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Profile of Some Cytokines in Sera of Children with Autism Syndrome

Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies
characterized by impairment in social interactions and communication deficits. A
potential role for immune dysfunction has been suggested in ASD. To test this
hypothesis, certain cytokines: IL-2, IL-10, IL-12, IL-17A and IFN-γ were
investigated in serum of all participants. The study includes: 39 child (male and
female) aged < 5 to10 years with confirmed diagnosis of autism using standard
assessment, age and gender matched 24 confirmed healthy children and 19 non
autistic siblings used as controls. Serum was isolated and cytokines were detected
using enzyme linked immunosorbent assay (ELISA). The observations indicate a
significant increase (P < 0.05) in autistic patients serum levels of IL-10 compared
with healthy control, but with lack of significant difference with their related non
autistic siblings. Whereas detection of IL-12 and IFN-γ in the autistic patients serum
showed significantly decrease level (P < 0.05) compared with healthy control, but
with lack of significant difference with their related non autistic siblings. On the
other hand, detection of IL-2 and IL-17A results showed no significant (P > 0.05)
differences compared with healthy control and non autistic siblings.

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Publication Date
Mon Apr 01 2013
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The effects of growth hormone replacement therapy on insulin, lipid profile and calcium in children with growth hormone deficiency

Background: Growth hormone has multiple effects on the overall form and function of growing body. Aside from these growth stimulating functions, it has marked effects on energy metabolism, it acts on fat cells to reduce the amount of stored fats, promotes protein synthesis in cells and plays a role in regulating the sugar levels in the blood.

Objective: to investigate the effect of growth hormone replacement on lipid profile, insulin level, glucose and calcium level in patients with growth hormone deficiency (GHD).

Method: A prospective study of 49 children; 37 boys  and  12girls  with a mean age(13.5±3.3)years   attending the Children Welfare Te

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Publication Date
Sun Apr 03 2016
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Guillian Barré Syndrome in a sample of Iraqi Children: Seasonal and sex variation

Background: Seasonal variation and gender preponderance have not been adequately studied in Guillain-Barre syndrome (GBS).
Objective: This study aims to evaluate the seasonal variation and sex preponderance in children with Guillian Barré Syndrome.
Patients and methods: A cross sectional study was carried out by reviewing wards’ registry of all cases with Guillian Barré Syndrome admitted to Children Welfare Teaching Hospital during a 10-year period (1999 - 2008). Age, sex, seasonal distribution, residence and outcome were analysed.
Results: Guillian Barré Syndrome was diagnosed in 217 (126 boys, 91 girls) patients and the annual hospital rate of admission was 22.9 /100000 children. There was increase annual incidence from 1

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Publication Date
Sat Dec 31 2016
Journal Name
Al-kindy College Medical Journal
CLINICAL PRESENTATIONS AND COMPLICATIONS OF GUILLAIN BARRE SYNDROME IN CHILDREN WELFARE TEACHING HOSPITAL

Background: Guillain Barré syndrome is an acute inflammatory demyelinating disease of the peripheral nerves. Its synonyms are: acute inflammatory demyelinating polyradiculoneuropathy, idiopathic polyneuritis, acute infective polyneuropathy and post infections polyneuritis. Objectives: We attempt to study the clinical presentations and complications in patients with GBS who were admitted to children welfare Teaching Hospital and to compare the results with the other studies.Type of the study: A retrospective study.Methods: A study done on seventy patients with GBS who were admitted to children Welfare Teaching Hospital in Medical City-Baghdad from different parts of Iraq between January 2002-December 2006.Results: Forty (57.14%) of them

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Publication Date
Sun Oct 01 2017
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Evaluate the correlation of Inflammatory Cytokines with Chlamydia pneumonia in Coronary Atherosclerotic Patients

Background: Coronary atherosclerosis is an inflammatory disease, caused by high concentrations of plasma cholesterol, in particular those with high concentrations of low-density lipoprotein cholesterol, which considered as one of the principal risk factors for atherosclerosis.
Objective: The study focused on detecting risk factors and biomarkers for coronary atherosclerotic in order to develop interventions preventing their progressions.
Patients and Methods: The present case control study was carried out between December 2012 and May 2013, in Hawler cardiac center, 74 coronary atherosclerotic patients were enrolled in our study (44 males and 30 females), their age ranged between 30 years to 75 years old, 25 (33.8%) were type 2 dia

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Publication Date
Sun Oct 01 2006
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Some Immunological Profile of Rheumatoid Arthritis

Seventy- four cases of clinically diagnosed Rheumatoid Arthritis (RA), fifty cases of systemic lupus erythematosus (SLE), and thirty healthy normal controls were investigated for detection of rheumatoid factor (RF), total serum immunoglobulins (Igs), antinuclear antibody (ANA), and ANA subtype anti-double stranded DNA (anti-ds DNA).
Patients with RA showed 58.1% positive for RF comparable with 14% positivity in SLE patients and 6.6% in normal individuals. Serum Igs (IgA,IgG) were found to be elevated in RA and SLE
patients (62.2% , 36.5%) (54% , 38%) respectively. This study revealed that ANA is found in 88% of SLE patients sera and 78% of these ANA is ds DNA in comparison with only 6.8% of RA sera wer

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Publication Date
Wed Mar 16 2022
Journal Name
Journal Of Educational And Psychological Researches
Awareness of Diagnosing Autism Spectrum Disorders and Social (Pragmatic) Communication Disorder among Student Teachers According to Some Variables

The research aims to identify the level of awareness of student teachers in the behavioral disorders and autism specialization about the diagnosing Autism Spectrum Disorder and Social (Pragmatic) Communication Disorder according to some variables. The study was conducted on a sample of (113) student teachers. The researcher employed the awareness scale of a teacher-screening questionnaire for autism spectrum disorder and social pragmatic communication disorder. The results showed that the average of teachers in the total degree of awareness of autism spectrum disorder and social communication have recorded a moderate degree. As for the awareness of autism spectrum disorder was high. Then, the awareness of social communication disorder wa

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Publication Date
Sun Dec 05 2010
Journal Name
Baghdad Science Journal
Measuring the concentration of some hormones in patients sera of polycystic ovaries

Extensive evaluation of 76 women with polycystic ovary syndrome compared with 25 fertile women as control group was achieved by routine investigations and hormonal study of each female which were done in one period during the menstrual cycle. Then the women with PCOS have been divided into 2 groups according to their menstrual cycle (irregular menstrual cycle) during assessing their hormonal profiles as follow:- 1- (54) Patients with oligomenorrhea. 2- (22) Patients with menorrhea. This study shows that the women with PCOs have different clinical features taken from a history of disease of all of the women. Those features were distributed as follow: 57.92% of them suffer from hirsutism. 19.24% suffer from irregular menstr

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Publication Date
Sun Jun 07 2015
Journal Name
Baghdad Science Journal
Study of Some Biochemical Parameters in Iraqi Children with Acute Lymphoblastic Leukemia

Leukemia or cancer of the blood is the most common childhood cancer, Acute lymphoblastic leukemia (ALL), is the most common form of leukemia that occurs in children. It is characterized by the presence of too many immature white blood cells in the child’s blood and bone marrow, Acute lymphoblastic leukemia can occur in adults too, treatment is different for children. Children with ALL develop symptoms related to infiltration of blasts in the bone marrow, lymphoid system, and extramedullary sites, such as the central nervous system (CNS). Common constitutional indications consist of fatigue (50%), pallor (25%), fever (60%), and weight loss (26%). Infiltration of blast cells in the marrow cavity and periosteum often lead to bone

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Publication Date
Sun Oct 01 2023
Journal Name
Journal Of The Faculty Of Medicine Baghdad
A Cross-Sectional Study of Urinary Neutrophil Gelatinase-Associated Lipocalin and its Association with Steroid Responsiveness in Iraqi Children with Idiopathic Nephrotic Syndrome

Background: Steroid-resistant nephrotic syndrome (SRNS)is associated with serious complications and financial burdens. Studies reported increased urinary neutrophil gelatinase-associated lipocalin (uNGAL) levels in children with idiopathic nephrotic syndrome (INS).

Objectives: This study aimed to evaluate the uNGAL potential to distinguish SRNS from steroid-sensitive nephrotic syndrome (SSNS) in Iraqi children.

Patients and Methods: Children with SRNS (n=31) and SSNS (n=32) were recruited from Babylon Hospital for Maternity and Pediatrics from March to June 2022. Patients' data included demographics, clinical characteristics, and urinary lab tests. The uNGAL concentrations

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Publication Date
Sun Oct 03 2010
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Role of Pro- and Anti-Inflammatory Cytokines in Rheumatoid Arthritis: Correlation with Disease Activity.

Background: Rheumatoid arthritis (RA) is a chronic and debilitating autoimmune disease characterized by chronic inflammation with subsequent cartilage and bone destruction. Cytokines are  key mediators of inflammation and can be found in abundance both in the joint and blood of patients. This study was designed to evaluate the role of pro- and anti-inflammatory cytokines in pathogenesis of RA, as well as study the correlation among these cytokines.
Patients and methods: Forty patients with RA and thirty age-matched healthy controls were included in this study. Serum cytokines were measured by enzyme-linked immunosorbent assay.
Results: The serum levels of pro-inflammatory cytokines (IL-1α, IL-2, IL-6, IL-8

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