A newly developed analytical method characterized by its speed and sensitivity for the determination of metoclopramide hydrochloride (MCP-HCl) in pure and pharmaceutical preparation via turbidimetric measurement (0-180o) by Ayah 6SX1-T-2D Solar cell-CFI Analyser. The method was based on the reaction of phosphomolybdic acid with metoclopramide hydrochloride in acidic medium to form yellowish white precipitate for the ion-pair complex. Turbidity was measured via the reflection of incident light that collides on the surface precipitated particles at 0-180o. Chemical and physical parameters were studied and optimized. The calibration graph was linear in the range of 0.0005-3 or 0.0005- 4 mMol.L-1, with correlation coefficient r = 0.9947&0.9845 respectively. The limit of detection 3.543 ng/sample from the step wise dilution for the minimum concentration in the linear dynamic ranged of the calibration graph with RSD% lower than 0.3% for 1, 3 mMol.L-1 (n=8) concentration of metoclopramide hydrochloride . The method was successfully applied to the determination of metoclopramide hydrochloride in three pharmaceutical drugs. A comparison was made between the newly developed method analysis with the classical method (HANNA instrument for turbidity measurement) using the standard addition method via the use of t-test. It was noticed that there was no significant difference between two methods at 95 % confidence level.
This research involves an indirect Fluorophotometric method for the determination of microgram amount of oxymetazoline hydrochloride in the concentration range 0.1-5.0 g/ml. The method is based on the oxidation of the drug by cerium sulphate solution which is acidic medium where Ce IV is reduced to Ce III which can be excited at 259 nm to give an emitted light at 377 nm which is directly proportional to the concentration of Ce III which is equivalent to Ce IV that is needed to oxidize the studied drug. The average recovery of the method is 100.19% and relative standard deviation (RSD) < 0.37% . The method have been successfully applied to the determination of the studied drug in its pure and pharmaceutical preparations and it wa
... Show More
(2)
(3)
(14)
(11)
New membrane electrodes for determination of ciprofloxacin hydrochloride were prepared depending on ciprofloxacin hydrochloride - phosphotungstic acid (CFH-PT) as an active material and these electrodes were made with three plasticizers: Di-octylphenylphosphonate(DOPH), Di-butyl phosphate (DBP)Tri-n-butyl phosphate(TBP), in PVC matrix. One of the ciprofloxacin electrodes was gave Nernstian slope equal to 57.21 mV/ decade for DOPH membrane with concentration range from 1.5×10-5 to1.0×10-1 M, and detection limit equal to 1.5×10-6 M .Lifetime was 93 days. Non- Nernstian responses equal to 39.40 and 30.70 mV/ decade for membranes DBP, TBP, respectively. These electrodes were gave concentration range from 1.0× 10-5 to 1.0×10-2 and from 4.0
... Show More
(8)
A new spectrophotometric flow injection method has been establish for the determintaions of some catecholaminedrugs
A batch and flow injection (FI) spectrophotometric methods are described for the determination of barbituric acid in aqueous and urine samples. The method is based on the oxidative coupling reaction of barbituric acid with 4-aminoantipyrine and potassium iodate to form purple water soluble stable product at λ 510 nm. Good linearity for both methods was obtained ranging from 2 to 60 μg mL−1, 5–100 μg mL−1 for batch and FI techniques, respectively. The limit of detection (signal/noise = 3) of 0.45 μg mL−1 for batch method and 0.48 μg mL−1 for FI analysis was obtained. The proposed methods were applied successfully for the determination of barbituric acid in tap water, river water, and urine samples with good recoveries of 99.92
... Show More
(13)
(5)
The determination of manganese (II) using flow injection analysis with chemiluminescence detection was investigated. Mn2+ in sample solutions injected into a carrier stream of sodium bismuthate (NaBiO3) were oxidised to form MnO4- ions which were capable of producing luminescence after reaction with luminol/KOH in a flow cell. The linear range of the system is from 20 to 80 mg/L with a detection limit 8 mg/L. The proposed system is suitable for determination of Mn2+ in steel alloys after dissolution, filtration and dilution at a rate of approximately 60 samples per hour with a relative standard deviation (RSD)1.2%. Statistical comparison between the proposed system and standard spectrophotometric method revealed that there is no signific
... Show MoreThis piece of research work aims to study one of the most difficult reaction and determination due to continuous and rapid variation of reaction products and the reactants. As molybdenum (VI) aid in the decomposition of hydrogen peroxide in alkaline medium of ammomia, thus means a continuous liberation of oxygen which cuases and in a continuous manner a distraction in the measurement process. On this basis pyrogallol was used to absorbe all liberated oxygen and the result is an a clean undisturbed signals. Molybdenum (VI) was determined in the range of 4-100 ?g.ml-1 with percentage linearity of 99.8% or (4-300 ?g.ml-1 with 94.4%) while L.O.D. was 3.5 ?g.ml-1. Interferring ions (cations and anions) were studied and their main effect was red
... Show More
A simple, fast, and sensitive spectrophotometric method was suggested for the determination of Bromhexine Hydrochloride (BHH) in its pharmaceutical formulations. The method depends on the diazotization of BHH by sodium nitrite in acidic medium to produce the corresponding diazonium salt. The latter is coupled with phloroglucinol reagent in alkali medium to form a yellow water soluble azo-dye which has a maximum absorption at 405 nm with a molar absorptivity of 2.7×104 l.mol-1.cm-1 and Sandellʼs sensitivity of 0.01517 µg.cm-1. Beerʼs low is obeyed within a concentration range of 0.25-15 µg.mL-1 of BHH. The LOD and LOQ values of the proposed method were 0.087 µg.mL
(3)