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Seroprevalence of Toxoplasmosis in patients with chronic liver disease in Baghdad

The influence of Toxoplasma gondii in the pathogenesis of hepatic disease has lately  had considerable attention. The objective of this study is to assess the seroprevalence of T. gondii infection in patients with chronic liver disease from Baghdad-Iraq. All patients have attended Gastroenterology and Hepatology  Teaching Hospital, Medical city in Baghdad, Iraq An analytical case–control study was achieved from September to November 2018. Seventy male patients with chronic liver disease (CLD) and 70 control males  (free of chronic liver diseases) participated in this study, their ages were between (18-80) years old. Serum samples were taken from all subjects and were analysed with enzyme-linked immunosorbent assay (ELISA) for the presence of anti-T.gondii IgG and IgM antibodies. The prevalence of anti-T.gondii IgG was significantly higher 62.85% in CLD patients compared with 27.28% in the control subjects. Anti-T. gondii IgM antibodies were also showed to be significantly higher in CLD patients compared with control subjects. A significant relation between age and the prevalence of T.gondii was reported in this study. Toxoplasmosis was largely reported among those aged (˃40) years old for both CLD patients and control subjects, while the other age groups showed less seroprevalence rates.

     Sera samples for both CLD patients and control subjects were tested for different liver enzyme: aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). ALT was greater in CLD-Toxoplasma positive patients comparing to CLD-Toxoplasma negative patients. In addition to AST was higher in control-Toxoplasma positive subjects comparing to control-Toxoplasma negative subjects.

     These findings show that Toxoplasmosis is high expected to be diagnosed with chronic liver disease patients. Consequently, attention would be focused on health education of peoples at high risk of toxoplasmosis.

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Publication Date
Fri Jun 30 2023
Journal Name
Iraqi Journal Of Science
Effect of Liver Enzymes, Oxidative Stress and Vitamin D3 in Psoriatic Patients

     Psoriasis is one of the skin’s chronic inflammatory diseases. Psoriasis etiology isn’t exactly known. Recently, it has been suggested that the imbalances in oxidant-antioxidant status happening because of the increase in reactive oxygen species production (ROS) and/or deficient function regarding the antioxidant system might be included in psoriasis pathogenesis. The major goal is to evaluate the antioxidant defense status in patients experiencing psoriasis and oxidative stresses represented by malondialdehyde (MDA) level and evaluate liver enzymes and vitamin D3. There are some tests of biochemical parameters and vitamins (GSH, MDA, VitD3, SOD, GPx, CAT, AST, ALT, and ALP) are conducted on 35 patients experiencing psoriasi

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Publication Date
Sat Nov 28 2020
Journal Name
Iraqi Journal Of Science
Serum Level of Interleukin-35 in Patients with Chronic Hepatitis B Virus Infection

Interleukin-35 (IL-35) is a new member of IL-12 family of cytokines, and its role in pathogenesis of hepatitis B virus (HBV) infection has been recently suggested. Accordingly, a case-control study was conducted during June - October 2018 to determine IL-35 serum level in Iraqi patients with chronic HBV infection. The results revealed that IL-35 level was significantly decreased in patients as compared to control (163 vs. 301 pg/ml; p < 0.001). However, such decreased level was more pronounced in patients at the age groups < 40 and 40 – 50 years (165 and 145 pg/ml, respectively) as compared to the corresponding age groups in control (482 and 234 pg/ml, respectively). In the case of gender groups, both male

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Publication Date
Wed Oct 07 2020
Journal Name
Indian Journal Of Forensic Medicine &amp; Toxicology
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Publication Date
Tue Jun 01 2021
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The Effect of Cigarette Smoking on Serum Liver Enzymes in Baghdad

Smoking is the most noticeably horrible human conduct; it is rehearsed by individuals dependent on nicotine numerous hurtful sicknesses, for example, cancer and liver disorder are brought about by smoking cigarettes. So this study aimed to study some of the liver function represented by the enzymes aspartate aminotransferase (AST or GOT) and alanine aminotransferase (ALT or GPT) in smokers and non-smokers for 50 persons in a group consists of 25 smokers and 25 non-smokers of different ages and to study the effectiveness of cigarette smoking on liver enzymes by checking the secretion of (AST) (35.84± 4.1)U/ 1 (ALT)(51.08±7.286 ) U/1(p<0.05) relative to non-smokers were significantly correlated with heavy cigarette smoking.

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Publication Date
Mon Nov 02 2020
Journal Name
International Journal Of Pharmaceutical Research
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Publication Date
Sun Dec 27 2020
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
CYP2D6 Genotype in Relation to Liver Toxicity Due to Tetrabenazine in Iraqi Patients with Hyperkinetic Movement Disorders

Abstract

The  common types of movement disorders are ; dystonia which is a syndrome  of  repetitive muscle contractions. While , Huntington disease is autosomal dominant progressive neurodegenerative disorder, which is characterized by involuntary movements (“chorea”).

Tetrabenazine therapy has been shown to effectively control this movements compared with placebo.

Design the proper dosing approach for patients treated with tetrabenazine with genotype polymorphisms and their hepatic effect on patients.

A prospective case controlled study was carried on 50 patients whom    divided into 2 groups :first group involved 25 patients who had cho

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Publication Date
Tue Jul 01 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Detection of Cd69 Marker by Flow Cytometry in Iraqi Patients with Coeliac Disease.

Background: Coeliac disease is a chronic, immunologically determined form of enteropathy affecting the small intestine in genetically predisposed children and adults. It is precipitated by the ingestion of gluten-containing foods. It is also referred to as celiac sprue, gluten-sensitive enteropathy, or nontropical sprue. CD69 is a lymphoid activation antigen whose rapid expression makes it suitable for the detection of T-ce

J Fac Med Baghdad

2014; Vol.56, No .2

Received Feb .2014

Accepted Apr. 2014

 
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Publication Date
Mon Dec 30 2013
Journal Name
Journal Of Genetic And Environmental Resources Conservation
Estimation of immunoglobulins levels in the sera of patients infected with liver hydatid cysts

This study included 46 patients with liver hydatid cyst diagnosed clinically and surgically, control group consist of 22 were naïve from infection had been confirmed by specialist. The patients were divided according to the size of the cysts into more and less than 5 cm diameter size, were 33 and 13 respectively. Also it divided into primary and secondary hydatid cyst infection which were 30 and 16 respectively. The role of immunological response against hydatid cyst parasite, showed a significant increased in humoral immunoglobulins (IgG, IgA, IgM and IgE) which were significantly higher in the hydatid cyst infection than control. Also significant increased in immunoglobulins in secondary infection than primary infection, beside significa

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Publication Date
Mon Jan 01 2018
Journal Name
Blood Research
Relationship between liver iron concentration determined by R2-MRI, serum ferritin, and liver enzymes in patients with thalassemia intermedia

4 Blood Res 2018;53:314-319. Received on August 11, 2018 Revised on August 30, 2018 Accepted on August 30, 2018 Background Iron overload is a risk factor affecting all patients with thalassemia intermedia (TI). We aimed to determine whether there is a relationship of serum ferritin (SF) and alanine ami- notransferase (ALT) with liver iron concentration (LIC) determined by R2 magnetic reso- nance imaging (R2-MRI), to estimate the most relevant degree of iron overload and best time to chelate in patients with TI. Methods In this cross-sectional study, 119 patients with TI (mean age years) were randomly se- lected and compared with 120 patients who had a diagnosis of thalassemia major (TM). Correlations of LIC, as determined by R2-MRI, with SF

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Publication Date
Thu Apr 27 2023
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Toxoplasmosis in females from Al-Anbar, Iraq: Human Female Toxoplasmosis

Background: Toxoplasmosis is a common zoonotic disease affecting one-third of the world population with potentially serious health implications.

Aim of the study: To find the prevalence and risk factors of Toxoplasma gondii infection among females in Al-Anbar, Iraq. 

Methodology: Over an eight-month period from (1st November 2021 to 30th June 2022), 200 females visiting private veterinary clinics in Al-Anbar (92 owned cats) participated in this prospective study. Age and residency were recorded. Blood samples were collected from all females and subjected first to the Toxoplasma Latex Agglutination test (TLAT). Samples of cat feces were collec

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