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Evaluation of the protective effect of Omega-7 against Methotrexate Genotoxicity in bone marrow Cells of Mice
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Background: A substance that can affect DNA or chromosomes is defined as a genotoxin. DNA damage in a somatic cell may result in a somatic mutation (cancer). In contrast, damage to a germ cell (germline mutation) may result in a heritable changed characteristic.Omega-7 is a non-essential monounsaturated free fatty acid with anti-inflammatory, anti-obesity, and antidiabetic effects.

Objectives: Evaluation of the possible protective effects of omega seven against methotrexate genotoxicity.

Method: Two major equal groups were obtained from seventy mice, and five subgroups (each of seven) were created from these groups as follows: Group I received liquid paraffin orally for seven successive days. Group II: received liquid paraffin orally for seven successive days, followed by a single intraperitoneal dose of methotrexate (20 mg/kg) on the eighth day. Group III: received omega-7 (50mg/kg) orally for seven successive days, followed by a single intraperitoneal dose of methotrexate (20 mg/kg) on the eighth day. Group IV: received omega-7 (100mg/kg) orally for seven successive days, followed by a single intraperitoneal dose of methotrexate (20 mg/kg) on the eighth day. Group V: received omega-7 (100mg/kg) orally for seven successive days. The first major group was intraperitoneally injected with 1mg/kg colchicine, and then after two hours, all mice were killed by spinal dislocation. Bone marrow cells from the first major group were used to measure the mitotic index and chromosomal aberrations, and bone marrow cell of the second group was used to measure the appearance of the micronucleus. Statistical Package for Social Sciences (SPSS) and ANOVA test were used to compare groups.

Results: Treatment of mice with omega-7 led to a significant decline in chromosomal aberration and micronucleus aberrance with a significant elevation of the mitotic index.

Conclusion: Omega-7 has been shown to have a protective role against methotrexate genotoxicity.

Received: April, 2023

Accepted: July, 2023

Published: Jan.2024

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Publication Date
Fri Mar 18 2022
Journal Name
International Journal Of Health Sciences
Histological and Immunohistochemical Study of the Protective Effect of Virgin Coconut Oil on Cyclophosphamide-induced Immunotoxicity of the Spleen and Peyer’s Patches
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Publication Date
Thu Aug 03 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The Effect of Bromocriptine Injection on Ovarieres and Uteri Through Early Pregnant Stages in Albino Mice
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This study was carried out on 10 adult females of albino mice ,  aged  8 – 10 weeks and      24 – 27 gm weight . In addition to 10 males were used for mating in order to determine the effect of injection of bromocriptine on the early stages of pregnancy and this was observed by measuring the weights of some component of female  reproduction  .                                                    The animals were divided into groups

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Publication Date
Wed Nov 24 2021
Journal Name
Iraqi Journal Of Science
Evaluation of Trichoderma Harzianum Biological Control Against Fusarium Oxysporum F. Sp. Melongenae
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The present study was conducted to biocontrol in vitro and in vivo of Fusarium
oxysporum that cause Fusarium wilt diseases for eggplant plants by using biological
control agent fungus Trichoderma harzianum. Fourteen isolates from F. oxysporum
were isolated and identified from two fields in Iraq. Pathogenicity test indicated that
all F. oxysporum isolates were pathogenic for eggplant but differed in its level of
pathogenicity. Four of the fourteen isolates from F. oxysporum were selected
depending on their highest pathogenicity for eggplant plants, F. oxysporum four
isolates F5, F6, F13 and F14 achieved at pre emergence 83.3%, 83.3%, 86.7% and
83.3% and at post emergence 90.0%, 90.0%, 83.3% and 76.7% respectively.

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Publication Date
Wed Jan 01 2020
Journal Name
Pakistan Journal Of Agricultural Sciences,
Evaluation of potent silver nanoparticles production from agaricus bisporus against helicobacter pylori
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Scopus (20)
Scopus
Publication Date
Tue Jan 30 2024
Journal Name
Iraqi Journal Of Science
The Effect of Doped TiO2 Layer on the Performance and Stability of PCDTBT: PCBM-based Organic Solar Cells
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     Charge extraction layers play a crucial role in developing the performance of the inverted organic solar cells. Using a transparent metal oxide with appropriate work function to the photoactive layer can significantly decrease interface recombination and enhance charge transport mechanism. Therefore, electron selective films that consist of aluminium-doped titanium dioxide (TiO2:Al) with different concentrations of Al (0.4, 0.8, and 1.2)wt %  were prepared using sol-gel technique. The inverted organic solar cells PCPDTBT: PCBM with Al doped TiO2 as electron extraction layer were fabricated. It is well known that Al doping concentration potentially affects the physical characteristics of the TiO2 by control

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Publication Date
Wed Jun 30 2010
Journal Name
Al-kindy College Medical Journal
Re-evaluation of lunation of the activity of somantibacterial drugs against clinical isolates of Escherichia coli in al- najaf al- ashref governorate
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ackground: Escherichia coli is one of the most
important bacterial pathogen that can cause several
disease to human being . In our study we try to
investigate the sensitivity resistance pattern of
Escherichia coli against three antibiotics ( Amikacin,
Nalidixic acid and Cephalexin).
Methods: For this purpose we collected 51 clinical
isolates of Escherichia coli from stool and urine of
outpatient and inpatient patients from different wards
of AL-SADER Teaching Hospital in AL-NAJAF
AL-ASHRAf, IRAQ, and tested by culture and
sensitivity test .
Results: The results appeared that Amikacin show
the highest percentage of sensitivity ( 66.66 % ) ,
while Cephalexin show the lowest percentage of
sensiti

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Publication Date
Fri Sep 01 2023
Journal Name
Energy Reports
Effect of solvents on performance of Alq3/ZnO solar cells: A theoretical approach
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Successfully, theoretical equations were established to study the effect of solvent polarities on the electron current density, fill factor and efficiencies of Tris (8-hydroxy) quinoline aluminum (Alq3)/ ZnO solar cells. Three different solvents studied in this theoretical works, namely 1-propanol, ethanol and acetonitrile. The quantum model of transition energy in donor–acceptor system was used to derive a current formula. After that, it has been used to calculate the fill factor and the efficiency of the solar cell. The calculations indicated that the efficiency of the solar cell is influenced by the polarity of solvents. The best performance was for the solar cell based on acetonitrile as a solvent with electron current density of (5.0

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Publication Date
Fri Sep 15 2023
Journal Name
Journal Of Baghdad University College Of Dentistry
Immunohistochemical evaluation for integrin binding sialoprotein on healing process of intrabony defect treated by bone sialoprotein
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Publication Date
Thu Sep 15 2022
Journal Name
Journal Of Baghdad College Of Dentistry
Immunohistochemical evaluation for integrin binding sialoprotein on healing process of intrabony defect treated by bone sialoprotein
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Background: Bone defect healing is a multidimensional procedure with an overlapping timeline that involves the regeneration of bone tissue. Due to bone's ability to regenerate, the vast majority of bone abnormalities can be restored intuitively under the right physiological conditions. The goal of this study is to examine the immunohistochemistry of bone sialoprotein in order to determine the effect of local application of bone sialoprotein on the healing of a rat tibia generated bone defect. Materials and Methods: In this experiment, 48 albino male rats weighing 300-400 grams and aged 6-8 months will be employed under controlled temperature, drinking, and food consumption settings. The animals will be subjected to a surgical procedure o

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Scopus Crossref
Publication Date
Sun Apr 03 2005
Journal Name
Journal Of The Faculty Of Medicine Baghdad
possible protective role of interleukin-4 in rheumatoid arthritis
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Background:

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