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iqjmc-1649
HLA ANTIGENS OF ARAB CHRISTIANS IN IRAQ
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BACKGROUND: Iraq had more than twenty-four millions inhabitants of populations. This nation is one of the most populated countries in the world. It is difficult to define Iraqi populations genetically (HLA polymorphism) because they are structured of a mixture of many groups. HLA phenotype frequencies that encoded by many closely linked genes that are responsible for a variety of cell surface alloantigen proteins that are responsible for differences in different ethnic groups. Arab Christians in Iraq, accounting for more than three millions inhabitant mostly the northwest and other parts of Iraq. This raised the need for a preliminary study of the HLA trend in this population. Aim of study:
1- Estimating the gene frequency of HLA class I (A, B, Cw) and class II (DR and DQ) alleles in Iraqi Arab Christians.
2- Assessing the genetic relationship between Iraqi Arab Christians and other Arabian, Asian and European populations.
Materials and Methods: A total of unrelated 568 Iraqi Arab Christians (AC) healthy volunteers and individuals referred to Immunology and Tissue Typing Center in Al- Karamah Teaching Hospital for organ transplantation and Forensic medicine) were examined for HLA polymorphism using complement dependent cytotoxicity test from June-2003 to April-2004.
Results and conclusions: The phenotypes of all loci of (AC) were in agreement with Hardy-Weinberg equilibrium. In case of HLA-A locus, three variants dominate this locus Al(0.123), A2 (0.149) and A3(0.134) which showed some similarities with Arabian , Asian and European people in the world. A3 had been found to be associated with Hereditary Hemochromatosis (HH) but the risk increased when there is a linkage disequilibrium between A3/B14. Fortunately, BI4 allele had a low frequency in this group and common allele was B35(0.154) and 851(0.128) which had an association with Behqet 's syndrom. So one can predict high incidence of this disease in this group of population. Last locus was studied in class I was Cw4 that had a higher rate (0.173) in HLA -Cw loci.
In case of class II, it was done on small number of persons and the common allele was DR2(53.84%) which is protective from insulin dependent diabetes mellitus disease while DQ1 is common allele in HLA-DQ loci.
HLA typing of (AC) had some similarity with Arabian people because of their same ancestry and also had some similarity with Caucasoid Europeans because of outbreading and intermixing with those populations due to migration.

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Publication Date
Sun Oct 02 2005
Journal Name
Journal Of The Faculty Of Medicine Baghdad
possible association of HLA class-1 molecules with rheumatoid arthritis in Iraqi patients
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Background:

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Publication Date
Mon May 31 2021
Journal Name
Iraqi Geological Journal
Effect of Shatt Al-Arab Salinity on the Groundwater of Al-Fao and Al-Siba in Southern Iraq
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This study was conducted to estimate the extent of damage to the population in Basra, southern Iraq, specifically the areas adjacent to the Shatt al-Arab and the Arabian Gulf, which are the Al-Fao district and the Al-Siba region. They are affected by the progression of saline water resulting from the lack of water imports and the Karun River interruption, which led to high concentrations of salts in the Shatt Al-Arabs. Consequently, its effect on lands and all life types in these areas requires correcting a map of the study area to drop the groundwater sites as well as calculate the total dissolved salts, electrical conductivity and pH. This study concluded that the groundwater contains very high percentages of total dissolved solid

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Publication Date
Fri Jan 01 2016
Journal Name
Iraqi Geological Journal
Assessment of heavy metals contamination and sediment quality in shatt al-arab river, S Iraq
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Publication Date
Wed Apr 01 2009
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients
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Background: genetic factors were considered to play a possible role the development of autoimmune hepatitis.
Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: comparison between AIH patients and healthy controls showed several antigens deviations in their frequencies. HLA-A*113 (A1/-/Null) observed to play a possible risk factor in this disease while significant loss of HLA-A*2 allele were clearly observed which prompt us to believe that it could act as a protective factor, on the other hand, increased frequency of HLA-B*8 & B*14 were statist

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Publication Date
Sun Jul 04 2010
Journal Name
Journal Of The Faculty Of Medicine Baghdad
HLA prevalence in Iraqi patients with ischemic heart disease.
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Background: The etiology of ischemic heart disease (IHD) is believed to have an immunological component. Association with human leukocyte antigens (HLAs) has been previously reported, particularly with DR6.
Patients and methods: 75 cardiac patients were admitted to the coronary care unit, Baghdad Teaching Hospital over the period October 2008-May 2009 with the clinical diagnosis of acute
coronary syndrome and STEMI myocardial infarction their ages range was (25-82) years the number of male was (55) (73.3%) and female was (20) (26.7%). All cases have routine ECG, cardiac marker’s measurements, routine haematological, Biochemical test and 2mls of blood reserved for HLA study.
Results: It was found that H

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Publication Date
Thu Apr 18 2019
Journal Name
Al-kindy College Medical Journal
HLA-DRB1*03 And DRB1*15 Frequency In Helicobacter Pylori Superficial Gastritis
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Background: Background: Helicobacter pylori is an important gastrointestinal bacteria related to the development of  superficial atrophic gastritis, peptic ulcer and gastric cancer. Human leukocyte antigens (HLA) may play an important roles in host immune responses to H pylori antigens.

Aim of the study: to investigate the association between HLA-DRB1 genotypes and superficial gastritis with H. pylori infection in an Iraqi patients.

Patients and methods: Sixty patients with superficial gastritis and 100 individuals with apparently normal results after endoscopic examination were recruited from Al-Kindy Teaching Hospital - G

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Publication Date
Wed Jan 02 2008
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The possible Association of HLA Class II with Bladder Cancer in Iraqi Patients
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Background: - Genetic Factors have a major role in the development of bladder cancer.
Objectives: - This study was carried out to shed a light on the possible association of HLA class II antigens and BC patients and to correlate this finding with the family
history.
Patients and Methodes :- Lymphocytotxicity assay had been used to assess HLAtyping of 65 BC patients and 50 healthy controls.
Results:- comparison between BC patients and healthy controls showed several antigens deviations in their frequencies. HLA-DR1, HLA-DQ1 and HLA-DQ3 antigens
were observed with increased frequencies in patients group with significant differences (P=0.000, 0.000 and 0.017 respectively). Moreover there was decrease

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Publication Date
Mon Aug 01 2022
Journal Name
Baghdad Science Journal
Application of GIS technique in the studies on fish assemblages in Shatt Al-Arab River, Basrah, Iraq
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The present study has examined the spatiotemporal varieties of the demographics of the Shatt Al-Arab River fishes and their relation to some ecological components. The aim is to forecast these groups in the unexplored parts of the waterway with an emphasis on environmental indices of diversity. Three sites in the river were selected as an observation and study of these species, which lasted from March 2019 to February 2020, the study dealt with factors affecting fishes, as Water Temperature (WT), Dissolved Oxygen (DO), Potential Hydrogen Ion (pH), Salinity (Sal), and Transparency (Tra). Gill nets, cast nets, hooks, and hand nets were adopted to collecting fish. The results indicated that the fish population comprises 60 species represent

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Publication Date
Sun Apr 02 2006
Journal Name
Journal Of The Faculty Of Medicine Baghdad
possible association of HLA class-1 molecules with colorectal cancer in Iraqi patients
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Background:

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Publication Date
Sun Dec 30 2012
Journal Name
Al-kindy College Medical Journal
Human Leukocyte Antigens Assosiation with Systemic Lupus Arythematosus In Iraqi Patients
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Background: The etiology of Systemic lupus erythematosus seems to be multifactorial including environmental as well as genetic factors. The genetic predisposition was supported by the occurrence of Systemic lupus erythematosus in more than one member of a family as well as in identical twins.
Aim of the study: To determine the human leukocyte antigen typing class I (A and B) in patients with Systemic Lupus Erythematousus disease.
Methods: Patients group consisted of 44 Iraqi Arab Muslims patients with Systemic lupus erythematosus disease who presented to Baghdad Medical City from January 2010 to January 2012 from Baghdad Province. The second control group consisted from 80 Iraqi Arab Muslims volunteers from hospital employees and t

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