Background: Chromogranin A is a useful tumor marker for neuroendocrine tumors (NETs) diagnosis & follow-up, Octreotide (somatostatin-long acting repeatable (SAS-LAR)) is an established treatment for NETs. Studies regarding the relation between response to SAS-LAR & the change in Chromogranin A (CgA) plasma level are still lacking.
Objectives: To determine the association between the using of Octreotide (SAS-LAR) and CgA level on time sequence & clinical status.
Patients & methods: a prospective observational study included 38 neuroendocrine patients in The Oncology Teaching Hospital/medical city complex/Baghdad, started at September 2013 till May 2016; assessing their circulating chromogranin A (CgA) plasma levels on multiple occasions(0,2 and 4 months) by ELISA technique and its correlation with response to somatostatin analogues (SAS-LAR) in those patients.
Results: the study recruited 38 neuroendocrine patients. 21 (55%) of them were males, 23 (60%) patients were older than 50 years old & 17 (44%) had metastasis to different sites. Somatostatin analogues (octreotide 30mg) was administered to 20 out of 38 (52.6%) studied patients. Serial CgA tests were performed in (17 out of 20) patients used SAS-LAR, with a change in mean value from (225.3 U/L) pre-using the agent to (17.5 U/L) two months after its use & to (8.7 U/L) four months after its use (p=0.009, p=0.002 respectively) while the change in mean of CgA level was from (205.9 U/L) to (200.9 U/L) in 10 patients who did not use Octreotide (p=0.2).Also results showed that no statistically significant difference in mean value of CgA pre & two months after using Octreotide with regard to grade of the tumor.
Conclusions: Plasma CgA is a reliable marker for NETs (regarding diagnosis, prognosis and response to treatment including somatostatin analogues).All patients with NETs should undergo a baseline plasma CgA level at diagnosis. Serial assessment of circulating CgA could be done for NET patients when there is baseline elevation of CgA level in circulation
Anew Solar concentrator have been designed in this paper, this concentrators Were based on the total internal reflection in a prism, the prism angles has been calculated by depending on the solar incident ray angle in baghdad for a year. The optical design consist ofa triangular presume, Where the solar cells on one side of the prism Wh?le the prism head towered the south. The results show that there is an increasing in the solar ray concentrators and the cell area is reduced.
Economic units can benefit from the cleaner production strategy, which aims to reduce the environmental impact of economic activities while improving efficiency and profitability. Accordingly, the aim of the research was to clarify the knowledge foundations of cleaner production costs and to indicate their role in reducing the costs of poor quality (the costs of failure). A set of conclusions has been reached, the most important of which is that cleaner production has achieved a reduction in the costs of external failure, represented by the costs of guarantee, by an amount of 12,339,000 dinars. Contributes to reducing the costs of failure, and based on the conclusions, a set of recommendations were presented, the most important of w
... Show MorePermanent deformation (Rutting) of asphalt pavements which appears in many roads in Iraq, have caused a major impact on pavement performance by reducing the useful service life of pavement and creating services hazards for highway users. The main objective of this research is investigating the effect of some contributory factors related to permanent deformation of asphalt concrete mixture. To meet the objectives of this research, available local materials are used including asphalt binder, aggregates, mineral filler and modified asphalt binder. The Superpave mix design system was adopted with varying volumetric compositions. The Superpave Gyratory Compactor was used to compact 24 asphalt concrete cylindrical specimens. To collect t
... Show MoreClimate change, together with terrorism, economic depressions, and mass-destructive weaponry, is a source of international phobia for many people. The advancement in technology increases the competition among world powers and economic systems to develop their industrial enterprises. The smoke that emits from the factories, the pollution caused by the industrial projects, the excessive use of green gas result in the increase of global warming and have catastrophic effects on the ecosphere of the planet. Besides, man’s wrong practices even in agricultural matters are exhausting the natural resources of the lands, and they badly affect the ecological diversity and the wellbeing of the humans and non-humans alike. Contemporary feminis
... Show MoreThe nature of interstellar matter has been explained by presenting a model consists of organic and inorganic materials mixture in the wavelength range (9-12) μm.
Laboratory samples of different concentrations of these materials were prepared and examined by using FTIR spectrometer device. Results of spectra for these samples are compared with observation of Trapezium nebula in the same wavelengths range. The best mixture model found to fit with observation is a sample consists of:11.96 % (Diatom silica (98% pure silica)) + 14.35 % (Carbon (C)) +27.63 % (Tryptophan amino acid) + 46.06 % (Tyrosine amino acid), this are done using convolution technique. Interstellar matter could be explained biologically, as the contribution of organic
Breast cancer is the second deadliest disease infected women worldwide. For this
reason the early detection is one of the most essential stop to overcomeit dependingon
automatic devices like artificial intelligent. Medical applications of machine learning
algorithmsare mostly based on their ability to handle classification problems,
including classifications of illnesses or to estimate prognosis. Before machine
learningis applied for diagnosis, it must be trained first. The research methodology
which isdetermines differentofmachine learning algorithms,such as Random tree,
ID3, CART, SMO, C4.5 and Naive Bayesto finds the best training algorithm result.
The contribution of this research is test the data set with mis
This study includes isolation , purification and identification of algae from different
aquatic environments in Baghdad.
Two different plant species belonging to different families were selected which were
Citrilluscolocynthus and Cordiamyxa for their fruits and fruits samples respectively.
Crude extracts were extracted from each plant and their antialgal activity were
evaluated.Different concentrations (5,15,25) mg/ml of these extracts were prepared
and their antagonistic activity was studied, and the resulted inhibition effects in ( %)
of concentration of chlorophyll(a) after 12 days was evaluated.
Results showed that Chloroccumhumicola was the most sensitive to these extracts.
However, Anabaena circinalis wa
One of the costliest problems facing the production of hydrocarbons in unconsolidated sandstone reservoirs is the production of sand once hydrocarbon production starts. The sanding start prediction model is very important to decide on sand control in the future, including whether or when sand control should be used. This research developed an easy-to-use Computer program to determine the beginning of sanding sites in the driven area. The model is based on estimating the critical pressure drop that occurs when sand is onset to produced. The outcomes have been drawn as a function of the free sand production with the critical flow rates for reservoir pressure decline. The results show that the pressure drawdown required to
... Show MoreThe Optical Fiber sensor based on the Surface Plasmon Resonance (SPR) technology has
been a successful performance sensing and presents high sensitivity. This thesis investigates the
performance of several structure of SPR sensor in field of refractive index and chemical
applications. A structure of Multi-Mode Fiber- Single Mode Fiber- Multi Mode Fiber (MMFSMF-MMF)