Background
Sildenafil has been used in the treatment of erectile dysfunction (ED). However it has the disadvantage of many visual disturbances. The aim of this work is to study the effect
of sildenafil on diabetic patients which might have ocular problems due to diabetes mellitus.
Materials and Methods:
A total of 30 subjects were enrolled in the study, they were divided into two groups. The control group consisted of 10 healthy subjects but complaining of ED only and the
other (20 patients) had diabetes mellitus and ED as well. All subjects had ocular tests done before and after sildenafil intake. It was obvious that sildenafil changed visual tests from totally normal for controls, before treatent, to visual abnormality in some of the tests after treatment, such as in colour Fac Med Baghdad sense , diplopia & intra ocular pressure ( IOP ).
Results:
While certain percentage of diabetic patients had visual disturbances even before sildenafil intake. The abnormalities were in visual acuity, visual field and, in fundus
appearance. Post – treatment led to increase the percentage of patients with already existing ocular problems and extend them to include some other new ones like change in colour
sense , diplopia and increased ( IOP ).
Conclusions:
Comparing the patient group with the control , pre – treatment tests revealed that diabetic patients had already pre – existing ocular problems due to diabetes such as in the
visual acuity , visual field which were statistically not significant ( p>0.05). The only significant (p<0.05) difference was in the fundus appearance. Post – treatment results indicated more ocular damage in diabetic patients as all tests were abnormal compared to control subjects. So, although not significant but ocular complications do exist and might cause unpredictable eye damage to certain percentage of patients which should be taken into consideration.
The current study was conducted to investigate Annona fruit pulp effects on the levels of various physiological biomarkers linked with insulin-dependent diabetes mellitus after disease induction in mice, as well as indications of oxidative stress and male hormones. The rats were separated into four groups, three of which were given Alloxan (90 mg/kg body weight) to induce diabetes, while the fourth served as a negative control. The first group of diabetic mice received no therapy, the second received metformin (600 mg/kg body weight) and the third received Annona fruit puree. The mice were sacrificed at the end of the experiment, to acquire blood and tissue samples from the liver, kidneys and spleen. The first untreated gro
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... Show MoreBackground: Diabetes mellitus is one of the commonest chronic disorders worldwide with a rapid rise in prevalence. In Iraq its prevalence is high especially in elderly age group. Patients with type 2 diabetes mellitus have higher vulnerability for complications, whether microvascular or macrovascular. Ocular complications are common in diabetes mellitus, and comprise diabetic retinopathy, diabetic papillopathy, cataract, glaucoma, dry eye disease and diabetic keratopathy. Diabetic keratopathy involves endothelial and epithelial tissues of the cornea, leading to persistent epithelial defect, corneal erosion, or corneal ulcers.
Aim of the Study: To compare the mean corneal endothelial cell count between patients wi
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... Show MoreHepatitis, a condition of liver’s inflammation that can be self-limiting or, in certain chances, it may lead to liver cancer, fibrosis or cirrhosis. Hepatitis viruses mainly cause hepatitis in the world. People with hepatitis C have predominant chances to develop diabetes as HCV virus participates in causing type 2 diabetes. HCV virus causes pathogenesis in two ways: it either directly destroys the β cells of pancreas or contributes to the specific autoimmunity of β cells. The present cross sectional study was done in Wazirabad Tahsil of Gujranwala District to analyze the percentage of patients suffering from hepatitis C who had the risk of diabetes mellitus. For this research work, demographic information and data about any other me
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Methods: - Microorganisms were isolated and identified from both superficial & deep foot ulcers infection of (60) diabetic patients.
Results: - The present results showed that high incidence (30.8%) of Escherichia coli (E-coli) was isolated from dry - superficial foot ulcers followed respectively by Staphylococcus epidermidis (S. epidermidis). 3.1 % and 15.4% of Proteus mirabilis (P. mirabilis), equal Percentages for Klebsiellae Pneumoniae (K. pneum
Diabetic Nephropathy(DN) is a complex disease manifested by persistence microalbuminuria occurring due to the interaction between hemodynamic and metabolic pathway that activates the local renin-angiotensin-aldosterone system resulting in a decline in renal functions.
This study aimed to quantify the associations between serum aldosterone concentration and fetuin- A as a marker of calcification in type 2 diabetic patients with and without microalbuminuria from one side, and study the possible relationship between aldosterone and fetuin-A with glycemic indices, serum electrolyte, renal function and microalbuminuria and body mass index from the other side.
A case-control study involved eighty-six adult subjects
... Show MoreElevated C-Reactive Protein (CRP) level in serum is a risk factor for type 2 diabetes ,this relationship is likely to be the cause it means elevated CRP leads to T2D in future . Our objective was to examine CRP in male Type 2 Diabetes(T2D) patients in different age ,we studied 120 male subjects divided to two groups according to their age. First group A age (31 - 40) year old ,60 person )30 control & 30 T2D patients(,3 person for each same age: second group B age (41 – 50) years old ,60 person )30 control & 30 T2D patients(,3 person for each same age. We examined blood sugar ,cholesterol and CRP in each group. and we toke the mean of samples in the same age in each data in all the 4 groups. Our data shows that CRP
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... Show MoreStudy aimed to determination of chitotriosidase-1 levels in Iraqi diabetic and diabetic patients with thyroid disorder. Also, study aimed to found relation correlation for chitotriosidase-1 with FSG, T3, T4 and TSH. Ninety subjects were including in this study. First group consisted of (30) healthy individuals who have no history of any thyroid disorders or diabetes mellitus as control group. Second group (G2) (n=30) patients with diabetic and hyperthyroidism as association disease, and third group (G3) (n=30) include patients with diabetic and hypothyroidism as association disease. Serum used in (FSG, T3, T4, TSH, and Chitotriosidase-1) determination. Results showed a significant elevation in patients’ groups (G2, G3) comparing t
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