The level of thyroid autoantibodies between type 1 and type 2 diabetes mellitus
patients in Baghdad City were investigated.
Fifty individuals (25 female and 25 male) with type-1 DM in the age group of 10
to 35 years and seventy (35 female and 35 male) of having type-2 DM in the age
group of 33 to 60 years were investigated. A control group of twenty-five nondiabetes
was included. Serum sample collected was used to estimate anti-TPO, TG
and thyroid stimulating hormone antibodies (thyroid stimulating immunoglobulin
TSI and thyrotropin binding inhibitory immunoglobulin TBII) by using enzymelinked
immunosorbent assay (ELISA) technique.
The results show that there is a significant (p< 0.05) increase in the level of
thyroid peroxidase antibody (TPO-Ab) in female patients with T1DM and T2M
compared with control non-diabetes group. Furthermore, there is no significant (p<
0.05) difference in the level of TPO-Ab and Tg-Ab in male patients with T1DM and
T2DM compared with non-diabetes group. The results of this study also demonstrate
that there is a significant (p< 0.05) increase in the level of thyroid stimulating
immunoglobulin (TSI) in male patients with T1DM compared with control nondiabetes
group. In addition, there is no significant (p< 0.05) difference in the level of
TSI in female patients with T1DM and male and female with T2DM compared with
non-diabetes group. These results also illustrate that there is significant (p< 0.05)
increase in the level of thyrotropin binding inhibitory immunoglobulin (TBII) in
female and male patients with T2DM compared with control non-diabetes group.
Furthermore, there is no significant (p< 0.05) difference in the level of TSI in
female and male patients with T1DM compared with non-diabetes group.
From this study, it concluded that the presence of antithyroid peroxidase (TPO)
antibodies is helpful in predicting the development of autoimmune thyroid disorders,
especially hypothyroidism. Subclinical hypothyroidism has a negative influence on
lipid metabolism and it is an independent risk factor for myocardial infarction.
The aim of this study is to evaluate oxidative stress in diabetes mellitus (DM) Type1 by the measurement of Glucose-6-phosphate Dehydrogenase (G-6-PD), an enzyme expressed in human RBCs, is important in the generation of reduced glutathione which is the key product in oxidative stress controls. The Study was carried on 80 samples of blood and serum of National Diabetes Center (NDC). The study groups under fasting conditions and they divided as:20 samples of diabetes mellitus patients without complications and 20 samples of diabetes mellitus with cardiovascular (CV) complications and 20 samples of diabetes mellitus with Nephropathy (Neph) complications compared with 20 control group with average age (13-67) years.. The results sh
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Summary: Background: There is an epidemic of several non communicable diseases and metabolic abnormalities in humans including hypertension, obesity, hyperlipidemia, low high density lipoprotein cholesterol, microalbuminurea, and insulin resistance. These diseases and metabolic abnormalities have been collectively classified as metabolic syndrome and are closely associated with type 2 diabetes and other health problems including death. objectives: To investigate the prevalence of metabolic syndrome among type 2 diabetic patients in Baghdad teaching hospital,the frequency, and distribution of risk factor
We have investigated twenty five patients with type-2 diabetes mellitus aged (35-60) years and fifteen healthy persons as control group to detect Anti-Helicobacter pylori IgG antibody. All studied groups were carried out to measure fasting blood sugar, anti- Glutamic acid decarboxylase (GAD), anti-? islets cells antibody by IFAT, Anti-H. pylori IgG antibody by ELISA technique. There was significant elevation in the concentration of fasting blood sugar than in control group (P < 0.05), the patients had negative results for anti-GAD antibody and anti- ? islets cells antibody, there were significant differences (P < 0.05) of anti-H. pylori IgG antibody in 28 % of patients had type-2 diabetes than control group. This lead to suggestion that typ
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Diabetes mellitus is a common health problem worldwide counting about 1.2 million cases in Iraq in 2015. Taking in account of the patient’s beliefs about the prescribed medication had been reported to be one of the most important factors that affects adherence where holding positive beliefs about medications is a prerequisite for intentional adherence. The aim of the current study was to investigate and assess beliefs about medicines among type 2 diabetic patients and to determine possible association between this belief and glycemic control as well as some patient-specific factors. This study is a cross-sectional study carried out on 380 (mean age 56.58± 10.06 years) already diagnosed T2DM patients who attended the National Diabetes
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Objective(s): to assess the effectiveness of educational program on improving diabetic foot self-efficacy concerning managing their feet. Methodology: A descriptive analytic (quasi – experimental) design study was carried out at Diabetic and Endocrinology Center in Baghdad- Rusafa Sector from 2nd of May 2017, to27th June 2018. Non-probability sample of (80) male and female diabetic patients were selected. The study instruments consisted of two major parts: first
Urotensin-II (UII), a pluripotent vasoactive cyclic peptide, exhibits the progression of cardiovascular diseases and the glucose metabolic disorder of insulin resistance. Type 2 Diabetes Mellitus (T2DM) is entirely associated with insulin resistance. This study aimed to demonstrate the association of UII with insulin resistance in diabetic and non-diabetic subjects. A total of 73 male and female subjects aged 40-60 years were recruited in this case-control study. They included 35 non- diabetic subjects with a body mass index of (BMI) ≤ 25 and 38 patients with Diabetes Mellitus and BMI ≥ 25. UII levels were assessed beside other vasoactive and clinical parameters. The results re
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Type 2 diabetes mellitus is often characterized by hyperglycemia as a result of increased insulin resistance in hepatic/peripheral tissues and pancreactic B-cell dysfunction. Approximately 92% of patients with type 2 diabetes mellitus demonstrate insulin resistance, however hyperglycemia is always a consequence of insulin deficiency. This study was done on 120 patients newly diagnosed diabetes type 2 characterized by dyslipidemia that is increased triglycerides and decreased HDL. Hypoglycemia and weight gain are common problem with oral sulfonyl urea drugs. In this work three different oral hypoglycemic drugs repaglinide and glibenclamide (insulin secretagogues) and rosiglitazone (insulin sensitizer) were used for treatment of patients w
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(2)
Rheumatoid arthritis is a chronic inflammatory autoimmune disease its etiology is unknown . The classical autoimmune diseases, have adaptive immune genetic associations with autoantibodies and major histocompatibility complex(MHC) class II such as rheumatoid arthritis (RA), diabetes mellitus type two (DM II). Serum of99 males suffering from RA without DMII as group (G1), 45 males suffering from RA with DM II as group (G2) and 40 healthy males as group (G3) were enrolled in this study to estimation of alkaline phosphates (ALP),C-reactive protein(CRP) and Pentraxin-3(PTX). Results showed a highly significant increase in PTX3 levels in G1 and G2 compared to G3 and a significant decrease in G1comparing to G2. Results also revealed a si
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Background: Inflammation and more specifically inflammatory cytokines are determinant in the development of microvascular diabetic complications, including neuropathy, retinopathy and nephropathy.
Objective: The aim of present study is to evaluate the relationships between high sensitive C-reactive protein, microalbuminuria and risk factors for cardiovascular disease.
Subjects and methods: the study involved (30) patients with type 1 diabetic mellitus compared to (30) healthy control. A fasting blood sample was drawn from all subjects after an overnight fasting to measure the biochemical parameters which including glycated hemoglobin, lipid profile, atherogenic index of plasma and high sensitive C-reactive protein concentration in