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Iraqi Breast Cancer: A Review on Patients' Demographic Characteristics and Clinico-Pathological Presentation.
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Background: Breast Cancer is the commonest type of malignancy in Iraq. The Iraqi Cancer Registry displays an obvious trend for the disease to affect younger women with advanced stages at the time of presentation. This report presents a review on the main demographic characteristics and clinicopathological parameters in Iraqi patients diagnosed with breast cancer.
Patients & Methods: The study was carried out on 721 out of a total of 5044 patients (14.3%) who complained of palpable breast lumps that were diagnosed as cancer. The procedure for tumor nuclear DNA Ploidy assessment was performed by means of Image Cytometry. Immuno-cytochemical and  histochemical assays were applied for the determination of Estrogen and Progesterone receptor (ER/PR) contents and Her-2/neu expression of the tumor tissues.
Results: Approximately one third of the breast cancer patients were diagnosed in the age period (40- 49 years), 71.9% came from urban areas and 75% were married. History of lactation and hormonal therapy was reported in 63.1% and 29% respectively, while positive family history was recorded in 16.2%. Although the lump was detected by the patient herself in 90.6%, yet only 32% sought medical advice within the first month. Accordingly 47% of these patients presented in advanced stages (III and IV).The main histological type was invasive ductal carcinoma; in which pathological changes of grade II and III were observed in 56.6% and 39.9% respectively. Cytophotometric DNA analysis showed that 80.3% of Iraqi mammary carcinomas were aneuploid. ER and PR positive tumor contents were demonstrated in 65.1% and 45.1% of the examined specimens respectively while Her- 2/neu over expression was displayed in 46.4%.
Conclusions: The aforementioned data justifies increasing efforts for establishing comprehensive breast cancer control programs in our country. Further interventional research studies using molecular biomarkers should be promoted to address the factors contributing to the illustrated aggressive tumor behavioral forms

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Publication Date
Sun May 12 2019
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Demographic and Clinical Study on Patients Referred to the National Cancer Research Center for Pap Smears
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Background: Cervical cancer ranks the fourth most common cancer among women worldwide and the eighth cancer overall. It is considered as one of the most preventable malignancies, and can be controlled through screening and Pap smears.

Objectives: To explore the demographic and clinical characteristics of a sample of Iraqi patients who were referred to the National Cancer Research Center of the University of Baghdad for Pap smear test.       

Patients and methods: The study enrolled 175 female participants who were subjected to clinical examination and Pap smear tests. A questionnaire was filled for each patient on which demographic and c

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Publication Date
Tue Jan 30 2024
Journal Name
Iraqi Journal Of Science
Clinical and Histopathological Features of Breast Cancer in Iraqi Patients between 2018-2021
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     Breast cancer (BC) is the most common malignancy in women worldwide and a major cause of cancer-related deaths for women in Iraq. This assignment was created to investigate the characteristics of BC diagnosed in Baghdad from 2018 to 2021. A total of eighty-nine of paraffin embedded tissue blocks of different breast tissue tumors (71 females and 18 males) with their data, were collected from archive of Histopathology Department, Teaching Laboratories of Medical City, Al-Yarmouk Teaching Hospital, and a private laboratory in Baghdad-Iraq. The clinical information regarding age, gender, tumor size, tumor stage and grade, lymph nodes metastasis, in addition to the findings of estrogen receptor (ER), progesterone receptor (PR), human

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Publication Date
Tue Jan 02 2018
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Breast Cancer Subtypes among Iraqi Patients: Identified By Their ER, PR and HER2 Status
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Background: Breast cancer ranks the first among the Iraqi population since three decades and is currently forming a major public health problem being the second cause of death women. Novel management of breast cancer depends upon precise evaluation of their molecular subtypes; identified by Hormone (Estrogen and Progesterone) receptors and HER2 contents of the primary tumor.
Objective: To assess the rates of the different molecular breast cancer subtypes in the examined tissue specimens belonging to females diagnosed with breast cancer in Iraq; correlating the findings with those reported in the literature at the regional and global levels.
Patients and Methods: This retrospective study documented the findings of tissue biopsy exam

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Publication Date
Tue Dec 25 2018
Journal Name
Iraqi Journal Of Science
Demographic and Clinical Study on Patients Referred to The National Cancer Research Center for Pap Smears
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A pap test is  a simple technique which  can detect pre-cancerous and cancerous cells in the vagina and cervix. Cervical cancer is the easiest gynecologic cancer we could  prevent it, with regular screening tests and follow-up this screening may avoid  cervical cancer  or detact  it early.This study aims to estimate cytological changes and precancerus lesions during Pap smear test and visual inspection of the cervix on Iraqi women and determine the relationship with demographic characteristics.   The study included 50 women aged 18-56 years (mean 39 ±10)   in  National Cancer of  Research Center (NCRC) belong to Baghdad University. These women suffered from genital problems or

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Publication Date
Mon Aug 01 2022
Journal Name
Hiv Nursing
The Influence of Some Vitamins and Biochemical Parameters on Iraqi Females’ Patients with Malignant Breast Cancer"
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The Influence of Some Vitamins and Biochemical Parameters on Iraqi Females’ Patients with Malignant Breast Cancer"

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Publication Date
Wed Dec 12 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Barriers to Baseline Needs for Early Detection of Breast Cancer among Iraqi Female Patients
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Background: Breast Cancer is the most common malignancy among the Iraqi population; the majority of cases are still diagnosed at advanced stages with poor prospects of cure. Early detection through promoting public awareness is one of the promising tools in its control. Objectives: To evaluate the baseline needs for breast cancer awareness in Iraq through exploring level of knowledge, beliefs and behavior towards the disease and highlighting barriers to screening among a sample of Iraqi women complaining of breast cancer. Methodology: Two-hundred samples were enrolled in this study; gathered from the National

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Publication Date
Wed Jan 20 2021
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Sera Level and Polymorphism of Interleukin-33 Gene in Iraqi Females Patients with Breast Cancer
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Interleukin-33 [IL-33] is a specific ligand for the ST2 receptor, and a member of the
IL-1 family. It is a dual-function protein that acts both as an extracellular alarmin cytokine,
and an as an intracellular nuclear factor participates in maintaining barrier function by
regulating gene expression of IL-33 modulating tumor growth and anti-tumor immunity in
cancer patients. The present study aimed to investigate the role of IL-33 serum level and gene
polymorphism in Iraqi women with breast cancer. Materials and methods: Blood samples
were collected from 66 Iraqi patient women diagnosed with breast cancer, which were divided
into two groups: pre-treatment [PT] and under treatment with chemotherapy [UTC] patients in

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Publication Date
Sun Oct 01 2006
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Clinical Presentation Of Reitet's Syndrome Among Iraqi Patients
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Background: To shed some light on the clinical features of patients with Reiter's syndrome.
Methods: Reiter's syndrome in 50 patients (38 males and 12 females) was reported in a prospective study. All patients were subjected to detailed history, full clinical assessment and a slit
lamp eye examination by an Ophthalmologist. A Dermatologist opinion was sought when needed and thorough laboratory and radiological investigations were made for all patients.
Results: Reiter's syndrome was post-dysnteric in 44 (88%) of patients and post-venereal in 6 (12%) patients. Its clinical features are similar to other series. Arthritis was noted in all
patients, diarrhea in 44 (88%), eye lesions in 40 (80%) and mucocutaneous le

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Publication Date
Mon Apr 01 2019
Journal Name
Biochemical And Cellular Archives
Association Of Human Cytomegalovirus With Her2 Protooncogene Overexpression In Iraqi Breast Cancer Patients
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Human cytomegalovirus (HCMV) has a worldwide distribution and common infections. The presence of HCMV genome and antigens has been detected in many kinds of human cancers. The proto-oncogene Her2/neu is overexpressed in 25% to 30% of human breast cancers and frequently associated with tumor aggressiveness and worse prognosis. Examination was applied to detect different HCMV antigens and to demonstrate their correlation with Her2/neu overexpression in breast cancer. The present study includes samples from 70 women of 60 breast cancer patients and 10 normal breast tissues. Formalin-fixed paraffin embedded tissue blocks were obtained from each woman according to ethical approval. Human cytomegalovirus early antigen expression was detected in 5

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Publication Date
Tue May 11 2021
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Pathological Nipple discharge: a comparison between breast ultrasound and mammography
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Background:Nipple discharge is a relatively common complaint of females in reproductive age and after menopause.

Objectives: The aim of this stud was to compare the radiological findings of mammography and ultrasound in women with pathological nipple discharge of different pathology.

 Methods:  mammography and ultrasound was done for a total of 50 patients attending the National center of Early detection of Breast cancer with pathological nipple discharge. Ultrasound guided FNA was performed for all cases, and histopathology was available for eleven case.

Results: ultrasound was able to provide clue of possible underlying cause for all pathological nipple discharge whereas mammography was negative in 54%

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