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Exploring the Role of Caspase-3 and IL32 in SARS-CoV-2 Infection among Iraqi Patients
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     Understanding Caspase-3 (CASP-3) and interleukin-32 (IL32) roles in SARS-CoV-2 infection is critical to linearize the pathogenesis of the virus as well as the resultant disease which may uncover novel therapeutic targets in treating COVID-19 patients. This study aimed to evaluate caspase‐3 (CASP3) and interleukin 32 (IL32) roles and their correlation with the disease severity among patients.  The case-control study (140 patients and 60 healthy controls) was performed with molecular and ELISA assays. CASP3 and IL32 serum levels were determined along with other clinical data of patients. CASP3 levels were classified as significantly higher (p < 0.001), while IL-32 levels were significantly lower in production (p < 0.001) in most critical and severe patients compared with mild-moderate. Additionally, IL 32 production reduced with older age, whereas CASP3 levels elevated with older age compared to younger years. Also, the IL-32 showed a protective factor from the severity of the SARS-CoV-2 progression as a negative correlation with the biomarkers (lactate dehydrogenase (LDH), ferritin and D. dimer) values. Thus, IL-32 appeared as the opposite effect of the CASP3 on the severity of COVID-19 infections. ROC curve analysis indicated that IL32 is a good predictor in providing information about the severity of the disease and host recovery. Whereas CASP3 is associated with progressive disease (cut-off value = 160.7 pg/mL; 5.64 ng/mL respectively). CASP3 and IL32 can possibly provide information about the COVID-19 and could be used as cytokine markers to detect SARS-CoV2 infection severity and determine the most reliable treatment plan. More research is needed on this subject.

Keywords: Autoimmune disease; Hematological disorder; Renal failure; Inflammatory markers.

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Publication Date
Tue Jul 31 2018
Journal Name
Online Journal Of Veterinary Research
Clinical pathology and immuno-histochemistry of mammary tumors from military and pet dogs in Iraq.
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Mammary tumors (CMT) in dogs in Iraq may be induced by carcinogenic war ordnance. In our study, 10 virgin un- spayed military/pet bitches aged 5-15 years presented with abnormal masses in the abdomen with painful oedema, swelling, anorexia, weight loss, weakness and mild fever. Examination of regional lymph nodes and thoracic radiography confirmed metastasis. Tumors were excised and determined to be mostly adenocarcinomas involving multiple glands, solid in texture, 5-15 cm in size, mostly in the inguinal mammary glands at stage T3: >5 cm. Microscopy confirmed presence of adenocarcinoma in 8 dogs and solid carcinoma in 2 with half of tumors being grade III. Tumors had pleomorphic hyperchromatic cell nuclei in stroma, epithelial cells of duc

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Publication Date
Fri Oct 20 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Detection of Lead (Pb) and Cadmium (Cd) Concentrations and Hazards in Some Baby Food Samples
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This study was conducted to detect the concentration of lead and cadmium in baby foods, (18) samples were examined, which are the most available from various local markets in the city of Baghdad (at a rate of (9) samples of baby food consisting of cereals and (9) samples of baby foods consisting of vegetables). All samples were examined using an atomic flame absorptiometry (AAS-7000), all results showed the presence of lead and cadmium and the highest concentration value of lead in baby foods consisting of cereals (1.0986) and cadmium in baby foods consisting of vegetables (0.0015) ppm. Lead exceeded 100% limitations and cadmium did not exceed that. The results reported on the risks of contamination, as the mean daily intake (g/kg/d) for

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Publication Date
Wed Jan 01 2020
Journal Name
Methods And Objects Of Chemical Analysis
Derivative Spectrophotometric Determination For Simultaneous Estimation Of Isoniazid And Ciprofloxacin In Mixture And Pharmaceutical Formulation
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A simple analytical method was used in the present work for the simultaneous quantification of Ciprofloxacin and Isoniazid in pharmaceutical preparations. UV-Visible spectrophotometry has been applied to quantify these compounds in pure and mixture solutions using the first-order derivative method. The method depends on the first derivative spectrophotometry using zero-cross, peak to baseline, peak to peak and peak area measurements. Good linearity was shown in the concentration range of 2 to 24 μg∙mL-1 for Ciprofloxacin and 2 to 22 μg∙mL-1 for Isoniazid in the mixture, and the correlation coefficients were 0.9990 and 0.9989 respectively using peak area mode. The limits of detection (LOD) and limits of quantification (LOQ) wer

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Publication Date
Sun Apr 30 2023
Journal Name
Iraqi Journal Of Science
Batch and Flow Injection Spectrophotometric Determination of Tetracycline Hydrochloride and Doxycycline Hyclate in Pharmaceutical Preparations
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New, simple and accurate batch and flow injection spectrophotometric
methods have been developed for the determinationsof tetracycline
hydrochloride (TCH) and doxycycline hyclate (DCH) in pharmaceutical
preparations. The methods are based on diazotization of
metchlopramide and coupling reaction with either TCH or DCH in alkaline
medium to form yellow–orange water soluble dye with absorption maxima
at 414 and 436 nm for TCH and DCH, respectively. A graphs of absorbance
versus concentration show that Beer’s law was obeyed over the
concentration ranges of 1 –52 μgmL-1 TCH and DCH for batch method and
of 8 – 240 μg mL-1 TCH and 5 – 350 μgmL-1 DCH for FIA method. The
limits of detection in batchmetho

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Publication Date
Wed Jun 29 2022
Journal Name
Egyptian Journal Of Chemistry
First- and Second-Derivative Spectrophotometry for Simultaneous Determination of lorazepam and clonazepam in pharmaceutical formulations.
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Publication Date
Thu May 25 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Lipid Peroxidation, Prooxidant and Related Antioxidant Proteins in Various Types of Hyperlipoproteinemic Males and Control
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Thirty nine hyperlipoproteinemic (HPLic) male subject aged (48-63) year not on any of the lipid lowering drugs, attending out patient clinic at Baghdad Teaching Hospital, were included in the present study, in addition to twenty two normolipidimic male subjects of matched age were included as control throughout this study. The first part of this study was devoted to the classification of the HPLic subjects according to the serum lipid and lipoprotein profile following defined criteria. The lipid parameter including total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) were investigated in serum of HPLic subjects included in the study. The classification was performed according to Fred

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Publication Date
Wed Mar 01 2023
Journal Name
Egyptian Journal Of Chemistry
First- and Second-Derivative Spectrophotometry for Simultaneous Determination of lorazepam and clonazepam in pharmaceutical formulations
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The present study describes employing zero-, 1st - and 2nd -order derivative spectrophotometric methods have been developed for determination of lorazepam (LORA) and clonazepam (CLON) in commercially available tablets. LORA was determined by means of 1st (D1), 2nd (D2) derivative spectrophotometric techniques using zero cross, peak height, and Peak area. D1 used for the determination of CLON by using zero cross and peak height while D2 (zero cross) was used for the determination of CLON. The method was established to be linear in concentration containing different ratios of LORA and CLON range of (20-200 mg/L) and (5-35 mg/L) at wavelength range (250 -370 nm), (210-370nm) respectively. The proposed techniques are highly sensitive, precise a

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Publication Date
Thu Apr 28 2022
Journal Name
Iraqi Journal Of Science
Microscopic calculations of effective charges and quadrupole transition rates in Si, S and Ar isotopes.
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Quadrupole transition rates and effective charges are calculated for even-even Si,
S and Ar isotopes based on sd and sdpf -shell model spaces. Shell model
calculations are performed with sd shell-model space for neutron number (N) ≤ 20
and sdpf shell-model space for N > 20. Excitation out of major shell space are taken
into account through a microscopic theory which allows particle-hole excitation
from the core and model space orbits to all higher orbits with 2 excitation.
Effective charges are obtained for each isotope. The results show a systematic
increase in the B(E2) values for N 20. Shell model calculation predicts the erosion
of the N=28 magicity in the neutron rich 42Si. No clear indications abo

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Publication Date
Wed Aug 30 2023
Journal Name
Iraqi Journal Of Science
Distribution and Evaluation of Lead and Cadmium in Some Soils Surrounding East Baghdad Oil Field
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     Soil acts as a last sink for elements that people release into the environment through a range of activities due to its physiochemical characteristics. These substances, whether are organic or mineral pollutants, accumulate in the soil and constitute a significant risk to the ecosystem in general because they mess with the chemical and physical equilibrium of the soil, get into the food chain, and eventually get to people. When pollutant concentrations during the bioaccumulated process exceed the global standards for what is regarded as a contaminant in water, air, and soil. Nine soil samples were collected from different sites and two samples from each site at two depths (0-20 and 20-40 cm) to determine if there were any

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Publication Date
Fri Nov 29 2024
Journal Name
Chemical Engineering Research And Design
Comprehensive review of severe slugging phenomena and innovative mitigation techniques in oil and gas systems
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