Back ground: Oxidative damage has been suggested to play a key role in accelerating inflammation and to be involved in the pathogenesis of rheumatoid arthritis (RA) and
osteoarthritis (OA). Many studies had shown that those patients have low antioxidants level and are at risk of increased oxidative stress.
Objective: This study was designed to examine the levels of serum Total Antioxidant Status (TAS). Malondialdehyde (MDA) as index of lipid peroxidation and C–Reactive Protein (CRP) as a
marker of oxidative stress in patients with RA and OA and compared them with healthy control.
Method: Serum TAS , MDA and CRP levels were measured in 16 RA and 24 OA patients and compare with those obtained from 25 healthy controls.
Results: Serum TAS were significantly lower in RA group than in the OA and control groups (P < 0.05). Serum MDA and CRP levels were significantly higher in patients with RA than in those
with OA and healthy subjects (P< 0.05). There were significant negative correlations between TAS and MDA, CRP levels (r = -0.850; p < 0.001) and ( r = -0.498; P < 0.05) respectively and a
positive correlation between MDA and CRP levels in the RA group (r = 0.686; P < 0.01). In OA group, the level of CRP was significantly increased (P< 0.05) and there was significant
positive correlation between age and MDA level (r = 0.553; P < 0.01).
Conclusion: Our results demonstrated that levels of lipid peroxidation are increased in patients with RA compared to controls and patients with OA , In addition serum TAS levels were
decreased in RA. Serum TAS levels may be used as a routine and rapid test to verify the levels of oxidative stress in RA. Furthermore correlating TAS and MDA levels with a cute phase reactants such as CRP may give some clues about disease activity in RA .
Preparation and Identification of some new Pyrazolopyrin derivatives and their Polymerizations study
In this paper further properties of the fuzzy complete a-fuzzy normed algebra have been introduced. Then we found the relation between the maximal ideals of fuzzy complete a-fuzzy normed algebra and the associated multiplicative linear function space. In this direction we proved that if is character on Z then ker is a maximal ideal in Z. After this we introduce the notion structure of the a-fuzzy normed algebra then we prove that the structure, st(Z) is -fuzzy closed subset of fb(Z, ) when (Z, , , ) is a commutative fuzzy complete a-fuzzy normed algebra with identity e.
The objective of this paper is to show modern class of open sets which is an -open. Some functions via this concept were studied and the relationships such as continuous function strongly -continuous function -irresolute function -continuous function.
In this paper, estimation of system reliability of the multi-components in stress-strength model R(s,k) is considered, when the stress and strength are independent random variables and follows the Exponentiated Weibull Distribution (EWD) with known first shape parameter θ and, the second shape parameter α is unknown using different estimation methods. Comparisons among the proposed estimators through Monte Carlo simulation technique were made depend on mean squared error (MSE) criteria
(1)