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Evaluation of Silver Nanoparticles (Ag NPs) Activity Against the Viability of Leishmania tropica Promastigotes and Amastigotes In Vitro

Leishmaniasis is a disease caused by a protozoan parasite of the genus Leishmania. It is transmitted by the bite of sandfly (Subfamily Phlebotominae). Limited drugs are available for the treatment of leishmaniasis, and the general drug (pentostam) have many side effect on patients. Therefore, there is an urgent need for another drugs for the treatment of leishmaniasis.
This study aimed to develop new type of antileishmanial agents instead of classical drug (pentostam) and investigated the effectiveness of silver nanoparticles (Ag NPs) on Leishmania tropica parasites in both phases promastigote and amastigote in comparision to pentostam in in vitro condition.
This study showed the effects of Ag NPs in comparision to pentostam with different concentrations (0.3, 0.6, 0.9, 1.2, 1.5, 1.8 and 2.1 μg/ ml) on L.tropica promastigotes viability. The viability of promastigotes after 72 hr. recorded maximum cytotoxic effect of Ag NPs in highest concentration (2.1 μg/ml), it was 23.17 ± 0.45 % comparing with pentostam which was 69.33 ± 0.33 %, as well as IC50 was calculated for MTT assay and the result for Ag NPs was 1. 749 μg/ml after 72 hr., while pentostam drug did not show IC50 in all treatments.
On the other hand, the study also showed the effects of Ag NPs on L.tropica amastigote phase, and the viability was (3.10 ± 0.59 and 47.34 ± 0.87) % after 72 hr. in the highest concentration 2.1 μg/ml for Ag NPs and pentostam respectively, and IC50 was 1.148 μg/ ml for Ag NPs after 72 hr., but all results of pentostam stayed over than 50%.

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Publication Date
Thu Dec 01 2022
Journal Name
Journal Of Engineering
The Effectiveness of a Simulation Model of Thermal Insulation in Building Materials Using Cellulose Extracted from Agricultural Waste in Baghdad

This study found that one of the constructive, necessary, beneficial, most effective, and cost-effective ways to meet the great challenge of rising energy prices is to develop and improve energy quality and efficiency. The process of improving the quality of energy and its means has been carried out in many buildings and around the world. It was found that the thermal insulation process in buildings and educational facilities has become the primary tool for improving energy efficiency, enabling us to improve and develop the internal thermal environment quality processes recommended for users (student - teacher). An excellent and essential empirical study has been conducted to calculate the fundamental values ​​of the

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Publication Date
Sun Oct 01 2017
Journal Name
Journal Of Economics And Administrative Sciences
The role of Job Engagement for Employees in ensuring customer loyalty :Applied research in a Sample of private Iraq banks

ABSTRACT

      The current research aims at highlighting the role of engagement of a sample of employees who works in some of the Iraqi private banks in terms of their interaction , commitment and enthusiasm and the positive impact they own regarding their job and devote their efforts to achieve the core purpose  which is customer loyalty. The problem was expressed through a number of intellectual and practical questions.

In order to achieve the aim of the research the quantitative analytical method was used depending on a questionnaire as a basic tool to collect research data and the qualitative survey method depending on semi-structured interviews which were distrib

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Publication Date
Thu Jan 01 2015
Journal Name
Al–bahith Al–a'alami
News coverage of Arab revolutions in satellite channels An analytical study of the news bulletins in Al - Tijah satellite channel

The news media material to any means of mass media, and increasingly

 important in TV; what the associated word and image effects, which do different cover events (political, economic, sports, and social .... etc.) directly from the event site and gather the news and do prepared formulation and arranged within the framework provided by the newsletter, as it requires the viewer to provide the public with information about this news correlated; to achieve the greatest gravity following the shapes and styles and technical fees (Alkraveks) during the submission. What we are witnessing today from technological developments help existing staff to cover the news activity quickly and efficiently prohibitivel

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Publication Date
Thu Mar 01 2012
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
The Commitment of Public Companies in disclosure requirement of Financial Statement: Analysis Study in State Company for Leather Industries (SCLI)

It has been an increase concern of scientific and professional accounting sides on disclosure especially after appearance of business firms and accounting development with its relationship to financial statements which are considered to be outputs of the activity results.  The preparing of financial statements and auditing of those accounts according to normal principles and standards of accounting on both local and international levels. Accounting disclosure can be seen an importance through discover all fundamental and necessary information for proper supply. Therefore, the research will highlight on public companies commitment in Iraq for basis and standards which have taken disclosure in financial data. The conceptual frame of t

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Publication Date
Fri Dec 08 2023
Journal Name
Iraqi Journal Of Science
Spectrophotometric Determination of Thymol in Pharmaceutical Preparations Via Oxidative Coupling Reaction with 2,4- dinitrophenylhydrazine in the Presence of Potassium Periodate

A new, simple and sensitive spectrophotometric method for the determination of Thymol in pure and mouth wash preparations has been proposed in this study. The method was based on oxidation of 2,4-dinitrophenylhydrazine with potassium periodate and coupling with Thymol in alkaline medium to form an intense violet water-soluble dye that is stable and has a maximum absorption at 570 nm. A graph of absorbance versus concentration shows that Beer’s law was obeyed over the concentration range of 0.25-10 μg.mL-1 of Thymol, with detection limits of 0.063 μg.mL-1. All experimental parameters that affect the development and stability of the colored product were carefully studied and the proposed method was successfully applied to the determina

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Publication Date
Fri Oct 01 2021
Journal Name
Journal Of Engineering
Analytical and Experimental Study of the Piles Cap Normal and Light Weight Aerated Concrete: Literature Review

The main objective of this study is to understand the work of the pile caps made of lightweight aerated foam concrete and study the many factors affecting the ability and the capacity of the shear. The study was done by analyzing previous practical and theoretical experiences on the reinforced concrete pile caps. The previous practical results indicated that all specimens failed by shear diagonal compression or tension modes except one specimen that failed flexural-shear mode. Based on test specimens' practical results and behavior, some theoretical methods for estimating the ultimate strength of reinforced concrete pile caps have been recommended, some of which evolved into the design documents available on the subject.

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Publication Date
Tue Jan 01 2019
Journal Name
Energy Procedia
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Publication Date
Sat Apr 01 2023
Journal Name
Iop Conference Series: Earth And Environmental Science
GH and IGF-2 Histological Effects on the Heart, Liver and Gizzard of Chickens were Studied

GH and IGF-2 were examined histologically in the present study on adult hens to learn more about the organs’ responses to GH and IGF-2. Cardiac protein synthesis is stimulated by GH and IGF-2, according to microscopic examination. The recent research found a considerable amount of adipose tissue in the cardiac muscle bundles, which is linked to the metabolic process. In addition, GH and IGF-2 were shown to promote protein synthesis and mitosis in liver and gizzard tissues, according to the research. In addition, the apoptosis, regeneration, and secretory activity of gizzard glands are increased by the aforementioned hormones.

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Publication Date
Fri Dec 01 2023
Journal Name
Iop Conference Series: Earth And Environmental Science
Improving the Growth and Production of Beets by Fertilizing with Fish Water and Spraying Lentil Extract
Abstract<p>The experiment was conducted in the fields belonging to the Department of Horticulture, College of Agricultural Engineering Sciences, University of Baghdad, at Al-Jadriya Complex / Station A, for the autumn season of 2022-2023. The aim was to study the effect of water fish irrigation and water lens plant extract foliar application on the growth and productivity of beetroot. The experiment included two factors: the first factor was water fish irrigation with five concentrations (A) Control treatment (irrigation with river water and recommended fertilization), (B) Water fish irrigation at 25% concentration, (C) water Fish irrigation at 50% concentration, (D) Water Fish irrigation at 75%</p> ... Show More
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Publication Date
Wed May 25 2022
Journal Name
Iraqi Journal Of Science
Transverse Direction Loading Effect on the Elasticity and Strength of Micro and Nano Silica Oxide Composites

      Using three-point bending experiments,  the effect of the particle size of SiO2 on the flexural properties of epoxy composites was investigated. Young modulus and flexural strength were studied for different weight percentage of filler  (2,4,6,8 and 10) wt%.The size of SiO2 particles varied from micro (100um) to nano (12nm) .

Flexural strength and  Young modul were found to increase with the filler content, but when the particle size decreased to the nanoscale, the  Young module  increased. Flexural strength was higher for microcomposites than nanocomposites.

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