Although several drugs are used against Leishmania infection but they are associated with several adverse complications. Therefore, a new effective treatment needed to be found. In this study, the effect of carbonnanotubes nanoparticles (CNTs NPs) on Leishmania donovani promastigotes was assessed. Viability of promastigotes after adding different concentrations of carbonnanotubes (CNTs) nanoparticles (0.05, 0.1, 5, 10, 20, 40, 60 and 80 μg/ml) to the parasite culture was evaluated by growth rate, viability rate assay and morphological changes. The results indicated that the effect of CNTs NPs on growth rate of promastigotes form. After exposed to 80 μg/ml of CNTs, the growth rate of promastigotes clearly decreased compared with promastigotes treated with the same concentrations of pentostam drug (the standard antileishmanial drug) and the control group. The inhibitory concentration (IC50) of CNTs NPs on promastigotes growth rate was 59.30μg/mL after 72 hours. In addition, CNTs NPs exert cytotoxic effects on L. donovani promastigotes through the induction of their death when exposed to 80μg/ml of CNTs NPs and pentostam. The inhibitory concentration (IC50) of CNTs NPs on L. donovani promastigotes was 53.79μg/mL after 72 hours. The antiparasitic effect increased with the increasing of the CNTs NPs concentration, while the viability curve of the parasite dropped. In addition, a visual inspection by light microscopy has shown that CNTs induces morphological changes in L. donovani promastigotes in comparison to the morphology of the untreated promastigotes. Our data determine the superiority of CNTs as a novel leishmanicidal effect against L. donovani infection over pentostam in vitro.
The reaction of L-ascorbic acid with the tirchloroacetic acid in the presence of potassium hydroxide gave new product Bis[O,O-2,3;O,O-5,6(chlorocarboxylicmethyliden)]Lascorbic acid (H2L) which was isolated and characterized by 1H,13C-NMR, elemental analysis (C,H,N), UV-Visible and Fourier Transform Infrared (FTIR). The complexes of the ligand (H2L) with metal ions, M+2= (Cu, Co, Ni, Cd and Hg) were synthesized and characterized by FTIR, UV-Visible, molar conductance, atomic absorption, magnetic susceptibility and the molar ratio. The analysis evidence showed the binding of the metal ions with (H2L) through the bicarboxylato group manner resulting in six-coordinated metal ion. The TLC for (H2L) and complexes showed one spot for each
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Some new norms need to be adapted due to COVID-19 pandemic period where people need to wear masks, wash their hands frequently, maintain social distancing, and avoid going out unless necessary. Therefore, educational institutions were closed to minimize the spread of COVID-19. As a result of this, online education was adapted to substitute face-to-face learning. Therefore, this study aimed to assess the Malaysian university students’ adaptation to the new norms, knowledge and practices toward COVID-19, besides, their attitudes toward online learning. A convenient sampling technique was used to recruit 500 Malaysian university students from January to February 2021 through social media. For data collection, all students
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Experimental measurements were done for characterizing current-voltage and power-voltage of two types of photovoltaic (PV) solar modules; monocrystalline silicon (mc-Si) and copper indium gallium di-selenide (CIGS). The conversion efficiency depends on many factors, such as irradiation and temperature. The assembling measures as a rule cause contrast in electrical boundaries, even in cells of a similar kind. Additionally, if the misfortunes because of cell associations in a module are considered, it is hard to track down two indistinguishable photovoltaic modules. This way, just the I-V, and P-V bends' trial estimation permit knowing the electrical boundaries of a photovoltaic gadget with accuracy. This measure
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Design and build a center basins new p-type four mirrors were studied its effect on all parameters evaluating the performance of the solar cell silicon in the absence of a cooling system is switched on and noted that the efficiency of the performance Hzzh cell increased from 11.94 to 21 without cooling either with cooling has increased the efficiency of the
Acute lymphoblastic leukemia (ALL) is a cancer of the blood and bone marrow (spongy tissue in the center of bone). In ALL, too many bone marrow stem cells develop into a type of white blood cell called lymphocytes. These abnormal lymphocytes are not able to fight infection very well. The aim of this study was to investigate possible links between E3 SUMO-Protein Ligase NSE2 [NSMCE2] and increase DNA damage in the childhood patients with Acute lymphoblastic leukemia (ALL). Laboratory investigations including hemoglobin(Hb) ,white blood cell (WBC) , serum total protein , albumin ,globulin , in addition to serum total antioxidant activity (TAA) , Advanced oxidation protein products(AOPP) and E3 SUMO-Protein Ligase NSE2[NSMCE2]. Blood samples
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في هذا البحث تم تحضير المركبات المعدنية الجديدة لأيونات البلاتين (الرباعي) و الذهب (الثلاثي) مع ليكاند قاعدة مانخ جديد مشتق من السيبروفلوكساسين . تم استخدام المعقدات بعد ذلك كمصدر لتحضير جزيئات عن طريق ترسيب المعقدات على مسام دقائق السيليكا النانوية. Si/Au2O3 Si/PtO2 تم تشخيص الليكاند و معقداته
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