Background: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of histiocytes encompasses a wide clinical spectrum, ranging from a benign localized disease to acute
generalized disease with fatal outcome.
Objectives: to retrospectively evaluate clinical characteristics at diagnosis and outcome of patients with Langerhans cell histiocytosis.
Patients and methods: A retrospective analysis of data on 21 children with Langerhans cell histiocytosis followed at Oncology unit, Children Welfare Teaching Hospital, Medical City,
Baghdad, between 1999 and 2006.
Results : The age at time of diagnosis of LCH ranged from 3 months to 9 years, with a median of 22 months, and male to female ratio was 1:1.1. The duration of the onset of the disease before diagnosis ranged from 1month to1 year. Bone lesions, skin lesions and LAP were the common presenting features. Skull was the major site of lytic lesions 10(47.6%) patients. Tissue biopsy and/or aspiration were the main diagnostic procedures. Twenty patients treated by different combinations of chemotherapy. Ten patients survived (50%), and the mean time of follow up was 28 months.
Conclusion : The study showed a relatively high incidence of advanced (III and IV) stages of disease 12 patients (57.1 %) with subsequent poor outcome and survival.
Recommendation : Long term follow-up by a multidisciplinary care team is required
Background: Prognostic histological evaluation of many cancers have recently concentrated on angiogenesis.
Materials &Methods: A total of twenty formaline-fixed, paraffin embedded blocks of renal cell carcinoma were included in this study. Sections were subjected for immunohistochemical staining of CD34. The median of the MVD of all cases of RCC were obtained to divide the cases into high- and low-MVD score groups and were correlated with the tumor stage and grade.
Results: there was a significant correlation of the high MVD score with tumor stage (P=0.02).
Conclusion: MVD may be considered as a potential prognostic marker for RCC.
Background: Day case surgery has become widely accepted as a safe alternative to the inpatient care in up to 70% of the cases at a children’s hospital. It has the advantage of minimizing the psychological trauma of hospitalization, decreasing nosocomial infection, less costly and frees up hospital beds.Objectives: To assess the advantages and disadvantages of this type of surgery.Methods: this is a prospective study, in which two hundred thirty childhood tonsillectomies were performed as a day-case in the department of otolaryngology at Al Shaheed Gazi hospital, Medical City Complex during the period from October 2009 to September 2010. The patients age range from 3-12 years (Mean 7.2 years).Results: 46.08% males and 53.91% females wer
... Show MoreBACKGROUND:Gastrointestinal bleeding (GIB) in infants and children is one of the more alarming conditions encountered in pediatrics. It is nonetheless an anxiety-provoking complaint. Most etiologies are self-limited and benign.
AIM OF STUDY:To review the causes of upper gastrointestinal bleeding and its clinical presentations in children and evaluate the role of endoscopy for diagnostic and therapeutic purposes.
PATIENTS AND METHOD:Fifty eight patients from 4 days old up to the age of 18 years who referred with upper gastrointestinal bleeding to the Gastro intestinal&Hepatology unit in the Children Welfare Teaching Hospital/ Medical City/Baghdad, in the period from 1st of April 2010 to 1st of November 2010.
RESULTS: there we
Background: vomiting is a very common symptom of disease in childhood, it occurs both in gastrointestinal and non-gastrointestinal diseases.
Objectives: Our aim of the study was to find out the causes of vomiting in different age group, the improper management of vomiting in daily practice and to emphasis on the usefulness of imaging study in the diagnosis.
Methods: A prospective study was carried out on patients presented with vomiting admitted to Children Welfare Teaching Hospital from the first of Dec. 2001 to the end of April 2002 .The age ranged between early neonatal periods to 12 years of age.
Reults: A total of 100 child were included in this study,(65) male (35) female male to female ratio
The development of better tools for diagnosis and more accurate prognosis of cancer includes the search for biomarkers; molecules whose presence, absence or change in quantity or structure is associated with a particular tumour or prognosis/therapeutic outcome. While biomarkers need not be functionally relevant, if cell survival, then they could also provide new targets for therapeutic drugs. In recent years attention has been applied to a group of proteins known as cancer testis antigens (CT antigens) [1]. These proteins are products of genes whose expression was normally confined to the testis, yet they are expressed in tumour cells. CT genes are bound to serve a wide array of roles in the testes, which have many highly differentiated cel
... Show MoreMalignant renal neoplasm: Because benign tumors of kidney are rare, so it is a good rule that all neoplasm of kidney which are recognized clinically should be treated as malignant. They are uncommon between the ages of 7&40(l).Rcna! cell carcinoma is the most common tumor of the kidney in adult. It arises from renal tubular cells.. It is rare in children &is more frequent in men than women. It is an adenocarcinoma &is the most common neoplasm(75%) of kidney. The tumor may invade loca!Iy& metastasize by way of blood stream &the lymphatics. Regional lymph nodes are involved in approximately 30% of patients, unfortunately sign &symptoms are usually meager until the disease is advanced. Gross haematuria is the most fr
... Show MoreBackground: Hypertension occurs in some patients with primary nephritic syndrome it may be mediated by changes in vasopressin activities or intravascular volume.
Aim of study: is to find out how many patients with idiopathic nephritic syndrome hare hypertension. Subj. & Methods: The study included 50 children (29 males and 21 females) with age ranger between
1- 13 years. Sixteen patients (32%) were with initial attack of nephritic syndrome, while thirty four patients (68%) presented with relapse.
Results: Nine (18%) patients had hypertension, eight (16%) patients were relapse cases, and one (2%>) patient was with initial attack. Hypertension was found in four (8%) patients with steroid resistant neurotic syndrome, three (
This research aims to identify the following :
- The reading willingness skill to kindergarten children.
- There is no statistical significance difference between average scores of reading willingness skill of the sample individuals as a whole, and the hypothetical average of the scale.
- The difference in reading willingness skill to kindergarten children according to gender variable (male & female).
- There is no statistical significance difference between average scores of reading willingness skill for kindergarten children according to gender variable (male & female).
To achieve the research goals, the researc
... Show MoreTuberculosis continues to be the leading cause of morbidity and mortality, with an estimated annual incidence of 10.4 million worldwide. It has been estimated that 10% of patients with extrapulmonary tuberculosis have musculoskeletal involvement, with the spine being the most common. Spinal tuberculosis (TB) accounts for 50% of cases of musculoskeletal tuberculosis.
Spinal tuberculosis is the result of infection with Mycobacterium tuberculosis. It is a secondary infection, the primary lesion of which is in the lungs, genitourinary system, or gastrointestinal tract and can be active or latent. Involvement of the vertebral segment is the result of hematogenous spread of infection along the arterial pathway or Batson's vei
... Show MoreBackground: First six to twelve months after initial urinary tract infection, most infections are caused by Escherichiacoli, although in the first year of life Klebsiella pneumoniae, Pseudomonas, Enterobacter spp andEnterococcus spp, are more frequent than later in life, and there is a higher risk of urosepsis compared with adulthood
Objectives: To determine the prevalence of bacterial isolates from Urinary Tract Infections of children at a children hospital in Baghdad and their antimicrobial susceptibility patterns.
Type of the study: Cross-sectional study.
Methods: During six months of study (1 June to 31 Dece
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