This study was performed to assess the correlation of serum interleukins (ILs) levels with anthropometric data and lipid profile status in blood samples obtained from 100 Iraqi obese women with polycystic ovary syndrome PCOS. Obese non PCOS healthy women (n=75) matching in age (19-38 years) and body mass index(29.9-33.4kg/m2) served as a control group. The samples were collected from Kamal Al-Samurai Teaching hospital during the period of December 2017- June 2018.ELISA kits were used to measure serum levels of IL-6,IL-10,IL-18, IL-29,IL-33,tumor necrotic factor (TNF-α),high sensitive C-reactive protein (hsCRP), insulin, total testosterone, and sex hormone binding globulin(SHBG).The biochemical measurements of blood glucose and lipid profile were performed by conventional colorimetricmethods. The results demonstrated significant differences(P < 0.01) in serum levels of all interleukins and lipid profile parameters in obese PCOS in comparison with obesenon PCOS control women.In addition, PCOS women had higher insulin and FAI levels in comparison to non PCOS women. The findings suggest that androgen excess, indicated by high free androgen index (FAI),might serve as an indicator of a prediabetic status, as it might promote insulin resistance and ð›½-cell dysfunction in PCOS women. Circulatory interleukin levels in obese PCOS women may act on the development of insulin resistance and androgen oversupply in PCOS,suggesting that high serum ILs levels were related to insulin resistance (IR) and androgen excess but not to body mass index. A high IL level is not an elemental characteristic of PCOS, but it may act in promoting IR and hyperandrogenism of PCOS.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder. To determine the metabolic disorders in women with PCOS, (25) women with PCOS ages (15 - 47) years have been investigated and compared with (20) healthy individuals. All the studied groups were carried out to measure fasting blood sugar, (anti-GAD Ab, anti β-islet cell Ab by IFAT) and measured insulin level by ELISA. There was significant elevation in the concentration of fasting blood sugar than in control groups (p ≤ 0.05) and there was negative results for anti-GAD Ab and anti β-islet cell Ab by IFAT test for serum of women with PCOS, while there was significant differences in the insulin level for women with PCOS compared with control groups (p ≤ 0.05),
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Background: In advanced diabetes mellitus, serum levels of the most hormones are altered due to several interplaying mechanisms. Objective: To assess the relation of serum leptin and lipid profile in type 2 diabetic nephropathy. Patients and Method: Serum leptin levels and its relation to lipid profile were estimated in 62 patients with type 2 diabetic nephropathy attending the National Diabetes Center in Al- Mustansiriya University, and (26) healthy individuals considered as control group. The diabetic patients were classified into three groups, (24) pathients with normoalbuminuria (21) patients with microalbuminuria and (17) patients with macroalbuminuria. Fasting plasma glucose, serum creatinine, Hb A1c %, lipid profile (Total c
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Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disease that affects approximately 15% of women of childbearing age worldwide. It is one of the causes of infertility and is characterized by hirsutism, acne, persistent or interrupted anovulation, and hyperandrogenemia. Neuregulin-4 (NRG-4) is an adipokine hormone from the protein neuregulin family. Its level is greater in PCOS than in control women, and Neuregulin-4 is linked to body fat percentage and liver fat, as well as insulin resistance (IR).
Objectives: To estimate the serum NRG-4 levels in women diagnosed with (PCOS), to compare it with, non-PCOS healthy control and to explore the effect of hyperandrogenism on the obtained r
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Background: Polycystic ovarian syndrome is one of the common gynaecological diseases encountered nowadays in the gynaecological clinic. Many criteria and diagnostic test had been evolved to be used with different classifications methods.Objectives: The present study aimed to measure the anti-mullerian hormone levels in serum of the women with Polycystic Ovary Syndrome and to test the possibility that if it can be used as a marker for diagnosis of polycystic ovary syndrome patients.Methods: A cross sectional study that had been conductedat Kamal AL-Samaraee Hospital, AL-Suwayrah Hospital andAl-Elwiya Maternity Teaching Hospital during the periodfrom July, 1st, 2013 – Jan. 1st, 2014. Where forty women withPolycystic ovarian syndrome (wit
... Show MoreBackground: Polycystic ovary syndrome (PCOS) is one of the common female endocrine disorders of uncertain etiology, which causes menstrual disorders as well as infertility. Interleukin–33(IL-33) is considered as a strong risk marker of inflammation and may have possible role in pathogenesis of PCOS.
Objectives: The present study is designed to investigate the possible role of IL-33 in pathogenesis of PCOS and its relation with glycated hemoglobin (HbA1C),insulin resistance(IR) and oxidative stress in prediabetic PCOS patients.
Subjects and Methods: The study involved 30 healthy women as control group and sixty six infertile Iraqi women with PCOS which were divided into two groups according to glycated heamoglobin(HbA1c) value and
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Abdominal fat synthesizes a variety of adipokines, including vaspin and chemerin, that affect the resistance to insulin. This research was conducted to demonstrate the effect of pioglitazone, one insulin sensitizer used to decrease insulin resistance, on these adipokines in obese patients with polycystic ovary (PCOS). Twenty-five obese women with PCOS were treated with pioglitazone 15mg/bid for 12 weeks. Modifications in fasting blood glucose (FBG), serum fasting insulin (FSI), chemerin and vaspin serum levels, follicle stimulation hormone (FSH), luteinizing hormone (LH), testosterone (T), and in baseline and post-therapy were assessed. Body mass index decreased without any substantial variance after 12 weeks of piogl
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Polycystic ovary syndrome (PCOS) is a prevalent condition in women of reproductive age. It is characterized by androgen excess and chronic anovulation. Some trace elements, macroelements, and heavy metals have been linked to pathophysiological mechanisms of PCOS .
To study the alterations in the serum levels of the trace element manganese (Mn), some macroelements, magnesium(Mg) and calcium (Ca), and the heavy metals cadmium (Cd) and lead (Pb), in obese and non-obese PCOS patients; and the association of these alterations with some of the hormonal changes occurring in PCOS.
The study was carried out at Kamal Al-Samarrai Hospital (Center for Infertility treatment and in vitro Fertilization "IVF") Baghdad- Iraq. Eig
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Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women, at reproductive age. PCOS is a chronic hyperandrogenic state that has many significant short-term and long-term implications for patients such as oligomenorrhea, amenorrhea, infertility, diabetes mellitus, cardiovascular disease, increased risk of endometrial cancer, and hirsutism. Objectives: To evaluate the obesity and glycemic criteria among women with polycystic ovary syndrome. Method: A case control designed study was carried out at the National Diabetes Center (NDC) / Al-Mustansiryia University; on 50 participants formed the PCOS group and 50 healthy control participants. Data collected about age, age at menarche and BMI. Also, blood sam
... Show MorePolycystic ovarian syndrome (PCOS) is a well-known endocrinopathy and one of the most frequent endocrine-reproductive-metabolic syndromes in women, which can result in reduced fertility. While the actual cause is unknown, PCOS is regarded as a complicated genetic characteristic with a great degree of variability. Moreover, hormones and immune cells, including both innate and acquired immune cells, are thought to interact in PCOS. Chronic low-grade inflammation raises the risk of autoimmune disease. The study's purpose is to investigate the chemokine monocyte chemoattractant protein-1 (MCP-1) and fertility hormones in samples of women patients with polycystic ovary syndrome (PCOS) in the City of Medicine. Sixty PCOS women comprise 30 heal
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