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A short-term comparison between the effect of two different concentrations of methotrexate on ovarian tissues and function of female albino rats: A short-term comparison between the effect of two different concentrations of methotrexate on ovarian tissues and function of female albino rats
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Back ground: methotrexate is an antifolate that is widely used in cancers and inflammatory or auto- immune diseases, it is also known to be contraindicated in pregnancy, breast feeding and not recommended in patients planning to be parents since it has a harmful effect on fetus and gonads.

    Ovarian function can be evaluated by certain parameters like the levels of female hormones or anti- Mullerian hormone which is considered as a good indicator for this purpose or histopathological examination of ovarian follicles especially the primordial follicles.

  Objective: the aim of this study is to determine the effect of two different concentrations of methotrexate on ovarian tissue integrity and function.

  Materials and method: adult female albino rats (n=30) were randomly divided in to 3 groups; group A (n=10) in which animals were treated with i. p injection of normal saline once weekly for four weeks, group B (n=10) in which animals were treated with i. p. injection of 1mg/ kg bw of methotrexate once weekly for four weeks, and lastly group C in which animals were treated with i. p. injection of 2.5 mg/ kg bw of methotrexate once weekly for four weeks. Then serum level of anti- Mullerian hormone were measured and histopathological examination of the ovaries were done to evaluate ovarian injury caused by methotrexate treatment.

    Results: this study has demonstrated that methotrexate in the both 1mg and 2.5 mg / kg of BW doses did not significantly reduce the levels of anti- Mullerian hormone and the number of primordial follicles and atretic follicles were also not significantly affected by the treatment of methotrexate in both doses. While histopathological examination revealed mild ovarian damage in case of treatment with 1mg/ kg bw of methotrexate and moderate damage in case of treatment with 2.5 mg/ kg bw of methotrexate.

     Conclusions: there is no important difference between the effects of 1 and 2.5 mg/ kg of BW of methotrexate on ovarian function but there is a slight difference in the effects of the two different doses on the integrity of ovarian tissue.

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Publication Date
Sun Feb 10 2019
Journal Name
Journal Of The College Of Education For Women
دور اﻟﺘﻐﺬﯾﺔ ﻓﻲ ﻣﺮﺣﻠﺔ اﻟﻄﻔﻮﻟﺔ اﻟﻤﺒﻜﺮة (3- 5 سنوات ( وبعض المتغيرات ودورها في اصابة الاطفال بتسوس الاسنان
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Teeth decay is one of the distinctive diseases which infects the children of generation .though it is not adeacly disease, it leads to huge problems , especially if it is infect children in their early childhood .There are many factors which lead to this disease , and to achieve the goal of this research in trying to stop the most important nutrition factors and others reasons that have relation with this disease .The practical application has been done for four months on children , who have been chosen randomly of the age ( 3-5 years) of both sexes , infected with teeth decay , from Baghdad city ( al karkh and al rusafa ) , the number of children reached to 90 child , divided into tow groups 45 male , and( 45 )female .Again they have be

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Publication Date
Wed Oct 04 2023
Journal Name
Arab Science Heritage Journal
المدراس الثانوية في الاعظمية ( ثانوية كلية بغداد- ثانوية الأعظمية للبنين – ثانوية الأعظمية للبنات - ثانوية الحريري للبنات) أنموذجاً
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Education received the attention of the monarchy in Iraq, especially after the developments that the country witnessed after Iraq gained independence and joined the League of Nations in 1932 AD in all political, economic and cultural aspects.  In this regard, due to its distinguished geographical location, where the atmosphere, the natural environment and the religious and political standing were available, which made it a center of attraction for most Iraqi families and political figures.  Learning and pioneering the path of knowledge, so it witnessed a great prosperity in secondary education, so several important schools appeared that contributed to advancing the wheel of learning forward, including Baghdad College High Schoo

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Publication Date
Tue Jan 01 2008
Journal Name
Journal Of Educational And Psychological Researches
أثر استخدام استراتيجيتي جانيه وميرل تينسون في اكتساب المفاهيم الجغرافية والاحتفاظ بها لدى طالبات الصف الرابع العام
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مشكلة البحث :-

     ظلت رغبة الانسان في المعرفة وفهم الكون الذي يعيش فيه ، ملازمة له منذ المراحل الاولى لتطور البشرية ، فالانسان بما يتمتع به من امكانات وقدرات وطاقات كامنة استطاع عن طريق تفاعله واحتكاكه الدائم والمستمر والخلاق مع البيئة المحيطة به ان يلاحظ ، ويتخيل ويتذكر ويفكر ويخطط ويبتكر ، مستفيداً من اخطائه في التعرف عليها ، وفي زيادة قدرته على التحكم فيها وتحسينها وتطويره

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Publication Date
Mon Nov 12 2018
Journal Name
Arab Science Heritage Journal
رسالة رسالة في طبقات القراء لتاج الدين أحمد عبد القادر بن مكتوم القيسي (ت 749هـ) دراسة وتحقيق
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 The writer of this messagewas Tajaddin Ahmad Abdulqader bin Maktoom Al-Qaisy Al-masry.

This message dealt with the biographies of twenty scientists of readers about Quran readings in Cairo . He comprehended these biographies and make it an appendage

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Publication Date
Mon Oct 15 2018
Journal Name
Arab Science Heritage Journal
رؤساء رؤساء النصارى في كتاب أخبار بطاركة كرسي المشرق (132- 542هـ/ 749- 1147م) دراسة تاريخية (القسم الثاني)
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The research deals with the Presidents of the Christians who called themselves (Ghaltka) in the book titled (orient chirsy patriarchs) that talked about their scientific practical biography adding to) that their completeness on the position of Ghaltka with its decrees and caliphs who were contemporaries to them ,as well as their places, deaths, cemeteries and their accomplishments In accordance with the powers granted to them and also it mentions the situation of The Abbasid caliphate with them and with the sons of their sect .

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Publication Date
Sat Mar 01 2008
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
اعتماد منهج ال Six Sigma كالية لتحسين جودة اداء السلطة الضريبية: دراسة حالة في الهيئة العامة للضرائب
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This research aims to improve the process Tax accounting by using the scientific method to such as Six Sigma DMAIC steps called in General. Authority for Tax accounting . this approach has been described Tax accounting process Fully and identify problems experienced by the measurement and analysis and identify the critical success factors to satisfy customers and adoption process redesign Tax accounting process with the possibility of obtaining a high-quality revenue to be used by the body to improve its performance . Collected data and information from interviews with officials, staff and see the details & the conduct & operations in the body, and used well as a questionnair to measure the quality & services present action b

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Publication Date
Thu Nov 09 2023
Journal Name
Journal Of Intelligence Research
الوعي بالتدوير الكيميائي وعلاقته بالتفكير العلمي لدى طلبة قسم الكيمياء في كلية التربية للعلوم الصرفة ابن الهيثم
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يهدف البحث التعرف على مستوى الوعي بتقنيات إعادة التدوير غير الميكانيكية التي يجري تطويرها حاليًا في قطاع "إعادة التدوير الكيميائي" الجديد لدى طلبة كلية التربية للعلوم الصرفة -ابن الهيثم. تكونت عينة البحث من (198) طالبا وطالبة من قسم الكيمياء للعام الدراسي (2021-2022) من أصل(250) أي (79%) من مجتمع البحث لدراسة الفصول الصباحية و(50) طالباً وطالبة من أصل (73) أي (68٪) من مجتمع البحث لدراسة الفصول المسائية لطلبة المرحلة الرابعة.وت

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Publication Date
Sat Jan 11 2025
Journal Name
Iraqi Journal For Administrative Sciences
قياس الكفاءة التقنية لوحدات اتخاذ القرار باسلوب التحليل التطويقي للبيانات ( DEA) بحث ميداني في الشركة العامة للنقل البري
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this research aims it measure the technical efficiency of the branches of the General Company for Land Transport, That scattered geographically at country level, by Data Envelopment analysis (DEA) technique, as this technique relies on measuring the efficiency of a set of asymmetric Decision making units, which is one of the nonparametric mathematical methods for and application related to Linear Programming, and this is what helps the General Company for Land Transport to diagnose its branches performance by benchmarking with each other and determine the performance gap. The research found that there is variation in the level of efficiency in the company's branches

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Publication Date
Wed Apr 01 2015
Journal Name
Journal Of Educational And Psychological Researches
اثر طريقة الملاحظات الصفية باستخدام الحاسوب( كمنشطات عقلية) في التحصيل الدراسي لمادة الفيزياء لدى طالبات الصف الأول المتوسط
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The research aim to know the effect of note–taking by computer method as amentalactivators in achievement of physics subject for the first intermediate class students.

To investigate from aim of the research the research sample was chosen from the first intermediate class students in Al–mutamyzat secondary school for girls. Which belongs to the general administration for the second karkh education which randomly chosen from (9) schools for distinct female students in Baghdad. Then randomly chosen two sections form three about (80) female students at (66.667%) from total sample it’s about (120) female student in the three sections. The randomly chosen too, section (a) to represent experimental group it’s about (41) female

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Publication Date
Sun Jan 03 2010
Journal Name
Journal Of Educational And Psychological Researches
سياسة اعداد معلم المرحلة الابتدائية في العراق ماقبل احداث 9/4/2003 نظرة نقدية , ووضع انموذجا مقترح معاصرلها
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شغلت  قضية اعداد المعلم  اهتمامات العديد من المسؤولين في قطاع التربيه والتعليم وكذلك اولياء امور الطلبه واساتذه الجامعه , ولازالت الهم الاكبر , وذلك لاختلاف سياسه اعداد المعلم من دولة واخرى وحسب الفلسفه التربويه  والمتغيرات والتطورات السريعه التي يشهدها العالم

            وفي ضوء ماتقدم , ان المعلم هو احد عناصر العمليه التربويه في اي بلد . بعد الطالب والمنه

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