Summary:
Background: It is well known that the early removal of corpus luteum (CL) in pregnant women results in abortion . Defects in the function of CL lead to deficiency in the secretion of progesterone which adversely affect human embryo implantation .
Aim of the work: l)to determine progesterone concentration in the luteal phase defect (LPD) patients complaining from infertility and 2) to evaluate the clinical value of ovulation induction, sperm intrauterine insemination SIUT and luteal support therapy in the treatment of LPD patients.
Patients & Methods: One hundred and twelve LPD patients were involved in this study. The progesterone concentrations were performed by radioimmunoassay method on cycle day 21. Patients were considered to have severe LPD when progesterone concentration was 3.56 ng/ml and mild LPD when the progesterone concentration was less than 8.63 ng/ml. Those patients who had progesterone concentration of more than 10 ng/ml were considered normal (without LPD). Ovulation induction was induced by clomiphene citrate (lOOmg/day for five days) and human menopausal gonadotropin (300 international units for another five days) and human chorionic gonadotropin (HCG) treatments. Standard technique for in vitro activation of human sperm and sperm intrauterine insemination (SIUI) were performed. Following III I the patients were received 1500 IU of HCG on cycle day 14,17,20 and 23.
Results: The pregnancy rate in the severe LPD group was significantly lower (P<0.05) than that of control and mild LPD groups. The pregnancy rate in the control (without LPD) and mild LPD group was significantly not different (P>0.05). This indicates that the outcome of luteal support therapy following ovulation induction and SIUT was significantly improved when compared to control group .
The specialized Journalism plays an important role in our daily lives using all of its different ways, including news, caricature, commentary and dialogue. The specialized Journalism deserves vigilance and interest for it is caring about having a new media system. It is meant by “specialization”, first: identifying the areas of work in which the person concerned possesses great knowledge in the specialty resulting from a long experience, it also means being able to continuously develop required skills in that specialty. The specialization is not only a feature of the press, but also a feature of human development; thousands of years ago, the primitive society consisted of people from different specializations: fishermen, farmers, her
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