This study was done to find a correlation between adipokines such as tumor necrosis- alpha (TNF-α) and autoantigens such as anti-tyrosine phosphatase (IA2) with obesity and type 2 diabetes mellitus (T2DM). For this purpose, one hundred forty adult males were selected. 90 of them were diagnosed with type 2 diabetes and 50 healthy males). The subjects were divided into four groups. Group 1 had healthy controls with body mass index (BMI) between 18.5-25, group 2 had individuals who suffered from obesity only (BMI above 30), group 3 consisted of diabetes patients and group 4 had individuals who were diagnosed with both obesity and diabetes. The enzyme immunoassay was intended for quantification determination of TNF in serum. The results found a significantly (p≤0.001) higher concentration of TNF-α (21.01 ± 1.27 pg/ml) in patients suffering from both obesity and diabetes in comparison with the control (5.33 ± 0.67 pg/ml), obese patients (12.63 ± 1.35 pg/ml) and diabetes patients group (13.32 ± 0.83 pg/ml). Chi-square analysis found a significantly (p≤0.001) higher prevalence of abnormal TNF-α in males suffering from both obesity and diabetes, 73.33% compared with diabetes non-obese males 31.1%. A significant positive correlation (p≤0.01) was found between TNF-α with BMI (r= 0.65) and HbA1c (r= 0.57). No significant differences in IA2 concentration were observed between all groups.Also no significant correlation was observed between IA2 with BMI and HbA1c.
MM ABDUL-WAHHAB, SA AHMED, International Journal of Pharmaceutical Research, 2020 - Cited by 2
One of the scientific education aims, preparing a student able to keep up with the scientific developments and innovations around him and make him contribute, adapt, investment and continue development. The concepts of nanotechnology from scientific innovation open up an important area of thinking and intervention in the field of chemistry applications in daily life, the technological changes lead to social, political and economic changes which result that the students to have the knowledge, understanding, awareness, appreciation and sense in applications of modern technology for their use optimally, in order to cope with these scientific and technological changes. The research aims at finding out the correlation between the acquisi
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