Background: CA19-9 is among a group of mucin glycoprotein sialosyl lewis antigen (SLA) having come to be recognized as a circulating cancer associated antigen for gastrointestinal cancer. Basic research into cancer causation will be a powerful determinant of intervention in the transformation process reinforcing the need for developing effective molecular tumor biomarkers for early detection of malignant evolution in tissues of organs i.e. stomach, colon and rectum. In this study, we make a comparsion between the levels of CA19-9 in sera and tissues of patients with these diseases to see if their levels are proportional and if it is a tumor marker that affect with malignant cells in tissues of these organs.
Patients and methods: Carbohydrate antigen 19-9 (CA19-9) levels were measured in sera and tissues’ of 8 patients with stomach cancer (G1), 8 patients with colon cancer(G2), 8 patients with rectum cancer (G3) and 30 healthy subjects (G4), by the enzyme-linked immunosorbent assay (ELISA) technique.
Results: The results of CA19-9 levels in sera were (42.625±33.088; 47.013±0.318 and 10.938±0.979)U/ml for G1, G2 and G3 respectively compared with serum CA19-9 level of G4, which
was 7.74±4.92 U/ml. The results were found to be significantly higher than control group (p < 0.005).The results of CA19-9 levels in tissues’ homogenate were (1170.25±8.45; 535.75±263.46 and 483.75±16.37)U/ml for G1, G2 and G3 respectively. The results revealed significantly higher levels of CA19-9 in tissue’s homogenate of each patients group compared with the serum levels of the same patients (p < 0.005).
Conclusions: Normal level of CA19-9 were found in sera of rectum cancer patients compare to the cutoff value 37U/ml in literatures 1,2, but it is significantly higher than our control group. , Significant high levels of CA19-9 were found in sera of colon cancer patients. , Sera of stomach cancer patients showed elevation in CA19-9 level in 50% of cases. , Significant high levels of CA19- 9 were found in tissue’s homogenate of rectum, colon and stomach cancer patients compared to its levels there serum.
Psoriasis is a common, chronic, immune mediated disorder.The disease is arising as a result of dysregulated interactions of the innate and adaptive immune system in the context of skin epithelium and connective tissue. The biological drug Etanercept(ETN) approved for use in treated psoriasis. ETN is tumor necrosis factor- α (TNF-α) inhibitor. In this study, 48 psoriatic patients were taken before and after treatment who attended to the Dermatology and Venereology Department in Baghdad Teaching Hospital during the period from December 2016 to September 2017and 50 samples were used as healthy control group. The results showed that most psoriatic patients 52.08 % were within the second
... Show MoreAN Salih, LO Hamza, Ann. For. Res, 2022 - Cited by 2
Background: Quality of life in brain tumor patients is an emerging issue and has prompted neurosurgeons to recon¬sider the need for cognitive assessment in the course of treatment. To date there has been a lack of comprehensive neuropsychological assessment performed preoperatively and in the acute postoperative period in our hospitals.Objectives: to establish the effects of tumors and their surgical treatment, from a neuropsychological perspective, on cognitive functioning in patients with cerebral Gliomas. Methods: This is a prospective study conducted in the Neurosurgical Hospital in Baghdad, Iraq, during the period from January 1999 to January 2001. Any patient admitted during the period of the study with clinical history, signs, sy
... Show MoreTotal protein and total fucose were determined in sera of thyroid
disorder patients.
Sera of (40) diagnosed by consultant hyperthyroidism, and 40 hypothyroidism were analyzed for the above parameter for control, sera of (40) normal individuals were used.
They were healthy with no appearing disorder results analysis revealed no significant differences (P<0.05) in the (mean ±SD) of total protein values in sera of hyper and hypothyroidism were compared
... Show MoreBackground: Diabetes mellitus and osteoporosis are two common medical disorders that are becoming more common as the population ages. T2DM patients have a higher fracture hazard, having a high BMD, which is primarily due to the raise hazard of falling. Macrophage colony-stimulating factor (M-CSF) is one of the hematopoietic growth factor family, and It plays an important function in fracture repair by attracting stem cells to the fracture site and influencing the production of hard calluses by promoting osteoclast genesis.Aims of study: The purpose of this research was to assess the blood level of macrophage colony-stimulating factor in Iraqi osteoporotic patients with and without type 2 diabetes. in addition, that M-CSF may be a predictiv
... Show MoreRheumatoid arthritis (RA) is an autoimmune disorder of the joints that is characterized by extra-articular involvement in addition to inflammatory arthritis. Joint and periarticular tissue loss brought on by inflammation results in functional impairment. To lessen the significant daily challenges that patients confront and to ensure better outcomes, early detection and treatment are essential. The study's objective was to establish the use of human β-defensin-2 (HBD-2) as a RA diagnostic marker. A total of 60 RA patients and 30 healthy controls participated in the research. The ELISA technique was used to measure serum HBD-2. The following tests were performed: complete blood count (CBC), erythrocyte sedimentation rate (ESR), renal func
... Show MoreBy measuring Adropin, fasting blood glucose (FBG), cholesterol, high-density lipoprotein (HDL), triglycerides (TG), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) in the sera of Iraqi patients with MetS and type 2 diabetes mellitus (T2DM), the current study was designed to compare some crucial markers in metabolic syndrome (MetS) sera and diabetic patients (T2DM) with control. Twenty female subjects were divided into three groups: group I=40 with MetS and group II=40 with T2DM, and 40 healthy subjects were employed as a control group. Compared to the control group, Adropin levels in the Mets group and T2DM group decreased significantly (p < 0.05). In contrast, none of the patient groups (MetS and T2DM)
... Show MoreThis study focused on determining the markers of Macrophage migration inhibitor (MIF), as well as the N-telopeptides of type I bone collagen (NTX), and some other parameters (alkaline phosphatase (ALP), vitamin D (Vit D), calcium (Ca), phosphorus (P), and magnesium (Mg), and their correlation with other parameters in osteoporosis. One hundred ten subjects were involved in the current study. There were two groups of patients: group I (30) women with severe osteoporosis and group II (30) women with mild osteoporosis. For comparison, 50 apparently healthy individuals were included as a control. Serum levels of MIF, and NTX were significantly higher in groups I and II as compared to the control group, which indicate that these two parameters
... Show MoreToxoplasma gondii is an opportunistic parasite in immune-compromised persons. The prevalence of toxoplasmosis in psoriasis patients is investigated. In addition, the treatment effect on psoriasis patients infected with toxoplasmosis through evaluating Tumor Necrosis Factor-α (TNF-α) cytokine levels is studied. Blood samples were collected from 130 individuals who involved 60 control samples and 70 samples with psoriasis. They attended Medical City Hospital in Baghdad province from October 2017 - February 2018. Then, the anti- T. gondii antibodies (IgM and IgG) and TNF- α in the sera were determined via the enzyme linked immune-sorbent assay. The highe
... Show More