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Magnetic resonance imaging in assessment of liver lesions in patients with extrahepatic primary cancer

Background: Liver imaging is commonly undertaken in patients with cancer history because, after lymph nodes, the liver is the most frequently involved organ by metastases
Objectives: The aim of the study was to evaluate the role of liver MRI (magnetic resonance imaging) in characterization and detection of liver lesion in patients with extrahepatic primary
Methods: this is a cross sectional study of 70 patients with extrahepatic liver primary cancer who had their treatment in oncology teaching hospital underwent routine abdominal ultrasound to detect liver lesion(s) and suspicious cases then referred to MRI which was done in Ghazi Alharri and oncology teaching hospital from the period from 1st of September 2015 to end of November 2016, the patients age range from 31 to 75 years
Results: hemangioma is the most common solitary liver lesion in patients with extrahepatic primary cancer which represent 27% of lesions detected followed by simple cyst which represent 13% of the lesions, in another hand solitary metastasis seen in 7% of solitary lesions while metastasis is the leading cause behind multiple hepatic lesions and represent about 38% of lesions seen ,unlike solitary lesions, hemangioma is a rare cause and seen in 7% of cases
Conclusion: MRI is a required adjuvant tool in evaluation of suspicious liver lesion ,its value was illustrated in characterization and diagnosis of liver lesions depending on their appearance in T1 ,T2 and fat suppression T2 sequences in addition to assess their enhancement pattern after dynamic IV( intravenous) contrast injection.

الخلفية: يتم عمل تصوير الكبد عادة للمرضى الذين يعانون من السرطان، لأنه العضو الأكثر اصبابة بانتشار السرطان بعد العقد الليمفاوية.

المقدمة: الهدف من هذه الدراسة هو تقييم دور تصوير الكبد بالرنين المغناطيسي في كشفو توصيف افات الكبد في المرضى الذين يعانون من سرطان اولي خارج الكبد.

المرضى والطرق: هذة هي دراسة مقطعية ل 70 مريضا يعانون من سرطان اولي خارج الكبد والذين كان علاجهم في مستشفى الأورام التعليمي في مدينة الطب ثم خضعوا لفحص الرنين المغناطيسي في مستشفى الشهيد غازي الحريري  ومستشفى الأورام خلال الفترة من 1 سبتمبر 2015 إلى نهاية نوفمبر 2016 وهم من الفئة العمرية بين  31-75 عاما.

النتائج: يمثل الورم وعائي الدموي الأكثر شيوعا من الاورام الانفرادية في الكبد في المرضى الذين يعانون من سرطان خارج الكبد والتي تمثل 27٪ من الآفات اكتشفت يليه كيس بسيط والذي يمثل 13٪ من الآفات الانفرادية المكتشفة، من جهة أخرى انتشار الورم الاولي الوحيد يمثل 7٪ من الآفات الانفرادية، والعكس تماما حيث يكون السبب الرائد وراء الآفات الكبدية المتعددة ويمثل حوالي 38٪ من آفة الكبدد المتعددة ، في حين اخر ان الأورام الوعائية تمثل 7٪ من الحالات المتعددة.

الاستنتاجات: الرنين المغناطيسي هو أداة مساعدة ومطلوبة في تقييم الآفة الكبد المشبوهة، وتتجلى قيمته في توصيف وتشخيص آفات الكبد اعتمادا على مظهرهم في مقاطعT1 ، T2، ومقاطع T2قمع الدهون بالإضافة إلى تقييم نمط اخذها للصبغة بعد الحقن في الوريد والذي يسمي بالفحص الديناميكي .

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Publication Date
Wed Oct 18 2023
Journal Name
Iraqi National Journal Of Nursing Specialties
Assessment of Quality of Life for Patients with Permanent Pacemaker in Baghdad City

Objectives: To determine the (QoL) for patients with permanent pacemaker and to find-out the relationship between
these patients’ (QoL) and their sociodemographic characteristics such as age, gender, level of education, and
occupation.
Methodology: ٨ purposive non-probability” sample of (62) patient with permanent pacemaker was involved in this
study. The developed questionnaire consists of (4) parts which include !.demographic data form, 2.disease-related
information form, 3.socioeconomic data form, and 4.Permanent pacemaker patient’s quality of life questionnaire data
form. The validity and reliability of the questionnaire were determined through the application of a pilot study. ٨
descriptive statistical a

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Publication Date
Tue Dec 05 2023
Journal Name
Baghdad Science Journal
Cytotoxic Activities, Determining Toxin, and Molecular Docking of Ovary Pufferfish (Tetraodon leiurus) in Singkarak Lake as Cancer Chemoprevention Candidate

The primary toxin class discovered in freshwater pufferfish is a category of neurotoxins called PSTs (Paralytic shellfish toxins) and pufferfish toxin has been observed to have biological, biochemical, and cytotoxic effects on cancer cell lines. Therefore, it is crucial to determine the cytotoxic activity, toxins present in the ovary of T. leiurus, and interaction between ligand (toxin compound) and receptors test. This study used the MTT method in the T47D cell lines, liquid chromatograph-tandem mass spectrometry (LC-MS/MS), and analysis of the molecular interaction using molecular docking. The ovary of T. leiurus had cytotoxicity on the T47D cell, having an IC50 value of 229.535 μg/ml, and generated a chroma

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Publication Date
Sat Sep 30 2023
Journal Name
Journal Of The College Of Education For Women
Topic Management in Selected Dementia Patients' Speeches: A Clinical Discourse Analysis Study

Topic management is the awareness of how speakers deal with initiating, developing, changing, and ending a topic and how they fix the relationship when a misunderstanding occurs. It is such an important unit of conversation as it includes the transition from one strategy to the other to be accomplished in a systematic and orderly manner. These strategies are impaired in dementia patients thus lead to communication breakdown. This study aims at detecting the dementia patients' topic management strategies in selected speeches and answering the questions of which of these strategies are fully or partially detected in these speeches. The researchers use a qualitative method to examine the speeches of those patients and they adopt an eclectic

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Publication Date
Tue Oct 01 2019
Journal Name
International Journal Of Pharmaceutical Research
Study of aminoacy lt ran-synthetasecomplex interacting multifunctional protein 1 and liver enzymes in iraqi women with breast cancer undergoing chemotherapy

Breast carcinoma is one of the greatest popular neoplasms in females. It is a major reason of demise in the world, and it is the first cancer in ranking diagnosed in Iraqi women. This study aimed to determine aminoacyltRAN-synthetase complex interacting multifunctional protein 1 and liver enzymes levels in Iraqi females with stage II breast malignance, and study the effect of chemotherapy (after surgery) on these markers. This study included 50 females patients with stage II breast malignance (before and after surgery and second dose of chemotherapy) attending the Oncology Teaching Hospital in Medical City/ Baghdad, in addition to 20 persons as controller group were chosen without any chronic diseases. Their ages ranged from (30-55) years.

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Scopus
Publication Date
Tue Jun 25 2024
Journal Name
World Academy Of Sciences Journal
Expression of programmed death ligand 1 in patients with triple‑negative breast cancer: Association with clinicopathological parameters

The utilization of targeted therapy for programmed death ligand 1 (PD‑L1) has emerged as a prominent focus in contemporary clinical trials, particularly in the context of immune checkpoint inhibitors. The prognostic significance of the expression of PD‑L1 in invasive mammary cancer remains a subject of discussion in clinical oncology, requiring further exploration, despite its recognition as a biomarker for responsiveness to anti‑PDL1 immunotherapy. The present study was conducted to investigate the immunohistological expression of PD‑L1 in women with triple‑negative breast cancer (TNBC), with a particular focus for searching for the associated clinical and pathological characteristics. The present retrospective study examined the

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Publication Date
Sat Jun 30 2007
Journal Name
Al-kindy College Medical Journal
Lung Cancer in a Sample of Iraqi Patients

Background: Lung cancer is responsible for the most
cancer deaths in both men and women throughout the
world. Deaths from lung cancer (160,440 in 2004,
according to the National Cancer Institute) exceed the
number of deaths from four other major cancers combined
(breast, colon, pancreatic and prostate).
Objective: To assess the behavior and the approaches of
lung cancer in a sample of Iraqi patients.
Methods: This descriptive retrospective study was
performed using the records of 390 patients proved to have
lung cancer that had attending the Thoracic Surgery
Department of Surgical Specialties Hospital-Medical City
\Baghdad for the period from January, 1st
, 2001 to
December, 31st
,2002.
Res

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Publication Date
Sat Nov 10 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Assessment of Science Teachers' Awareness towards Communicable Diseases Control in Baghdad City Primary Schools

Objective: To assess of Science Teachers' Awareness towards Communicable Diseases Control in Baghdad City
Primary Schools
Methodology: A descriptive study was conducted, included (100) primary school, (50) in Al-Rassafa sector, and
(50) in Al-Karkh sector, from March 5th 2012 to March 15th 2013, to assess of science teachers' awareness
towards communicable diseases control. A cluster sample of (100) Science teachers (males and females) were
selected, as one teacher from each school. A questionnaire format was used for data collection. The validity of
questionnaire was estimated through a penal of experts related to the field of study, and its reliability was
estimated through a pilot study conducted in (20) schools (

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Publication Date
Sat Apr 30 2022
Journal Name
Iraqi Journal Of Science
Assessment of Liver, Thyroid Gland and Growth Hormone Functions in Beta Thalassemia Major

     Labile plasma iron and tissue iron overload are major complications of thalassemia disease that increase mortality rate. The iron that is exceeding the capacity of transferrin and ferritin is the leading cause of cell oxidation of many organs such as liver, heart, endocrine systems, etc. This study is designed to investigate the status of liver, thyroid gland and the growth hormone in beta thalassemia patients. In a cross-sectional study, 65 samples of beta thalassemia major were taken who were on a regular chelation therapy and blood transfusion and were to be compared with reference values. The results of the study estimated that 98.46% of the cases had high serum ferritin level, 12.3% high ALT, 27.7% high AST, 86.15% high ALP

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Publication Date
Sat Feb 26 2022
Journal Name
Iraqi Journal Of Science
Evaluation of PARP-1 by immunohistochemistry in a sample of Iraqi patients with gastric cancer

     PARP-1 is a protein enzyme with a major role in DNA repair that is overexpressed in many malignancies. It is correlated with susceptibility and metastasis to lymph nodes in gastric cancer (GC). The objective of the present investigation is to estimate PARP1 expression in patients with gastric cancer and detected if it could be used as a predictive marker. Furthermore, we aimed to find the correlation between PARP1 expression and clinicopathological parameters, such as gender, age, invasion depth, histopathological type, involvement of lymph nodes, grade, and stages of GC. This is a retrospective study from the period 2018-2020. Fifty randomly selected subjects (10 normal and 40 GC) were examined for formalin-fixe

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Publication Date
Thu Oct 01 2015
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Prevalence of BRCA1 Oncogen Expression in Breast Cancer Specimens of Patients with Positive Family History

Background: Breast cancer is the leading female cancer worldwide and in Iraq .Some mutations, particularly in BRCA1, significantly increase the risk of the disease.
Objectives: To demonstrate the frequency of BRCA1 in a group of high risk women with “positive family history’’ of breast cancer; correlating the immune expression of BRCA1 with some parameters of known prognostic significance.
Patients and Methods: Eighty-two female patients diagnosed with breast cancer (50 familial and 32 non familial) were included in the study .The mean age of the patients was 48.07. Immunohistochemistry was performed to assess the BRCA1 oncogene expression, Estrogen Receptor (ER), Progesterone Receptor (PR), Her 2 neu contents of the tumors.<

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