics
A Spectroscopic and structural study of FeCoSb alloy
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Fe, Co and Sb nanopowders were fruitfully prepared by electrical wire explosion method in Double distilled and de-ionized water (DDDW) media. The formation of iron, cobalt and antimony (FeCoSb) alloy nanopowder was monitored by X-ray diffraction. The x-ray diffraction pattern indicates that there are iron, cobalt and antimony peaks. Optical properties of this alloy nanoparticles were characterized by UV-Visible absorption spectra. The absorption peak position is shifted to the lower wavelengths when the current increases. That means the mean size of the nanoparticles controlled by changing the magnitude of the current. The surface morphological analysis is carried out by employing Scanning Electron Microscope (SEM). Particles with varies

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Publication Date
Mon Dec 30 2002
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Modeling and Simulation of a Fire Tube Boiler
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Publication Date
Sun Jun 05 2016
Journal Name
Baghdad Science Journal
Synthesis and Characterization of Some New Morpholine Derivatives
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In this paper a new series of morpholine derivatives was prepared by reacting the morpholine with ethyl chloro acetate in the presence triethylamine as a catalyst in benzene gave morpholin-N-ethyl acetate(1) which reacted with hydrazine hydrate in ethanol, and gave morpholin-N-ethyl acetohydrazide (2) . Morpholin-N-aceto semithiocarbazide (3) were prepared by reacting compound(2) with ammonium thiocyanate , concentrated hydrochloric acid and ethanol as a solvent .Compound (3) reacted with sodium hydroxide and hydrochloric acid to give 5-(morpholin-N-methylene)-1H-1,2,4-triazole-3-thiol (4) .The new series of 1,2,4-triazol derivatives (5-8) was synthesized by reaction of compound(4) with formaldehyde , DMF as a solvent and different

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Publication Date
Mon May 21 2007
Journal Name
Journal Of Planner And Development
Architectural and Planning Features of Derna (Central Region)
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The city of Derna has distinctive architectural and architectural features, like other Arab and Islamic cities in the Arab West and North Africa. Its markets and shops have taken many different forms and structural forms within the urban fabric of the central commercial zone. The meeting between the various commercial and handicraft jobs and consumers within a spatial area starting with the old markets of the dark market and the agency of the harvest and vegetable market and the mosque of the old and the square of the mosque and the Red Square and the square Kharazin. It then grew linearly towards commercial hubs that were associated with the city's expansion axes. Old markets represent the architectural and planning heritage associated

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