Background: In type 2 diabetes mellitus there is a progressive loss of beta cell function. One new
approach yielding promising results is the use of the orally active dipeptidyl peptidase-4 (DPP-4)
inhibitors for type 2 diabetes mellitus.
Objective: This study aims at comparing the possible occurrence of macrovascular & microvascular
complications in Iraqis patients with type 2 diabetes mellitus using two combinations of drugs
metformin + glibenclamide and metformin + sitagliptin.
Methodology: Sixty eight T2DM patients and 34 normal healthy individuals as control group were
enrolled in this study and categorized in to two treatment groups. The group 1 (34 patients ) received
metformin 500 mg three times daily + glibenclamide 5 mg twice daily and the group 2 (34 patients)
received metformin 500 mg three times daily + sitagliptin 100 mg once daily. The urine sample was
collected for estimation of microalbumin urea and patients' examination was made by specialist
consultant endocrinologist.
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Results: The percentages of microalbuminurea were significantly (p<0.05) lower for group 2 patients
for 3 & 6 months of treatment (9.3%, 8.5%) respectively compared to group 1 (22.13%,18.12%)
respectively. The percentages of parasthesia, numbness and burning sensation of feet was
significantly(p<0.05) lower for group 2 patients for 3 & 6 months of treatment(16.71%,8.71%),
(20.59%,8.53) and (13.3,7.54) respectively as compared to group 1 (39.7%,34.36), (35.18,29.29)and
(37.88%,31.18%).The picture was same for postural hypotension & ischemic heart disease the
percentages were significantly (p<0.05) lower for group 2 patients for 3 & 6 months of treatment
(8.82%,7.12%)and (11.76%,8.82%) respectively as compared to group 1 (18.76%,14.65%) and
(17.65%,14.7%) respectively. The same was true for simple and proliferative retinopathy the
percentages were significantly (p<0.05) lower for group 2 patients for 3 & 6 months of treatment
(7.83%, 6.22%) and (2.82%,2.7%) respectively as compared to group 1 (15.76%,14.65%) and
(6.65%,7.71%) respectively.
Recommendations: Combination of metformin + sitagliptin significantly lower microvascular and
macrovascular complications than combination of metformin + glibenclamide.
Macrovascular and microvascular complications in type 2 diabetic Iraqi patients treated by metformin and glibenclamide versus metformin and sitagliptin
Macro vascular
Micro vascular
Diabetes
Metformin
Glibenclamide
Sitagliptin
Publication Date
Sat Dec 31 2011
Journal Name
Al-khwarizmi Engineering Journal
The Estimation of Vibrational Energy of Two Coupled (Welded) Plates Using Statistical Energy Analysis
Keywords: - Type I diabetes
Backstepping
Bergman’s model
oral glucose tolerance test.
This paper deals with a method called Statistical Energy Analysis that can be applied to the mechanical and acoustical systems like buildings, bridges and aircrafts …etc. S.E.A as a tool can be applied to the resonant systems in the circumstances of high frequency or/and complex structure». The parameters of S.E.A such as coupling loss factor, internal loss factor, modal density and input power are clarified in this work ; coupled plate sub-systems and explanations are presented for these parameters. The developed system is assumed to be resonant, conservative, linear and there is an equipartition of energy between all the resonant modes within a given frequency band in a given sub-system. The aim of th
... Show MorePublication Date
Fri Mar 01 2019
Journal Name
Applied Acoustics
Theoretical model of absorption coefficient of an inhomogeneous MPP absorber with multi-cavity depths
Micro-perforated panel (MPP) absorber has been known as an alternative absorber to classical porous material given its facile installation
long durability
environmental friendliness and attractive appearance. Extensive studies of MPP absorber proposing the improvement of its absorption frequency bandwidth have been published. This study presents a MPP absorber introduced with inhomogeneous perforations and with multi-cavity depths. The MPP is divided into two sub-area
where each area has different hole diameter
perforation ratio and a separated backed cavity depth. The acoustic impedance is modelled using electrical equivalent circuit and the absorption coefficient is calculated under normal-incidence of sound. It is found that the inhomogeneous MPP can have good bandwidth of absorption by designing the sub-MPP of smaller perforation ratio with large hole diameter and the one having the larger perforation ratio with smaller hole diameter. The absorption bandwidth can be conveniently controlled by adjusting the cavity depth of each sub-MPP. The results from the experimental work show good agreement with the theoretical model.
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