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Effect of Silver Nanoparticles Synthesized by Pulsed Laser Ablation in Liquid on the Hematological, Hepatic, and Renal Functions of Albino Rats

     Silver nanoparticles (Ag-NPs) have unique properties as antibacterial effects against locally isolated clinical Escherichia coli.  In this study, the evaluated the antibacterial activity of AgNPs, which were synthesized by laser ablation, against locally isolated clinical  Escherichia coli on nutrient agar media in vitro. Then assessed the toxicity of the bactericidal dose in albino rats in vivo with hematological, liver, and kidney functions as vital parameters. AgNPs were synthesized by pulsed laser ablation in liquid (PLAL).  AgNPs’ shape and nano size were characterized by atomic force microscopy (AFM), UV-vis spectroscopy, and scanning electron microscopy (SEM). UV peak absorption was observed at 434 nm, which produced an average particle diameter of 28.09 nm. The SEM and AFM topography images of the synthesized nanoparticles showed that they had a spherical shape. Also studied was the toxicity of the synthesized AgNPs in vivo. Four groups of albino rats were used. The liver and kidneys were found to be the main organs that accumulate AgNP. In this study, we examined the influence of intraperitoneally injected AgNPs on blood parameters (complete blood picture) and liver and kidney functions of albino rats. Blood ALP and serum test (GOT and GPT), serum urea and serum creatinine were analyzed at 15, 30, and 60 days after injection of 200 mg/kg of PLAL-synthesized AgNP. The results did not indicate statistically significant differences between the control and treatment groups in blood picture and enzyme levels tested that indicate proper liver function. Additionally, no differences in kidney functions were found during varying time intervals in the blood of rats. Thus, PLAL-synthesized AgNPs could inhibit Escherichia coli bacterial growth.

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Publication Date
Thu Jun 15 2023
Journal Name
Journal Of Baghdad College Of Dentistry
Antibacterial and cytotoxic effect of a novel bio-logical Nano-silver fluoride synthesized from moringa oleifera leaf extract

Background: A great dental and biomedical interest had been paid to silver nanoparticles because of their antimicrobial activity. Objective: To evaluate the antimicrobial and cytotoxic activity of a newly developed Nano-silver fluoride that was synthesized from moringa oleifera leaf extract against S. mutants.  Material and method: The green synthesis method was used to prepare Nano-silver fluoride from moringa oleifera leaf extract. The minimum inhibitory concentration and the minimum bactericidal concentration were evaluated using brain heart infusion plates, while the cytotoxicity was evaluated by the hemolytic activity. Results: Nano-silver fluoride had a bactericidal and bacteriostatic effect (MIC was 60 ppm a

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Publication Date
Sun Dec 19 2021
Journal Name
Iraqi Journal Of Science
Biological effects of different doses of Piroxicam in albino males rats

Current study aimed to investigate the effect of piroxicam on some hematological
and biochemcal parameters. For this reason forty males mature Sprage Dawlley rats
were divided into four equal groups. control group administrated distilled water
(G1), and three groups administrated (20mg/kg,30mg/kg,40mg/kg) body weight of
piroxicam for 45 days. The results showed significant decrease (P<0.05) in
hemoglobin (Hb) and packed ceq volume (PCV) in groups treated with
(30,40)mg/kg of piroxicam, while the treated groups produced significant increease
(P<0.05) in the total white blood cell count (WBC). On the serum biochemical
porameters, Piroxicam caused increase in the level of liver enzyme amunotans ferase
(ALT)

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Publication Date
Sat Jan 01 2022
Journal Name
Annals Of Biology
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Publication Date
Wed Mar 30 2022
Journal Name
Iraqi Journal Of Science
Effect of the Pulsed Laser Energy on the Properties of CdO: NiO Composite Thin Films for Solar Cell Applications

     In this work, thin films of cadmium oxide: nickel oxide (CdO: NiO) were prepared by pulsed laser deposition at different pulse energies of Nd: YAG laser. The thin films' properties were determined by various techniques to study the effect of pulse laser energy on thin films' properties. X-ray diffraction measurements showed a mixture of both phases. The degree of crystallinity and the lattice constant increase with the laser energy increase, while the lattice strain decreases. FE-SEM images show that the substrates' entire surface is uniformly covered, without any cracks, with a well-connected structure consisting of small spherical particles ranging in size from 15 to 120 nm. Increasing the laser power causes to increase the pa

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Publication Date
Wed Jun 30 2010
Journal Name
Al-kindy College Medical Journal
The Influences of Aminophylline and Indomethacin in Glycerol-Induced Acute Renal Failure in Rats

Background: Adenosine mediates homodynamic
changes and resulted in the production of acute renal
failure (ARF) in female Albino-Wister rats, therefore,
adenosine level increases highly in ARF.
Objective: This experiment was designed to
investigate the effect of the adenosine antagonist
aminophylline and the adenosine agonist indomethacin on glycerol-induced ARF.
Method: Glycerol induced ARF was produced by a
single dose (10ml/kg, 50%v/v with distilled water i.m)
in rats, which were restricted to drinking water.
Aminophylline was used in our study in a dose of
25mg/kg, i.p) while the dose of indomethacin was
10mg/kg, i.p), assessment of renal function was done
by measuring blood urea
nitrogen (BUN

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Publication Date
Wed Dec 01 2021
Journal Name
Baghdad Science Journal
Enhancement of Electron Temperature under Dense Homogenous Plasma by Pulsed Laser Beam

The applications of hot plasma are many and numerous applications require high values of the temperature of the electrons within the plasma region. Improving electron temperature values is one of the important processes for using this specification in plasma for being adopted in several modern applications such as nuclear fusion, plating operations and in industrial applications. In this work, theoretical computations were performed to enhance electron temperature under dense homogeneous plasma. The effect of   power and duration time of pulsed Nd:YAG laser   was studied on the heating of   plasmas  by inverse bremsstrahlung  for  several values for the electron density ratio. There results for these ca

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Publication Date
Tue Jan 01 2019
Journal Name
Energy Procedia
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Publication Date
Fri Dec 29 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The Effect of Jaundice on Some Hematological and Biochemical Parameteres in Human

This   study   has   investigated   the   effect   of   jaundice   on   some

hematological  and biochemical paramenters in male and female.  The results have shown significant decrease in Hemoglobin concentration, packed cell volume, white blood cell count and platelet count. The biochemical parameters results have shown significant increase in prothrombine time, level of total bilirubin, Aspartale transminase and Alanin trans aminase in the serum of male and femal.

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Publication Date
Fri Sep 09 2022
Journal Name
Journal Of Ovonic Research
The effects of CuO doping on structural, electrical and optical properties of CdO thin films deposited by pulsed laser deposition technique

Thin films of (CdO)x (CuO)1-x (where x = 0.0, 0.2, 0.3, 0.4 and 0.5) were prepared by the pulsed laser deposition. The CuO addition caused an increase in diffraction peaks intensity at (111) and a decrease in diffraction peaks intensity at (200). As CuO content increases, the band gap increases to a maximum of 3.51 eV, maximum resistivity of 8.251x 104 Ω.cm with mobility of 199.5 cm2 / V.s, when x= 0.5. The results show that the conductivity is ntype when x value was changed in the range (0 to 0.4) but further addition of CuO converted the samples to p-type.

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Publication Date
Sun Jul 02 2006
Journal Name
Journal Of The Faculty Of Medicine Baghdad
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