Background: Urany1 acetate (UA) mostly a kidney poison or chemical toxic and not nearly so much radiological also is not accumulative toxic, so it is not concentrated in the food chain nor would it cause pathological condition due to increase levels from expomers. Therefore, the study aimed to detect the target organ as most of the lethal dose (LD50) male rats died within 24 hours.
Methods: Study was done on (120) male rats of 2 months old, at varying dosage level of uranyl acetate ranging from LD 50 of 2.5 and 1.5gm/kg and varying dosage level, by oral intubation. There were (40) rats for LD 50 were given single oral dose from 2.5 to 1.5 gm /kg every day. Eighty rats for the main study, (20) rats each group as intermediate, low and high dose. After LD 50, the trail was done on groups of rats, starting as high dose as 150 mg / kg day by day then followed by intermediate dose 100 mg / kg and low dose level 75 mg / kg b.w every other day respectively with control untreated group. Duration of the study (55 day) on all rats were killed and followed by histopathological examination.
Results: The histopathological changes ranged from sever necrosis of the proximal convoluted tubules result in renal failure and that was mainly at the LD 50 and maximum level dose, rats either died after few hours or live for few days. Showing arched back and killed in poor condition, while rats treated with intermediate and low dose level showed less sever changes, mostly as dilated cortical tubules and / or cortical tubular basophilia, , only with occasional cortical tubular necrosis .
Conclusion: The Present study showed that the kidney, proximal convoluted tubules, the target for toxicological pathology of heavy metal and the main cause of death was renal failure in sever morbid cases.
Background : The dermatophytesare taxonomically related fungi causing different skin infections referred to as tineas in man or ringworm in man and animals . Objective:This study was established to investigate theof effect of yellow sap and gel of Aloe vera on skin of the rabbits which infected with T.verrucosum. Methods : Twelveskin biopsy were taken from rabbits for histopathological study to know the the effects of the T.verrucosumand treated with yellow sap and gel. Results : the results of histopathological study of effect of yellow sap and gel of Aloe vera on skin of the rabbits which infected with T.verrucosum showed the concentration of the gel of aloe vera at 75% was more effected to treat the infective area of skin with T.verrucos
... Show MoreThe ZnTe alloy was prepared as deposited thin films on the glass substrates at a thickness of 400±20 nm using vacuum evaporation technique at pressure (1 × 10-5) mbar and room temperature. Then the thin films under vacuum (2 × 10-3 mbar) were annealing at (RT,100 and 300) °C for one hour. The structural properties were studied by using X-ray diffraction and AFM, the results show that the thin films had approached the single crystalline in the direction (111) as preferred orientation of the structure zinc-blende for cubic type, with small peaks of tellurium (Te) element for all prepared thin films. The calculated crystallite size (Cs) decreased with the increase in the anne
... Show MoreWe aimed to examine the potential protective effects of Iraqi
Rats were assigned to four groups, six in each group. Group I: rats were administered a daily oral dose of 1 mL/kg/day of distilled water. Group II: rats were intraperitoneally injected with 70 mg/kg DEN once per week for 10 conse
Background: Gastric mucosal injury induced by NSAIDs is a major adverse effect of this group of medications, and it is no surprise that protection against such injury has become an important challenge for a better understanding of the mechanisms involved.
Materials and methods: This study was conducted on 40 adult male albino rats , divided into 4 groups, the first served as a control received the vehicle , the second received indomethacin orally of 60mg/kg .The third was pretreated 30 minutes prior indomethacin with omeprazole 40mg/kg orally. The fourth was given intraperitoneal L-NAME 20mg/kg plus omeprazole to investigate a possible protective role of nitric oxide. The rats were then sacrificed after 4
Background: Doxorubicin is considered one of the most effective anticancer drugs, yet it is use is limited by its side effect mediated by the generation of reactive oxygen species. Omega-7, an antioxidant has shown to have a cardioprotective effect.
Aim of the study: evaluate a possible protective effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats.
Methods: twenty-eight male rats were divided into 4 groups (7 for each group). Group 1 (Negative control): healthy animals received normal saline orally as the vehicle for eight successive days and were sacrificed on day 9. Group 2 (positive control): animals that r
... Show MoreThe problem of present study is determined by answering the following questions:
1) What is the effect of using the oral open- ended questions on Students' achievement in the third-stage of Arabic department in the college of Education? 2) What is the effect of the oral open-ended questions on developing the creative thinking of students in
... Show MoreBackground: Oral cancer is a highly lethal and disfiguring disease. Squamous cell carcinoma of the oral cavity constitutes about 90% of all oral malignancies. The aims of the study was to achieve an epidemiological description of the oral squamous cell carcinoma in Iraq in general and in Iraqi governorates except Kurdistan region retrospectively during period 2001-2013 Materials and Methods: Data were collected from department of oral and maxillofacial pathology, college of dentistry, university of Baghdad, Nuclear medicine and radiotherapy hospital, Iraqi cancer registry center, Main hospitals in Baghdad and Iraqi governorates, Private labs. for histopathological examinations. The descriptive and inferential statistical methods were used
... Show MoreBackground: Oxidative stress is a deleterious process that can be an important mediator of damage to cell structures and consequently various disease states. Exposure to free radicals from a variety of sources has led organisms to produce a series of defense mechanisms. The antioxidant ceruloplasmin is a copper-containing ferroxidase that can oxidize ferrous iron (Fe2+) to its nontoxic ferric (Fe3+) form. Ferrous iron (Fe2+) is extremely damaging because of its ability to generate toxic free radicals. Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease of unknown etiology. Previous studies reported that reactive oxygen species may be involved in the pathogenesis of lichen planus. The aim of this study was to estimate the
... Show MoreThis study examines the factors that affect oral participation of six Arab postgraduate students (two Iraqis, two Jordanians, and two Libyans), namely, three male participants and three female participants. For this purpose, a semi-structured interview was employed. The results showed that female as well male interviewees share some factors that make oral participation in classroom disheartening. These factors include high levels of anxiety, lack of confidence, shyness, and lack of preparation. It was also that there is no difference between male and female interviewees in relation to the factors that make them feel disheartened from oral classroom participation.
Background: Oral squamous cell carcinoma (OSCC) is a common malignancy characterized by poor prognosis and low survival rate. The purpose of this study was to evaluate the Immunohistochemical expressions of BAD, MDM2, and P21as apoptotic markers in oral squamous cell carcinoma. Materials and methods: This study was performed on forty formalin-fixed paraffin-embedded blocks which histopathologically diagnosed as Oral Squamous Cell Carcinoma. All cases were collected from the Histopathological Laboratory from patients treated surgically at Maxillofacial surgery Department at Ramadi Teaching Hospital, Iraq. Results: The immunohistochemical staining of BAD showed positive expression in 39 (97.5%), MDM2 showed positive expression in 39(97.5%)
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