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Effect of s-Klotho Protein, GPX, Visfatin, Leptin and ROS of Iraqi Women with Breast Cancer
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     The most prevalent cancer is breast cancer, and the incidence of breast cancer in women worldwide is increasing at a remarkably rapid rate. This study was conducted on 90 samples (45 newly diagnosed breast cancer samples and 45 control group samples), ranging in age from 35 to 70 years. Blood samples were collected from the Alawia Teaching Hospital and the Oncology Teaching Hospital between October 2020 and March 2021. ELISA assessed ROS, GPX, visfatin, IGF-1, vitamin A, leptin, and soluble al-Klotho. The results indicate that the breast cancer patients had significantly higher (ROS 3.57, visfatin 17.44) (ng/mL) (p<0.0001) and leptin 16.11 (ng/mL). In the group of patients, there was a significant increase (p<0.004) compared with the control group, whereas there were no significant differences between IGF-1 (624.72 pg/mL) (p>0.507), s-Klotho 398.22 ng/L (p>0.653), and vitamin A 69.49 umol/L (p<0.05). The results showed a negative correlation among the levels of patients with BC (ROS and vitamin A, GPX, IGF-1, GPX, leptin, and vitamin A). Finally, the current study concludes that vitamin A deficiency is one of the important factors that may influence the clinical evolution and prognosis of patients with breast cancer. Moreover, it was shown that the higher levels of leptin and visfatin could increase the danger in BC cases. The study measured levels of leptin and visfatin, which can increase the danger in BC cases, and measured ROS in patients.

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Publication Date
Sat Dec 31 2022
Journal Name
Al-kindy College Medical Journal
Assessment of Serum Level of Protein Carbonyl as a Marker of Protein Oxidation in Patients with Type 2 Diabetes Mellitus
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Background: Diabetes mellitus is a chronic disease with an increasing prevalence worldwide and characterized by an increase in oxidative stress and inflammation. The most important factor that is responsible for oxidative stress and production of reactive oxygen species (ROS) is hyperglycemia. The major targets of ROS are proteins. The most common and widely used biomarker of severe oxidative protein damage is protein carbonyl content.

The study was designed to assess the serum level of protein carbonyl as a marker of protein oxidation in patients with type 2 diabetes mellitus and to evaluate the effect of age, body weight, waist circumference, diabetic control and disease duration on the level

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Publication Date
Thu Dec 01 2016
Journal Name
Karbala Journal Of Medicine
Assessment Of Her-2/Neu Gene Amplification Status by Chromogenic in Situ Hybridization in Breast Cancer Patients with Equivocal 2+ Her-2/Neu Immunostaining and Its Relation to The Clinic Pathological Parameters
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background: human epidermal growth factor receptor-2 (her2/neu) is related to growth factor receptors with alkaline kinase activity and it is regarded as important prognostic and therapeutic factor that can depended on in breast cancer therapy. HER2/neu expression by immunohistochemistry (IHC) is submitted to a great in terob server inconsistency. Subsequently additional confirmatory tests for assessment of gene alterations and amplification status are needed for patients with early or metastatic breast cancer. In situ hybridization techniques and specifically Chromogenic in situ hybridization (CISH) was arise as a practical, cost-effective, and alternative to fluorescent in situ hybridization in testing for gene alterationAims of the study

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Publication Date
Thu Dec 01 2022
Journal Name
Baghdad Science Journal
Studying the genotype of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) Gene (rs641081C>A) in ‎Iraqi Samples with Acromegaly Pituitary Adenoma
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Pituitary adenomas are the anterior pituitary tumors. Patients with an Aryl Hydrocarbon Receptor-Interacting Protein (AIP) mutation (AIP- mut) tend to have more aggressive tumors occurring at a younger age. Single nucleotide polymorphisms (SNPs) in many studies have been related to metabolic comorbidities in the general population. Study aims investigated the role of AIP gene SNPs with susceptibility to acromegaly pituitary- adenoma, with levels of LH, FSH, TSH, Testosterone, IGF1,GH, FT4 , Prolactin hormones and blood sugar levels.  The study ‎was conducted on a group of acromegaly patients, including 50 patients) both Genders( with ‎hyperplasia of the ends, and apparently healthy control group. Genotyping of

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Publication Date
Thu Sep 01 2022
Journal Name
Precision Radiation Oncology
Assessment of dose‐volume histogram statistics using three‐dimensional conformal techniques in breast cancer adjuvant radiotherapy treatment
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Abstract<sec><title>Objective

Breast cancer (BC) is first of the top 10 malignancies in Iraq. Dose‐volume histograms (DVHs) are most commonly used as a plan evaluation tool. This study aimed to assess DVH statistics using three‐dimensional conformal radiotherapies in BC in an adjuvant setting.

Methods

A retrospective study of 70 histologically confirmed women diagnosed with BC was reviewed. The study was conducted between November 2020 and May 2021, planning for treatment with adjuvant three‐dimensional conformal radiotherapies. The treatment plan used for each woman was based on an analysis of the volumetric dose, inclu

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Publication Date
Thu Feb 10 2022
Journal Name
Iraqi Journal Of Science
Quantitative study of some trace elements and blood parameters in the third trimester of Iraqi pregnant women with Pre-eclampsia
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Pre-eclampsia complicates 2-8% of all pregnancies and it is one of the leading causes of maternal mortality and pre-term delivery in the world. Unfortunately, there is scarcity of documents discussing the circulating level of several essential trace elements in Pre-eclampsia patients in Baghdad especially in the last trimester of the pregnancy. The present study was designed to quantitative evaluation the whole blood concentration of two trace elements, copper (Cu), and iron(Fe), in pre-eclamptic women in the third trimester of pregnancy. The study was conducted on 18 Pre-eclamptic pregnant women as patients group with clinical detected high blood pressure ≥140/90 mmHg and 13 normotensive pregnant women as control group from Al-Alwiya

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Publication Date
Thu Nov 02 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Total Protein and Total Fucose in Sera of Patients with Thyroid Dysfunction and Control
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Total protein and total fucose were determined in sera of thyroid

disorder patients.

Sera of (40) diagnosed by consultant hyperthyroidism, and 40 hypothyroidism  were analyzed  for  the above  parameter  for  control, sera of (40) normal individuals were used.

They   were   healthy   with    no  appearing   disorder   results   analysis revealed  no significant  differences  (P<0.05)  in  the (mean  Â±SD)  of total   protein   values  in   sera  of   hyper  and   hypothyroidism   were compared

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Publication Date
Sun Jul 01 2007
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Preoperative and Postoperative Serum Immunoglobulins Levels in Colorectal Cancer of Iraqi Patients
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Background: Quantitation of serum immunoglobulins (IgG, IgA and IgM) provides useful information for the evaluation of certain cancers.
Objectives:to estimate serum immunoglobulins level before and after surgery, and to shed light on the correlation of immunoglobulins with progression of CRC.
Patients and Methodes. By single radial immune diffusion method IgG, IgA, IgM were estimated in 100 CRC patients preoperatively, and in 20 patients postoperatively compared with 35
patients control with ulcerative colitis (UC) and 50 healthy control.
Results: The study showed significantly increased the serum IgM level in patients group preoperatively (p<0.001) compared with control group. On the other hand, no sig

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Publication Date
Wed Mar 30 2022
Journal Name
Iraqi Journal Of Science
s-Compressible and s-Prime Modules
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   Let R be a ring with identity and Ą a left R-module. In this article, we introduce new generalizations of compressible and prime modules, namely s-compressible module and s-prime module. An R-module A is s-compressible if for any nonzero submodule B of A there exists a small f in HomR(A, B). An R-module A is s-prime if for any submodule B of A, annR (B) A is small in A. These concepts and related concepts are studied in as well as  many results consist properties and characterizations are obtained.  

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Publication Date
Wed Nov 07 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Study of some risk factors and C - reactive protein levels among patients with cardiovascular diseases
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Objective : To study the effect of some risk factors like age, smoking and Diabetes mellitus (DM) among patients with
certain cardiovascular diseases (Angina pectoris and Myocardial infarction), in addition to the assessment of the Creactive
protein (CRP) in the sera of those patients.
Methodology: The study was carried out on (100) subjects who were hospitalized in the Iraqi Center of heart Diseases
in Baghdad city and were suffering from Myocardial InfarcƟon (MI) (16) and Angina Pectoris (AP) (79) or from both (5)
over a period from September 2009 to June 2010. The results of paƟents were compared with those of (30) healthy
and age-matched individuals as a control group. Data were obtained from patients who were alr

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Publication Date
Mon Jan 01 2024
Journal Name
Oncology And Radiotherapy
Comparting study of cytokeratin 18 fragment M65 with CA19-9 and CEA as a biomarker in Iraqi colon cancer patients
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