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Expression of Protamine-1 Gene and Association with Interleukin-12 gene in Infertile Men: A Case-Control Study in Iraqi Patients

     Approximately 15% of all couples all over the world suffer from difficulty conceiving their first child. The word "infertility" is used to describe this problem.

When a couple had  regular, unprotected sexual intercourse for a year or longer, it indicates that they have been unsuccessful in their efforts to conceive.

      The current investigation aims to find out if there is a relationship between PROTAMIN-1(PRM-1) and INTERLEUKINE-12 (IL-12) gene expressions and their effect on the development of infertility. The current investigation comprised 100 teratozoospermia patients and 100 healthy fertile controls who had their semen examined. Samples were given by Al-Nahrain University's Biotechnology Research Center and the Kamal Al-Samarie IVF Hospital in Baghdad, Iraq. Determinations Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR) was employed to test the expression of the PRM gene in semen and blood samples, as well as the IL-12 gene in blood samples. And the titer of IL-12 was evaluated in the seminal plasma employing the Enzyme Linked Immune Sorband Assay (ELISA) technique. The difference between the mean threshold cycle (ΔCt) of PRM-1 and IL-12 mRNA in the infertile patient group versus the healthy control group was also statistically significant. Evaluating the means of 2 ̄ΔΔCt   revealed an important finding,  a decrease in the expression of PRM-1 mRNA in the infertile group in comparison to the control group in the two types of samples. Conversely, there was an increase in the expression of IL-12 mRNA between the two study groups. In infertile Iraqi men, the expression of the PRM-1 gene was found to be down-regulated, whereas the expression of the IL-12 gene was found to be up-regulated. Our data revealed the diagnostic value of these genes and might be considered as predictive biomarkers in infertile people with idiopathic infertility. 

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Publication Date
Tue Nov 09 2021
Journal Name
Energies
Natural Convection Effect on Solidification Enhancement in a Multi-Tube Latent Heat Storage System: Effect of Tubes’ Arrangement

The solidification process in a multi-tube latent heat energy system is affected by the natural convection and the arrangement of heat exchanger tubes, which changes the buoyancy effect as well. In the current work, the effect of the arrangement of the tubes in a multi-tube heat exchanger was examined during the solidification process with the focus on the natural convection effects inside the phase change material (PCM). The behavior of the system was numerically analyzed using liquid fraction and energy released, as well as temperature, velocity and streamline profiles for different studied cases. The arrangement of the tubes, considering seven pipes in the symmetrical condition, are assumed at different positions in the system, i

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Publication Date
Thu Apr 20 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
A Protective effect of (Andrographis Paniculata) on 4-Vinylcyclohexene Diepoxide Induced ovarian Toxicity in Female Albino Rats: introduction

Abstract

Background and objective: Protective effect of (Andrographis Paniculata) on 4-Vinylcyclohexene Diepoxide.

Material and methods:A group of 55 female albino rats undergo experiment on the outcome effect of 4-vinylcyclohexene Diepoxide injection for a priod of two weeks, as well as treatment effect of methanolic leaf extract of Andrographis paniculata oral administration for four weeks. Injection  concentrations (160 and 320mg/kg. B.W) also two different doses of treatment (100 and 200mg/kg. B.W) have been applied.

Results:The results on body weight and ovary weight were more evident when higher concentration dose was applied.

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Publication Date
Wed Nov 20 2024
Journal Name
Al–bahith Al–a'alami
The Role of Public Relations in Observing Media Publishing During International Conferences: (Arab Summit 2012 as a Model)

 

This study aims to identify the issue of observing media publishing and its importance for public relations in the management of special events; and its role in building the positive image of the target audience through communication messages that illustrate the political, economic and diplomatic importance of the Arab Summit. As such Summit is one of the conferences that Iraq sought to secure the requirements of its convening to re-activate its political and diplomatic role in the Arab Ocean, especially after the circumstances and crises that Iraq went through.

The convening of the Arab Summit under the auspices of Iraq was a qualitative transition, during which Iraq sought to achieve some gains b

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Publication Date
Fri Jan 01 2021
Journal Name
Microchemical Journal
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Publication Date
Wed Dec 25 2019
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
Peaceful settlement as a means of preventing tax: An applied research in the General Commission for Taxation evasion

The reconciliation of tax reconciliation is one of the legal methods used by the financial authority in Iraq, which is done with the taxpayer

The research dealt with the weakness of tax revenues for many reasons, including tax evasion, which led to the search for ways to reduce evasion to increase the tax revenue, and settlement reconciliation one of these means .

The research proceeded from the premise that the use of a more broadly settled settlement would govern the tax evasion of taxpayers.

The researchers used a series of studies and previous research, books and other sources related to the subject of research, and this was done through the theoretical framework, and the practical aspect that included the fin

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Publication Date
Wed Mar 20 2019
Journal Name
Journal Of Legal Sciences
Uniform Code Strategy for Professional Companies in the framework of the Company's Simple Rules - Iraq as a Model

The huge competition in the field of services' provision and the strong motive for survival, continuity and evolution requires the search for effective methods by which the professionals can meet within legal frameworks that achieve effective guarantees in order to provide services to the public that based on the knowledge and efficiency of the company members, such as law firms, engineering and accounting consultants.

The professional may confront with a number of practical difficulties when starting a specific professional activity individually, which would require concerted efforts and teamwork within the framework of an organization known as the professional company.

Thus, the practice of the professional activity in

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Publication Date
Mon Mar 15 2021
Journal Name
Al-academy
Aesthetics of the Artistic Construction in Educational TV Programs " progrm Hello Hi! A Model": محمد عبد الرضا حسين

  The TV has the ability to combine sound and picture, which makes it of a direct impact on the recipient as it is a rich communicative tool with various artistic forms that display through this small screen programs and films, so that the TV has become superior over many other means of communication.
This research is concerned with the technical and artistic ability in the production of programs owned by the TV as a means of attraction of educated children aged between 5-12 years old, which makes it an educational supplement for the school that helps them in providing knowledge, acquiring skills and being informed about the different sciences through educational programs. It is known that the child at this stage enjoys when wa

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Publication Date
Sat Apr 30 2022
Journal Name
Iraqi Journal Of Science
Fabrication of Vertical Axis Wind Turbine (VAWT) for a Water Pump at Low Speed Wind in Tikrit Region

      We have designed, fabricated and studied the vertical axis wind turbine and its characterization. The system has been locally designed to pump water. It is considered as a one of the best options for low speed wind. The turbine has eight blades , each blade is 1.8m in length,  and the area dimension of the turbine 3.6 m2 . were investigated  the  best characterization of the system at low wind speed are Power turbine  depends on the wind speed. It was 280 Watt at 6m/s and 160 watt at 5m/s  , and  the power after the turbine decreasing to factor  1/3. The system torque was 20 N.m , Power coefficient cap  0.29 , Tip speed ratio 0.46. It is suitable to be used in Iraq region , and low cost for get the wat

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Publication Date
Thu May 14 2020
Journal Name
Journal Of Planner And Development
“The role of parametric approach in design highest climatic performance buildings: local housing design patterns as a sample”

In light of increasing demand for energy consumption due to life complexity and its requirements, which reflected on architecture in type and size, Environmental challenges have emerged in the need to reduce emissions and power consumption within the construction sector. Which urged designers to improve the environmental performance of buildings by adopting new design approaches, Invest digital technology to facilitate design decision-making, in short time, effort and cost. Which doesn’t stop at the limits of acceptable efficiency, but extends to the level of (the highest performance), which doesn’t provide by traditional approaches that adopted by researchers and local institutions in their studies and architectural practices, limit

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Publication Date
Sun Apr 01 2018
Journal Name
Journal Of Educational And Psychological Researches
The obstacles that encounter a program of rehabilitating released prisoners as perceived by prisoners themselves in tubas' province

The study intends to explore the obstacles that encounter a program of rehabilitating released prisoners as perceived by prisoners themselves in tubas' province. To this end, the researcher used a questionnaire as an instrument which was applied on (150) prisoner had chosen randomly to collect the study data. The findings revealed no significant differences among obstacles the encounter program regarding to the following variables: age, detention period, and number of detention, additionally, the findings found that there is a variance of obstacles mean according to the prisoners themselves, rehabilitation program, and the facility of that program.

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