Interleukin-1 β (IL-1 β) is considered to be one of the most important mediators in the pathogenesis of inflammatory diseases, particularly in neurodegenerative diseases such as multiple sclerosis (MS). MS is a chronic inflammatory disease characterized with demyelination in central nervous system (CNS). There was believe that single nucleotide polymorphisms (SNPs) in IL-1β gene can alter the structure and function of the IL-1β and consequently may have play role in MS disease. In this this study the IL-1β gene polymorphism (rs16944, rs1143634) and their association with MS in Iraqi patients were investigated. Two SNPs including IL-1β-511 (rs16944) in promoter and IL-1B+3962 (rs1143634) in encoding region, were studied using Polymerase Chain Reaction- Sequence Specific Primer (PCR-SSP) technique. The results revealed that IL-1β-511 SNP has three genotypes (CC,CT, TT) with non- significant difference in the SNP genotype and allele frequencies of MS patients compare with control group, it was also noticed that the risk allele was (C) with relative risk (RR=1.55) and higher frequency (60.77%) than T (39.23%) allele in RRMS patients. On other hand the three genotypes (CC,CT, TT) of IL-1B+3962 SNP it seem to have the same picture, that mean there was no significant difference in their frequencies between RRMS patients and control group , and the highest genotype frequency was for (CC) genotype (68.92%) and the lowest frequency was for( TT) genotype (2.88%) in patients, it was also noticed that the risk allele was (C) with odd ratio (2.44) and that the (T) frequencies were (16.98%vs. 33.33%) while (C) frequencies were (83.02 vs. 66.67%) in patients and control group respectively. Concerning with these findings, one can suggest that interleukin-1β gene polymorphisms may not be relevant to susceptibility to MS in Iraqi patients, this is probably due to many reasons such as ethnic diversity, the relevant of haplotype for this gene with other haplotype of cytokine encoding genes and finally the limitation of sample size which play critical role in SNPs studies.
Visceral Leishmaniasis (VL) is a disseminated protozoan infection caused by Leishmania donovani parasites which affects almost half a million persons annually. Classical diagnosis methods of VL still not very sensitive and time consuming. In this study, we reported the success of polymerase chain reaction (PCR) method to identify L. donovani based on kinetoplast deoxyribonucleic acid (kDNA) for the diagnosis of the parasite using in vitro promastigote cultures. LdI species - specific primer was used to identify L. donovani and the result showed a single band of about ~600bp. It can be recommended that this primer is to be used for detection the visceral L. donovani.
Background:
This paper contains studying of the Evaluation for the Petrophysical Properties of
Yamama Formation in Ratawi Field which occurs in about 70 km to the west of
Basrah city in Mesopotamia zone (Zubair subzone). The study includes a
petrophysical evaluation and (3 Dimensions) geological model for each unit
especially the three hydrocarbon units comprising the Yamama Formation in (5)
boreholes which are Rt-3, Rt-4, Rt-5, Rt-6 and Rt-7 distributed on the crest and
flanks of the Ratawi structure that are carried out in the present study. The
formation's boundaries were determined using well logs, available core intervals and
by Petrophysical data and it is found that it can be subdivided into three main
reservoir uni
This research seeks to explore the impact of notifications on enhancing user engagement with websites, primarily through user subscriptions and their interaction with notifications on these websites. The significance of this study lies in its implications for crafting compelling headlines that capture users' attention, streamline their access to journalistic content, and align with the objectives and editorial policies of news websites. It sheds light on the factors influencing users' preferences for specific notifications and their engagement with content based on their individual interests, motivations, and the satisfaction derived from such interactions.
The researcher has reached several key findings, inc
Background: Wound healing is a complex dynamical interaction between various cell types, the extracellular matrix, cytokines, and growth factors. osteoponetin is a substance that acts as an anti-inflammatory. Aims of study: The study was designed to identify the role of local exogenous applications of osteopontin on wound healing (in cheek skin). Materials and methods: Thirty adult male albino rats weighting an average of (250-300gm) used in this study, incisional wounds were made in the skin of the cheek of rat and they were divided into the following groups: A-Control group: 15 rats treated with 1µ l of normal saline B-Experimental groups: 15 rats treated with topical application of 1µl osteopontin. The scarification of animals we
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United nation determined many basic climatic effects which affect the crust of Earth.
And the most important one is the climatic change and its effect on environmental, economic,
social, and political effects. So, the amount of rain which is considered as one of climatic
changes in Iraq should be studied.So, this research explains the factors which affect rain, its
overall average, the variation in the amounts of rain, the amount of yearly rain and variation
in both yearly and monthly rains by using standard variation and yearly fluctuation.As a
result, it is concluded that the number of rainy days doesn't mean an increase in rains amount.
And there's variation in rains amount in all study areas which is contrastive
The aim of this investigation is to study and analysis the role of governance in the evaluation of the and social performance of the economic units to be addressed through the concept of corporate governance and then to the social performance and its relationship to corporate governance.
The most important obtained results from this research is that the corporate governance of extreme importance, and derive their importance from being an essential tool to contribute to the transparency and fair disclosure of the financial results of economic units in the fight against financial and administrative corruption in economic units, thus providing protection and confidence of all parties, and the evaluating soci
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Marketing plays a role in the transfer of consumer desires through research, studies and satisfy the needs process, and with the technical development has evolved and marketing departments in the world of commerce has made great strides since the expansion of the trade deal, especially in light of spread of the Internet and the culture of use where he became a lot as individuals or institutions are dealings via electronic shopping . In all cases, we find that the consumer is important party, and that the legal rules did not leave the shopping process or contracting E without protection and I've dealt with so many studies through the civil protection for the consumer in electronic contracts legally with an analytical study of the
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