Ten new thiourea derivatives 1-10 were prepared in this work using a two-step process that involved reacting 4-methoxybenzoyl chloride with KSCN to afford 4-methoxybenzoyl isothiocyanate. This was followed by reaction with various amines (primary amines, secondary amines, and diamines) to give the aforementioned title products 1-10. These products were characterized by FT-IR, 1H NMR and 13C NMR spectroscopy. Using the DPPH scavenging method, the antioxidant activity of thiourea products was investigated, and derivative 8 had the greatest antioxidant activity in comparison to the other derivatives. Moreover, molecular docking for all compounds was studied using Autodock (4.2.6) software and Bacillus pasteurii urease (pdb id: 4ubp) as a target protein. The best inhibitor activity and docking scores are displayed by compound 7, followed by compounds 5 and 6, which highlight the importance of compounds having two thiourea moieties for higher inhibition activity.
In the present work, a series of new bis cyclic imides (pyromellit imides) linked to different nitrogen heterocycles namely (pyridine, pyrimidine, phenazone and quinoline) was synthesized.
Synthesis of the new imides was performed via two steps in the first one a series of bis amic acids (pyromellit amic acids) was synthesized via reaction of pyromellitic anhydride with variety of nitrogen heterocyclic primary amines while in the second step the prepared bis amic acids were dehydrated via treatment with acetic anhydride and anhydrous sodium acetate affording the desired imides.
The prepared bis Imides were screened for their antimicrobial activity against many types of bacteria and fungi and the results indicated that they possess
This study consists of two parts, field and experimental. In field part; cadmium concentrations were measured in soil and parsley Petroselinum crispum samples of five different agricultural areas in Baghdad city. These areas were located in Al-Rashdiah, Tounis quarter, Al-Shamasiah quarter, Al-Itaifiah and Al-Twaithah. Soil cadmium concentrations were (1.72, 1.25, 1.52, 3.45 and 3.33) mg/kg in Al- Rashdiya, Tunis quarter, Al- Shamasiya quarter, Al- Attaifiya and Al-Tuaithah respectively, while concentrations in parsley were (0.28, 0.26, 0.28, 0.39 and 0.38) mg/kg respectively. Experimentally, five groups of albino mice males (10 mice each) were administered with different concentrations of cadmium (0.0, 0.25, 0.5, 0.75 and 7.5) mg Cd/kg
... Show MoreIn the present study, a novel ligand (L) made of 2-hydroxynaphthaldehyde and 3-hydrazone-1,3-dihydro-indole-2-one(3-[(3-hydroxynaphthalen-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one). The ligand was characterized by FTIR, UV-vis, mass, 1H-NMR, 13C-NMR, and CHN elemental analysis. New complexes of this ligand were created by treating methanol and a drop of DMF solution of the produced ligand with the hydrated metal salts of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) in a molar ratio of 2:1 (L:M). As a result, complexes have been emerged and identified FTIR, UV-vis, C.H.N., chloride-containing, molar conductance, magnetic susceptibility, and atomic absorption. The characterization result for each complex indicated complexes wi
... Show MoreThe dispersion of supported Pt and Pt–Ir reforming catalysts have been studied, after treatment with oxidative and reducing atmosphere. Methylcyclohexane dehydrogenation reaction in the absence of hydrogen was used as a test reaction. An attempt was made to relate the behavior of the catalysts upon subject to reaction, to the dispersion of the same type of catalysts upon treatment with similar atmosphere and temperatures which appeared in literature. The total conversion of reaction can be explained by a change in metal dispersion. Thus, methylcyclohexane dehydrogenation reaction appears to be a really “structure sensitive” reaction.
The toluene yield increases as the oxidation temperature i
... Show MoreThis research involves the preparation of new ligands 1,1,2,2- tetrakis (sodium acetate thio)ethylene(L1) and 1,1,2- tris(sodiumacetatethio) ethylene(L2), through the reaction of disodium thioglycolate) with tetra chloro ethylene or tri chloro ethylene in (1:4) or (1:3) moler ratio . Homodinucliar complexes of general formlu [M2(L1)] and [M2(L2)ClH2O] , when M= Co(II), Ni(II), Cu (II) and Zn(II) also mono nuclear complexes of general formula [M(L2)] . The prepared complexes were characterized using spectral method (UV/Visible/ IR) , metal content analysis , magnetic and atomic measurements . The spectral and magnetic measurement indicats that some complexes have tetrahedral or square planar complexes environtment .
Complexes of Au (III), Pd (II), Pt (IV ) and Rh(III) with S–propynyle-2- thiobenzimidazole (BENZA) have been prepared and characterized by IR and UV- Visible spectral methods in addition to magnetic and conductivity measurements and micro–elemental analysis (CHN).The probable structures of the new complexes have been suggested.
In Baghdad governorate, samples of dried birds waste were obtained from poultry cages for investigate the of the presence of fungi. There was a high proportion of Candida spp., Rhodotorula spp. and filamentous fungi that obtained from the dry droppings. Al samples gave a positive results included 177 isolates, these isolates includes different Candida species 62 isolates (35.02%), Rhodotorula spp. 28 isolates (15.81%), and the following filamentous genera: Aspergillus spp. 50 isolates (28. 24%), (A. niger 20 isolate, A. flavus 18 isolate, A. fumigatus 12 isolate), Penicillium spp. 11 isolates (6.21%) and Mucor spp. 26 isolate (14.68%). The inhibitory effect of the used detergents (with concentration of 10-1 mg/ml.( was ranged from 35 mm
... Show MoreThe earth's surface comprises different kinds of land cover, water resources, and soil, which create environmental factors for varied animals, plants, and humans. Knowing the significant effects of land cover is crucial for long-term development, climate change modeling, and preserving ecosystems. In this research, the Google Earth Engine platform and freely available Landsat imagery were used to investigate the impact of the expansion and degradation in urbanized areas, watersheds, and vegetative cover on the land surface temperature in Baghdad from 2004 to 2021. Land cover indices such as the Normalized Difference Vegetation Index, Normalized Difference Water Index, and Normalized Difference Built-up Index (NDVI, NDWI, an
... Show MoreDocetaxel is an effective treatment approved for many types of cancers, but its effectiveness in clinical practice can be compromised by significant occurrence of adverse drug reactions. The aim of the current study was to measure the distribution of adverse drug reactions of docetaxel reported in Iraq and to assess the causality, severity, seriousness, preventability, expectedness and outcome of these adverse reactions. A retrospective study conducted on individual case safety reports from the Iraqi Pharmacovigilance Center / Ministry of Health. The study included 118 individual case safety report containing 236 adverse drug reactions.
Most of the adverse drug reactions were related to skin and subcutaneous tissue disorders(26.7%), f
FH Ghanim, Journal of Global Pharma Technology, 2018