Preferred Language
Articles
/
ijs-6451
Prediction of Deleterious Non-Synonymous Single Nucleotide Polymorphisms (Nssnps) of Human TLR7 Gene
...Show More Authors

      Toll-like receptors (TLRs) play a key role in innate immune response activation against viruses. TLR7, one of the TLRs family, is potentially important in controlling viral infection and the production of vaccines against the virus. The wide spectrum of discrepancy in response to antiviral drugs among different populations which is emerged by some pandemics like COVID-19 might be due to their different TLR7 single nucleotide polymorphisms (SNPs). The present study aimed to investigate the consequences of 401 non-synonymous missense SNPs (nsSNPs) within TLR7 on its protein structure, stability, and function by using specific bioinformatics tools. Seven bioinformatics tools were used to investigate 401 TLR7 nsSNPs from the dbSNP database. The results showed that the six variations, rs1171508003 (R262H), rs35160120 (F580S), rs968155471 (H587Q), rs202028806 (Y871D), rs1331496205 (W933S), and rs181600414 (R1004W), were found to be extremely deleterious by all of the employed bioinformatics tools. All six variations showed an impact on the protein’s structure, function, and stability. Among them, Y871D (rs202028806) and R1004W (rs181600414) were revealed as the most damaging nsSNPs. This study suggested that the predicted six damaging variants of TLR7 could indirectly or directly destabilize the structure of protein and deviate its function to some extent.

Scopus Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Wed Jun 01 2011
Journal Name
Journal Of Economics And Administrative Sciences
Cost of human resources from a behavioral perspective
...Show More Authors

Purpose/objective:

1 - To explain the financial impact of the activities and areas of human resources management and the adoption of the methodology for estimating costs on the basis of conduct and statement of how to assess costs and benefits of human resource activities.

2 - Measuring  human capital, and its impact on the financial statements.

 

Design/methodology/approach:

 Concentrated dimensions of the research paper's lack of financial statements prepared by the organizations for information mandated human resource its components of the three (attraction - development

... Show More
View Publication Preview PDF
Crossref
Publication Date
Tue Mar 20 2018
Journal Name
Offshore Technology Conference Asia
Prediction of Hydrate Phase Equilibrium Conditions for Different Gas Mixtures
...Show More Authors
Abstract<p>Gas hydrate formation poses a significant threat to the production, processing, and transportation of natural gas. Accurate predictions of gas hydrate equilibrium conditions are essential for designing the gas production systems at safe operating conditions and mitigating the problems caused by hydrates formation. A new hydrate correlation for predicting gas hydrate equilibrium conditions was obtained for different gas mixtures containing methane, nitrogen and carbon dioxide. The new correlation is proposed for a pressure range of 1.7-330 MPa, a temperature range of 273-320 K, and for gas mixtures with specific gravity range of 0.553 to 1. The nonlinear regression technique was applie</p> ... Show More
Scopus (6)
Crossref (1)
Scopus Crossref
Publication Date
Sun Jan 03 2016
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Cardiac Myxoma Single Center Experience
...Show More Authors

Background: cardiac myxoma is the most frequent primary cardiac tumour comprising 30 to 50%, they are benign tumours. They are most often reported in women in the third to sixth decade of life.
Objectives: is to evaluate the incidence of surgery of cardiac myxomas and their presentation and outcome in IbnAl-NafeesTeaching hospital over 10 years.
Patient and Methods: This is a retrospective study that was conducted in Ibn Al-Nafees Hospital from January 2005 to December 2014 on patients with cardiac myxoma. Twenty-five patients diagnosed pre-operatively as having cardiac myxoma, they were admitted to the hospital and underwent clinical evaluation, investigation, and surgical treatment.
Result: Cardiac myxomas constituted 1% of th

... Show More
View Publication Preview PDF
Crossref
Publication Date
Mon Jul 31 2023
Journal Name
International Journal Of Sustainable Development And Planning
Monitoring and Prediction Functional Change of Land Uses Toward Urban Sustainability
...Show More Authors

Urban land uses are in a dynamic state that varies over time, the city of Karbala in Iraq has experienced functional changes over the past 100 years, as the city is characterized by the presence of significant tourist and socio-economic activity represented by religious tourism, and it occur due to various reasons such as urbanization. The purpose of this study is to apply a Markov model to analyze and predict the behavior of transforming the use of land in Karbala city over time. This can include the conversion of agricultural land, or other areas into residential, commercial, industrial land uses. The process of urbanization is typically driven by population growth, economic development, based on a set of probabilities and transitions bet

... Show More
View Publication
Scopus (2)
Crossref (1)
Scopus Crossref
Publication Date
Thu Jun 30 2022
Journal Name
Iraqi Journal Of Science
Telecom Churn Prediction based on Deep Learning Approach
...Show More Authors

      The transition of customers from one telecom operator to another has a direct impact on the company's growth and revenue. Traditional classification algorithms fail to predict churn effectively. This research introduces a deep learning model for predicting customers planning to leave to another operator. The model works on a high-dimensional large-scale data set. The performance of the model was measured against other classification algorithms, such as Gaussian NB, Random Forrest, and Decision Tree in predicting churn. The evaluation was performed based on accuracy, precision, recall, F-measure, Area Under Curve (AUC), and Receiver Operating Characteristic (ROC) Curve. The proposed deep learning model performs better than othe

... Show More
View Publication Preview PDF
Scopus (4)
Crossref (3)
Scopus Crossref
Publication Date
Fri Jun 23 2023
Journal Name
Journal Of Communicable Diseases
Downregulation of the Gene Expression of Efflux Pump Gene (acrA) and its Regulator (ramA) in Klebsiella pneumoniae by Quaternary Ammonium Compounds
...Show More Authors

Introduction: Biocides are commonly used for disinfection in a variety of contexts. They are generally used to avoid infection by controlling biofilm on medical equipment. However, the literature lacks information on the effect of biocide on efflux pump gene expression. Objective: To determine the influence of biocide on biofilm development and efflux pump acrA and ramA gene expression. Methodology: The microtiter plate method was used to identify biofilm development in 80 isolates of K. pneumoniae. The minimal inhibitory concentrations (MIC) of three biocides (quaternary ammonium compound (QAC), chlorohexidine digluconate, and chloroxylenol) were estimated. The effect of QAC on the intensity and viability of biofilms was investigated as we

... Show More
View Publication Preview PDF
Scopus Crossref
Publication Date
Wed Aug 30 2023
Journal Name
Al-kindy College Medical Journal
Investigating the Effect of Genetic Polymorphisms of Deiodinase Type 2 on Levothyroxine Dose Requirements in Patients with Hypothyroidism
...Show More Authors

Background: Hypothyroidism is the most abundant thyroid disorder worldwide. For decades, levothyroxine was the main effective pharmacological treatment for hypothyroidism. A variety of factors can influence levothyroxine dose, such as genetic variations. Studying the impact of genetic polymorphisms on the administration of medications was risen remarkably. Different genetic variations were investigated that might affect levothyroxine dose requirements, especially the deiodinase enzymes.  Deiodinase type 2 genetic polymorphisms’ impact on levothyroxine dose was studied in different populations.

Objective: To examine the association of the two single nucleotide polymorphism (SNP)s of deiodinase t

... Show More
View Publication Preview PDF
Scopus Crossref
Publication Date
Wed Aug 30 2023
Journal Name
Al-kindy College Medical Journal
Investigating the Effect of Genetic Polymorphisms of Deiodinase Type 2 on Levothyroxine Dose Requirements in Patients with Hypothyroidism
...Show More Authors

Background: Hypothyroidism is the most abundant thyroid disorder worldwide. For decades, levothyroxine was the main effective pharmacological treatment for hypothyroidism. A variety of factors can influence levothyroxine dose, such as genetic variations. Studying the impact of genetic polymorphisms on the administration of medications was risen remarkably. Different genetic variations were investigated that might affect levothyroxine dose requirements, especially the deiodinase enzymes.  Deiodinase type 2 genetic polymorphisms’ impact on levothyroxine dose was studied in different populations. Objective: To examine the association of the two single nucleotide polymorphism (SNP)s of deiodinase type 2 (rs225013 and rs225014) and le

... Show More
Scopus Crossref
Publication Date
Fri Dec 31 2021
Journal Name
Political Sciences Journal
The Impact of Political Thought on Human Rights
...Show More Authors

 Receipt date:11/19/2020 acceptance date:10/1/2021 Publishing date:12/31/2021

   Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Human rights are one of the basic concepts of modern and contemporary times, and political thought as the origin of political science and its source of knowledge have impact  in this science and its branches

... Show More
View Publication Preview PDF
Crossref
Publication Date
Thu Dec 23 2010
Journal Name
Arabian Journal Of Geosciences
Climatic prediction of the terrestrial and coastal areas of Iraq
...Show More Authors

View Publication
Crossref (2)
Crossref