The protective effect of benfotiamine against doxorubicin-induced cardiotoxicity was evaluated in rabbits. Pretreatment of rabbits with 70mg/kg benfotiamine orally 7 days before induction of cardiotoxicity with I.V 15mg/kg doxorubicin. injection resulted in significant reduction of the activities of lactate dehydrogenase and creatine phosphokinase enzyme in the serum compared to doxorubicin treated animals; benfotiamine also improves the histological changes produced by doxorubicin in the cardiac muscle compared to control. In conclusion, benfotiamine when used concomitantly with doxorubicin protects the myocardium against the cardiotoxicity induced by this cytotoxic drug.

Tamoxifen(TAM) is an effective anticancer drug. This study was conducted to evaluate the side effects of Tamoxifenon the lipid profile. 40 rats divided into 4 equal groups,3 groups were given different doses (30, 40, 50)mg/kg body weight of TAM three times a week for 8 weeks as well as control group that was given with physiological solution.At the end ofexperiment, The results showed significant differences in the treated groups were the results showed a significant degrees (p<0.05) in the HDL level in the treatment group (50mg/kg) while the three groups showed a significant increase in the levels of (Ch, TG, LDL, VLDL). The results of the study showed that Tamoxifen caused an accumulation in fats.

The possible effect of the crude aqueous extract of soy bean seeds on some blood parameters (total count of red blood cells, white blood cell , (total and differential) blood platelates, packed cell volume and concentration of blood hemoglobin) was studied in 20 albino female mice which were allocated in four experimental groups (5 mice/group). The first group was orally treated with distilled water (control group) while the second, third and fourth group were given a concentration of 4%, 6% and 8% of the extract, respectively. At the end of the daily gavaging, which lasted for 4 weeks, the animals were killed, after recording their life body weight, and blood samples were collected from each mice to study the effect

Background:  doxorubicin is one of the most active cytotoxic agents in current use, it has a very potent effect in the treatment of various malignancy either used alone or combined with other cytocidal agents, the antitumor activity of this drug associated with cytotoxic effect such as cardiotoxicity, hepatotoxicity,  nephrotoxicity, myelosuppression.

Objectives: - this study was designed to investigate the effect of the doxorubicin on the histological structure of the rats' kidney.

Results:   -  Doxorubicin cause reduction in the body weight and changes in the histological structure of the kidney which are atrophy of some  glomeruli with

    The aim of the research was to assess effects of short and long-period exposure to radiation from mobile phone on blood indices in experimental rats. In this study forty mature female rats were used; the animals were divided into two experimental group, each group consists of twenty animals. Short-period group of rats were exposed to cell phone radiation for different duration 30 m, 60 m, and 90 m per day for six weeks. Long-period group of rats were exposed to radiation from mobile phone for different duration 2h, 4h, and 6h per day for three months. The study noticed that there was significant (P≥0.05) elevation in total white blood cells and the study demonstrated significant increment (P≥0.05) in percentage of

The Influence of Some Vitamins and Biochemical Parameters on Iraqi Females’ Patients with Malignant Breast Cancer"

Background: foreign bodies Inhalation still a common problem in Iraq, occurring in both lay and professional segments of our society. Their successful removal is based on a collected experience of our thoracic surgical teams.
Patients&Methods: A prospective study of two hundred forty eight patients referred to the department of thoracic surgery of the surgical subspecialties hospital of the medical city teaching complex during the year (2007) due to witnessed or suspicion of foreign body inhalation. Patients were grouped into group 1 with definite history of foreign body inhalation and group 2 with no such history.
Results: In group 1, out of 203(81.85%) patients, about 169(83.25%) patients were pr

Background: The adverse effects of drugs can damage various organs, especially the liver, leading to a hepatic injury known as hepatotoxicity. Drug-induced liver injury (DILI) is challenging nowadays because of the large number of different drugs used, one of the offending medications that cause DILI is carbamazepine (CBZ), since the liver has an array of functions including detoxification, it will deal with several damages caused by exposure to the drugs. Objective: investigate the effect of (CBZ) 20mg/kg/day on female mice liver after 14 and 30 days of treatment on morphological and histopathological levels. Materials and Methods: 20mg/kg/day of CBZ was administered orally for (14) days to (10) female mice, another (10) mice were taking t