Background:
Angiogenesis plays a crucial role in tumorigensis; several reports have described a significant increase in microvessel density (MVD) in colorectal carcinogenesis There are
several methods to measure the angiogenesis in neoplasms, but immunohitochemistry seems to be the mainstay of all. This method enable us to measure the tumor microvessel densities highlighted by using antibodies directed against endothelial cell markers like CD31,CD34 or others; then assessment of MVD by manual count of the number of microvessels in what appears to be the most vascular area of the tumor(called the hot spot) using a protocol described by Weidner et al.Automated cellular imaging system is used to analyze
immunohistochemically stained slides .studies have shown that the device offers accurate precision and reproducibility of immunostained slide analysis exceeding that possible with
manual evaluation which was the prevalent method.
Aims of the study:
To assess the angiogenesis in normal, adenomatous (benign) and malignant colorectal tissues using CD34 and the microvessels will be measured both manually by hot spot
method as the MVD and by the use of computerized image analysis system as fraction area ,we correlate between microvessels density and fraction area with various
clinicopathological parameters in colorectal cancer (CRC), and to a compare between the results which obtained from both methods.
Methods:
Paraffin embedded archival materials from 50 cases including three normal resection (non tumoruos) margins, 12 benign colonic lesions and 35 colonic adenocarcinoma were
used . 5mm section were cut and they were stained by anti CD34 antibody Angiogenesis was measured as MVD by two methods : manually by light microscope and by a computer
image analysis system (as fraction area). Then the MVD and fraction area were correlated with different clinicopathological parameters.
Results :
This study demonstrate that there is a statistical difference in MVD and fraction area in both hot spot method and CIAS respectively between benign and malignant tumors . P value
< 0.05 in hot spot method and less than 0.001 in CIAS and there was highly significant correlation between MVD and fraction area with the grade . There was significant increase
in MVD and fraction area from well differentiated to moderately differentiated and to poorly differentiated .There was no significant correlation between MVD and lymph node
involvement by hot spot method but CIAS proved a significant correlation between fraction area and lymph node involvement.Both methods (hot spot and CIAS) proved no
significant correlation with age , sex , size of the tumor , site of the tumor , stage of the tumor and the number of lymph node involverment.
Nowadays, still images are used everywhere in the digital world. The shortages of storage capacity and transmission bandwidth make efficient compression solutions essential. A revolutionary mathematics tool, wavelet transform, has already shown its power in image processing. The major topic of this paper, is improve the compresses of still images by Multiwavelet based on estimation the high Multiwavelet coefficients in high frequencies sub band by interpolation instead of sending all Multiwavelet coefficients. When comparing the proposed approach with other compression methods Good result obtained
Computer modeling has been used to investing the Coulomb coupling parameter ?. The effects of the structure parameter K, grain charge Z, plasma density N, temperature dust grain Td, on the Coulomb coupling parameter had been studied. It was seen that the ? was increasing with increasing Z and N, and decrease with increasing K and T. Also the critical value of ? that the phase transfer of the plasma state from liquid to solid was studied.
The main purpose of the paper is to identify the controllability of an existing production system; yogurt production line in Abu Ghraib Dairy Factory which has several machines of food processing and packing that has been studied. Through the starting of analysis, instability in production has been found in the factory. The analysis is built depending on experimental observation and data collection for different processing time of the machines, and statistical analysis has been conducted to model the production system. Arena Software is applied for simulating and analyzing the current state of the production system, and results are expanded to improve the system production and efficiency. Research method is applied to contribute in knowi
... Show MoreSystemic lupus erythematosus (SLE) is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues. Aimes of study determination of integrin- linked kinase 1(ILK-1) and anti-smith antibody(ASAB) levels in serum of Iraqi patients with systemic lupus erythematosus, in addition, that ILK-1 may be as a diagnostic marker of SLE disease, and study the effect of systemic lupus erythematosus on renal function in these patients. This study included 100 females’ patients with systemic lupus erythematosus attending to the Rheumatology Unit in Baghdad Teaching Hospital, Medical City, (Baghdad), in addition to 30 healthy females as controller group were chosen without any chr
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... Show MoreHealth and safety problem can be described by statistics it can only be understood by knowing and feeling the pain, suffering, and depression. Health and safety has a legal responsibility to protect it for everyone who can affect in the workplace. This includes manufacturers, suppliers, designers and controllers of work places and employees. Work injury is one of the major problems in manufacturing and production systems industries; it is reduced production efficiency and affects the cost. To gain flexibility from a traditional manufacturing system and production efficiency, this paper is about the application of estimating technology to preview and synthesis of Lost Time of Work Injuries in industry systems aims to provide a safe workin
... Show MoreBackground: Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology characterized by joint inflammation and the presence of autoantibodies, mostly Anti-cyclic citrullinated peptide antibody (ACCP) which are released when the body loses its ability to distinguish between self and foreign molecules. Serum amyloid A2 (SAA2) is an acute phase protein produced in response to inflammatory conditions including RA.
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Patients and methods: A case control study, on a to
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