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the Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma
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Abstract   

 

Background

Stathmin1 (also known as metablastin) is a major microtubule-depolymerizing protein that involved in cell cycle progression and cell motility.

 Stathmin1 has been found to be up-regulated in some cancers and correlated with cell differentiation and proliferation.  

Stathmin1 is a major cytosolic phosphoprotein that regulates microtubule dynamics and is associated with malignant phenotypes in various cancers, including non-small cell lung cancer.

 

Objective

 To evaluate the role of Immunohistochemical expression of stathmin1 in non-small lung carcinoma and its correlation to different prognostic factors or parameters.

 

Materials and methods

This retrospective study carried on formalin fixed paraffin embedded surgical specimens of lung tumors  Applying the Immunohistochemical techniques by using the primary antibodies to stathmin1, statistical analysis done and assessment of correlation with different clinical and pathological parameters measured.

 

 Results

Fifty cases of Non-small lung carcinomas that 42% adenocarcinoma,44% squamous cell carcinoma 10% adenosequamous and 4% non-small lung carcinoma 84 % were Stathmin-1 positive.

 No significant correlation between Stathmin-1 expression with age and gender of patients but Stathmin-1 expression were correlated with parameters including type and grade of tumor.

High expression was noted in poorly differentiated tumors.

 

Conclusions

Measurement of stathmin1 level may be a beneficial prognostic biomarker for non-small lung tumors especially those of poorly differentiated tumors

Stathmin1 expression in non-small cell lung carcinoma significantly correlated with poor tumor differentiation and could be considered as independent prognostic factor.

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Publication Date
Tue Mar 15 2022
Journal Name
Journal Of Baghdad College Of Dentistry
In vitro cytotoxic effect of annona squamosa pulp ex-tract as a mouthwash for children on human normal cell line
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Background: Fruits and their by-products are the primary sources of bioactive chemicals in plants. Because of its phytochemical richness, Annona squamosa fruits have gained the alertness of people willing in health-promoting diets. The purpose of this in vitro study was to evaluate the cytocompatibility effect of ethanolic crude extract of Annona squamosa pulp against a human normal cell line as a mouthwash for children. Material and method: The ethanolic extract of Annona squamosa pulp was extracted using the ultrasonic method and then lyophilized to make it powder. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) test was performed to investigate the cytotoxic activity of the pulp extract on a human normal cell l

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Publication Date
Fri Feb 01 2019
Journal Name
Journal Of Economics And Administrative Sciences
The impact of organizational learning capabilities on the promotion of knowledge capital Applied research at Wasit University
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Abstract

      The current research aims at identifying any of the dimensions of organizational learning abilities that are more influential in the knowledge capital of the university and the extent to which they can be applied effectively at Wasit University. The current research dealt with organizational learning abilities as an explanatory variable in four dimensions (Experimentation and openness, sharing and transfer of knowledge, dialogue, interaction with the external environment ), and knowledge capital as a transient variable, with four dimensions (human capital, structural capital, client capital, operational capital). The problem of research is the following questio

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Publication Date
Thu Jan 06 2022
Journal Name
Iraqi National Journal Of Nursing Specialties
Effectiveness of an Instructional Program on Patientsꞌ Knowledge about Home Safety While Receiving Anti -Cancer Medications at Al- Karama Teaching Hospital in Al-Kut City
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Objectives: To determine the effectiveness of the instructional program on patients’ knowledge about home safety while receiving anti-cancer treatment at  Al- Karama Teaching Hospital in Al-Kut City.

Methodology:   A quasi-experimental design is conducted through the application of a pre-test and post-test approach for the study and control groups from February 5th, 2020 to April 25th, 2020. A non–probability (purposive) sample of (50) patients treated at the Blood Disease and Oncology Center is selected and divided into two groups. Each group contains (25) patients as control and study groups. An instrument is constructed that is comprised of two parts; t

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Publication Date
Wed Dec 12 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Effectiveness of Instructional Health Educational Vascular Access on Hemodialysis Patients' Knowledge at Al-Hussein Teaching Hospital in AL-Nasiriyah City.
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Objectives: The study aims: (1) To determine effectiveness of instructional health education vascular access on hemodialysis patients' knowledge, (2) To find out the association between effects of instructional health education vascular access and demographic characteristics of (age, gender and educational level). Methodology: A quasi experimental study –control study design is carried out at AL-Hussein Teaching Hospital in AL-Nasiriyah City, from 3November,2015 to 2 June, 2016. A non-probability (Purposive sample) of (80) patients with vascular access devices on maintenance hemodialysis patients divided int

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Publication Date
Mon Dec 01 2014
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
The impact of exercising occupational hypocrisy on organizational strategic success: An Empirical study on university of kufa faculty of administration and economic
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This research aims to identify the relationship between occupational hypocrisy and organizational strategic success, It was done by analyzing the correlations and influence between variables,  applied to a random sample of university professors at the University of Kufa faculty of administration and economic.

 The main tool for data collection is the survey were questionnaires were distributed randomly to the professors , and (43) questionnaires were returned, and test its validity by using (SEM) (Structural Equation Modeling), Hypothesis has been tested by using Statistical Package for Social Sciences (SPSS v. 18), The research found a set of conclusions:(The occupational hypocrisy has

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Publication Date
Sun Oct 01 2006
Journal Name
Journal Of Educational And Psychological Researches
قياس المسؤولية الاجتماعية لدى طلبة جامعة القادسية
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أهمية البحث والحاجة إليه:

تبدو لنا المسؤولية الاجتماعية بأنها أحدى الخصائص التي يكتسبها الفرد من بيئته الاجتماعية, بتأثير مجموعة القيم التي تحكم سلوك الأفراد في ذلك المجتمع فتبدأ المسؤولية الاجتماعية بأولى صورها على شكل إدراك الفرد لمتطلبات المجتمع وإدراكه لدوره في المساهمة في أنجاز تلك المتطلبات, وفي الواقع إن الإدراك لوحده لا يكفي لان يمارس الفرد مسؤوليته داخل المجتمع, فيظهر المستوى الأخر و

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Publication Date
Sun Apr 01 2012
Journal Name
Journal Of Educational And Psychological Researches
Perceived Self-efficacy for university students
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Research was: 1- known as self-efficacy when students perceived the university. 2- know the significance of statistical differences in perceived self-efficacy according to gender and specialty. Formed the research sample of (300) students were chosen from the original research community by way of random (150) male specialization and scientific and humanitarian (150) females specialized scientific and humanitarian. The search tool to prepare the yard tool to measure perceived self-efficacy based on measurements and previous literature on the subject of perceived self-efficacy. The researcher using a number of means, statistical, including test Altaúa and analysis of variance of bilateral and results showed the enjoyment of the research s

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Publication Date
Sun Jan 03 2016
Journal Name
Journal Of Educational And Psychological Researches
قياس جودة الحياة لدى طلبة جامعة بغداد
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This current study aims at recognizing the feelings of Baghdad University students towards life quality. The research variables are: gender (male, female), the academic specialization (science, humanities), the academic stage (2nd, 4th). To achieve the research aims, the researcher adopted Life Quality Scale of (Mensi and Kadhim 2006) which is consist of (56) items in its final figure in five alternatives. The researcher tested the psychometric features of the scale represented by validity and reliability. The scale has been applied on a sample of Baghdad University students that is contained of (240) students equally distributed in the Colleges of Engineering, Science, Arts, and Political sciences.

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Publication Date
Mon Apr 01 2019
Journal Name
Journal Of Educational And Psychological Researches
Life Management Strategies among Mosul University Academics
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The study aims to measure life management (in its various approaches) among   university academics and to identify the differences among life management strategies (in its various approaches) in regard of gender (male, female), field of education (scientific, humanitarian) and title (assistant lecturer, lecturer, assistant professor, and professor). The study sample consisted of (246) male and female academics from four colleges (Arts, Science, Science education, and Humanitarian Science Education). To achieve the goals of the study, the researchers used the Freund & Baltes (2002) life-management strategies scale after translating it and determining its parameters of reliability and validity. The statistical analysis of the

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Publication Date
Sat Feb 02 2019
Journal Name
Journal Of The College Of Education For Women
The use of ionic pumping method for improving the performance of vacuum micro-electronic valves: The use of ionic pumping method for improving the performance of vacuum micro-electronic valves
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Abstract
The use of electronic valves is commonly available. yet, the most
common is the techniques of communications as prod casting transmitter that
are used by these valves in addition to their use in communication tools as far
distance telephone, electronic measuring techniques , and others.
In this study, an attempt is endeavored for improving the efficiency of the
vacuum micro- valves(GI-19b) through activating their internal surfaces by the
use of ionic pumping which is used for treating valves which are out of order
(because of sedimentation some materials and oxide on its poles). The
existence of these materials and oxide increase the sum of current leakage
moving in between. The use of ionic pumpin

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