Objective: To determine the effectiveness of hypothermia on renal functions for patients undergoing
coronary artery bypass graft CABG surgery.
Methodology: A purposive (non-probability) sample of (50) patients undergoing Isolated coronary artery
bypass graft surgery consecutively admitted to the surgical ward, and they were followed up in the
intraoperative, Intensive Care Unit (ICU) and in the postoperative (surgical ward). Post-operative renal function
test (glumeruler filteration rate (GFR) by using the Crockroft-Gault formula and serum creatinine level) was
determined first week post operative and post operative renal function was classified on the base of peak of
the serum creatinine level and decline of glomeruler filteration rate(GFR) as following : normal renal function
serum creatinine concentration and decline in(GFR) less than 25% from preoperative, moderate renal
dysfunction increase serum creatinine concentration and decline in(GFR) 25%-50% from preoperative, sever
renal dysfunction increase serum creatinine concentration and decline in(GFR) more than 50% from
preoperative test.
Results: results of this study show that (78%) from the sample develop post operative renal dysfunction and
the highly percentage of them are male (50%), advance age 60-70 (60%), smoking (47.0%), diabetes mellitus
DM (68%), cardiopulmonary bypass 180 and more (57.20%), New York Heart Association calcification NYHA
class III(47.5%) and patient without Intra Aortic Balloon Pump IABP(50,0%) . We conclude from the study that
highly percentage of patient undergoing isolated CABG may develop postoperative renal dysfunction even
when using hypothermic strategy as a protective measure and the patients with DM, male, advance age,
smoker, prolong time of CPB (more than 180 minutes), NYHA class III and patient without IABP are considered
as patient at high risk to develop postoperative renal dysfunction.
Recommendations: The researcher recommended that to find addition strategy rather than hypothermia
to protect renal function especially with the high risk patients during isolated CABG surgery.
Objectives: acute kidney injury (AKI) is a serious pathophysiology side effect of rhabdomyolysis. Inflammatory mechanisms play a role in the development of rhabdomyolysis-induced AKI. Citronellol (CT) is a naturally occurring monoterpene alcohol (3,7-Dimethyl-6-often-1-ol) found in aromatic plant species' essential oils. In this study, we explored the protective effects of Citronellol on glycerol-induced AKI.
Methods: Four groups of eight mice each (n=8) were formed by randomly dividing the animals into the groups, glycerol-induced AKI model group, low-dose CT-treated group (50mg/kg), high-dose CT-treated group (100mg/kg), and control group. The renal functions of mice from all groups were evalua
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Ethinylestradiol is widely used in oral contraceptive formulations and also for the treatment of various sexual and metabolic disorders. It is not only a genotoxic agent but also a tumor initiating agent. In the present study, the modulatory effect of aqueous extract of date pits was evaluated against the genotoxic effect induced by ethinylestradiol on human lymphocytes using chromosomal aberrations (CA), blast index (BI), mitotic index (MI), sister chromatid exchanges (SCE) and replication index (RI) as parameters. The date pits extract was evaluated at 1.075x10-4, 2.125x10-4, 3.15x10-4 and 4.17x10-4 g/ml along with 10 μM of ethinylestradiol in culture medium. The results showed a significant dose-dependent decrease in the frequency of
... Show MoreYohimbine is actually confirmed in the United States to be utilized for erectile dysfunction; and recently such drug has become commonly used in body-building communities for its presumed lipolytic and sympathomimetic effects. But ingestion of such drug can bring about epileptic neurotoxic effects.
Many antiepileptic drugs can be utilized to counteract myoclonic seizure; furthermore, diazepam can be used to oppose such type of seizure; in addition, surrogate therapeutic options such as omega 3 may also be utilized.
In this study, twenty-four (24) mice of both sexes weighing 20-25g were randomly-allocated into 4 groups (6 animals each group) as follows: Group I-
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Immune-mediated hepatitis is a severe impendence to human health, and no effective treatment is currently available. Therefore, new, safe, low-cost therapies are desperately required. Berbamine (BE), a natural substance obtained primarily from
This c
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The current study included the preparation of the aqueous extract of Raphanus sativus (Brassicaceae), commonly known as radish which is widely available throughout the world and has been used in folk medicine as a natural drug against many toxicants. The study was designed to evaluate the in vivo cytogenetic activity of the crude aqueous extract of R. sativus on mitosis on Allium cepa root tips as a plant test system. Root tips of A. cepa were tested for four hours with four concentrations of the crude aqueous extract (0.00, 5, 10, 20, 40 mg/ml). The study included a number of cytogenetic analyses such as mitotic index, phase index, and chromosomal aberration. The data s
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