Background: myocardial ischemia-reperfusion (I/R) injury may occur in a variety of clinical settings and this remains a significant problem. Oxygen free radicals, produced on reperfusion have been shown to play a major role in myocardial I/R injury. Various therapeutic effects have been described for Crataegus. Additionally, it has been presented that Crataegus has protective effect against ischemia reperfusion induced myocardial injuries to various organs. Therefore, it seems possible that the administration of Crataegus might protect the heart against the ischemia reperfusion injury.
Objectives: I detected the chemical components and trace elements of the aqueous extract of Crataegus leaves and determine whether Crataegus extract prevents or decreases ischemia-reperfusion induced myocardial injuries in rats.
Methods: The chemical composition of the aqueous extracts of the Crataegus leaves was analysed and concentration of some trace elements was estimated .Thirty-six rats were divided into three groups as control, I/R group and Crataegus treatment group. Blood samples were taken from the rats for the biochemical parameters estimating, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) oxidative stress levels of nitric oxide (NO) and lipid peroxidation (LPO).
Results: The results showed that the extract contain: glycosides saponins, tannins ,phenolic compounds , proteins and flavonoids . The results also showed that there were high concentrations of K , Na , Ca with (171.2 , 19 , 18.3) ppm, respectively and low concentrations of Fe, Zn ,Cu, Mg with (5.1, 3.2 ,2.3 ,1.9) ppm, respectively ,very low concentrations Cr ,Cd , Pb with (0.9 ,0.7, Nil) ppm . The levels of heart enzymes and Oxidative stress in group 3 were significantly lower than those in the group 2.Our results suggest that Crataegus treatment protects the rat heart against ischemia-reperfusion induced myocardial injuries.
Conclusion: The present study confirms that the aqueous extract of Crataegus contains (glycosides, tannins, proteins, saponins, phenolic compounds and flavonoids) as well as our results suggest that Crataegus treatment protects the rat heart against ischemia-reperfusion induced myocardial injuries .
Cataract is an opacity in the normally transparent focusing lens of the eye which leads to blindness. The aim of current study is to investigate the possible protective and therapeutic effects of aqueous extract of Foeniculum vulgare seed eye drops (0.5%) against selenite induced cataract in rabbits. Aqueous extract of Foeniculum vulgare seed prepared then formulated as eye drops. Sodium selenite used to induce cataract in rabbits' right eye by single intravitreal injection. Thirty-six rabbits included in the study and divided into three equal groups (12 rabbits in each group): healthy control group, Cataract-Induced group and group treated by Foeniculum vulgare seed extract eye drops. Parameters include the score of lens opacity which was
... Show MoreIn this study, the possible protective effects of daidzein on ifosfamide-induced neurotoxicity in male rats were examined by the determination of changes in selected oxidant–antioxidant markers of male rats’ brain tissue.
Twenty-eight (28) apparently-healthy Wistar male rats weighing (120-150gm) allocated into 4 groups (n=7) were used in this study. Rats orally-administered 1% tween 20 dissolved in distilled water/Control (Group I); rats were orally-administered daidzein suspension (100mg/kg) for 7 days (Group II); rats intraperitoneally-injected with a single dose of ifosfamide (500 mg/kg) (Group III); rats orally-administered for 7 days with the daidzein (100mg/
... Show MoreBackground: Iraqi people were exposed to mass disasters for long periods of time. Posttraumatic stress disorder (PTSD) may be of particular interest following a mass disaster. Evidence of poor school outcomes among adolescents affected by violence has been reported.
Objectives: To study the effect of PTSD on school achievement among secondary school children in Baghdad, Iraq.
Materials and methods: A total of 240 secondary school students from 4 secondary schools (2 for boys and 2 for girls) from Baghdad city were included. Multistage random sampling was carried out. Each student was interviewed and a questionnaire (consisted of demographic information, Harvard Trauma Questionnaire, and academic failure) was filled. Academic failur
Folic acid modulates several disorders in humans, pregnancy mostly because of the mitochondria-rich placenta, is a condition that favors oxidative stress.Transitional metals, especially iron, which are particularly abundant in the placenta, are important in the production of free radicals. Adenosine deaminase (ADA), an enzyme essential for the differentiation of lymphoid cells, has been used for monitoring diseases with altered immunity. In the present study we investigated the effect of regular and irregular administered folic acid in the first and second trimester of pregnancy to be compared with non-pregnant women ,and also the effect of regular and irregular using of folic acid supplement on oxidative stress parameters an
... Show MoreThis study was designed to investigate the protective effects of red cabbage and garlic extracts on the oxidative stress induced through treatment with fumonisin B1 in male mice. The study was conducted on sixty male mice that were divided randomly into six groups. Group 1included control mice, mice in group 2 received a daily oral dose (200 µg/kg.b.w) of fumonisin B1 for one month to induced mycotoxicosis, mice in group 3 received 500 mg/kg.b.w red cabbage extract plus fumonisin B1, mice in group 4 received only red cabbage extract, mice in group 5 received 500 mg/kg.b.w garlic extract plus fumonisin B1, and group 6 received garlic extract alone. After finishing the experiments, samples of blood were used for biochemi
... Show MoreBackground: the different roles of cytokines IL-4, IL-10, IL-12p40, IFN- during acute toxoplasmosis disease in pregnant women.
In this study, the aqueous extract of (Typha domingensis Pers.) pollen grain (qurraid) to know its ability to manufacture silver nanoparticles. Qurraid is a semi-solid yellow food substance, sold in Basra markets and eaten by the local population. It is made from the pollen of the T. domingensis Pers. plant after being pressed and treated with water vapor. The Gas chromatography–mass spectrometry (GC-MS) reaction was done to identify the active compounds of qurraid aqueous extract. The ability of the aqueous extract of qurraid to manufacture silver nanoparticles was tested, and the construction of silver nanoparticles was inferred by the reaction mixture's color, which ranged from yellow to dark brown. The synthesi
... Show MoreAbstract
The entities responsible for regulating the financial market are seeking to provide high quality accounting information, to provide appropriate protection to investors, and thus encourage them and attract them to increase their investments. the research reached several conclusion, the most prominent of which comes :-
1-The production of high quality accounting information reduces investment costs and costs of processing accounting information.
2- The production of high quality accounting information helps investors identify the best investment opportunities.
3- The results of the statistical analysis showed that there is significant
... Show MoreBackground: Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders leading to infertility. Majority of women with PCOS have insulin resistance and elevated hemoglobin A1c.The presence of thyroid dysfunction may affect the levels of HbA1c and the results of ovulation induction programs.  
... Show MoreCisplatin (CP), a platinum compound, is one of the most active cytotoxic drugs used for cancer treatment. Nephrotoxicity is severe dose limiting side effect of this drug. Abnormal production of reactive oxygen species (ROSs) leading to oxidative stress has been implicated in kidney toxicity by Cisplatin. Here the study was aimed to evaluate nephroprotective effect of ethanolic extract of Terminalia arjuna bark (EETAB) at the doses (200 & 400 mg/kg, body weight) against Cisplatin (7.5 mg/kg, i.p) induced nephrotoxicity in rats. The evaluation was done by measuring % change in body weight, renal function tests such as Blood Urea Nitrogen (BUN), Serum Creatinine (Cr), Serum Total Protein (TP) and also Kidney SOD (Super
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