Isradipine related to dihydropyridine (DHP) class of calcium channel blockers (CCBs). It is  used to treat hypertension, angina pectoris, as well as Parkinson disease. It goes under the BCS class II drug (low solubility-high permeability). The drug will experience extensive first-pass metabolism in liver, thus, oral bio-availability will be approximately15 to 24 %. 

       The aim of the study is preparing stable oral oil in water (o/w) nanoemulsion of isradipine to promote the colloidial dispersion of isradipine in the nano range, so that it may be absorded by intestinal lymphatic transport in order to avoid hepatic first-pass metabolism (israpidi

Many pharmaceutical molecules have solubility problems that until yet consist a hurdle that restricts their use in the pharmaceutical preparations. Lacidipine (LCDP) is a calcium-channel blocker with low aqueous solubility and bioavailability.

        Lipid dosage forms are attractive delivery systems for such hydrophobic drug molecules. Nanoemulsion (NE)  is one of the popular methods that has been used to solve the solubility problems of many drugs. LCDP was formulated as a NE utilizing triacetin as an oil phase, tween 80 and tween 60 as a surfactant and ethanol as a co-surfactant. Nine formulas were prepared, and different tests performed to ensure the stability of the NEs, such as thermodyna

     This study aims to determine the exposure of dentists to radiation resulting from the use of light therapy units and to assess their risk and impact on dental clinics.  This study was conducted in private dental clinics in the city of Erbil in northern Iraq. Surveys were conducted to collect information about light-curing units. The results were analysed using the multi-response logistic regression to determine the factors affecting the radiation values of light-curing units. The results of the study showed that five major variables have a major effect by radiation.  This is shown with a value of P ≤ 0.05. Typical treatment times with radiant light, with a typical number of daily restorations, may exceed the risk limits for

The ionospheric characteristics exhibit significant variations with the solar cycle, geomagnetic conditions, seasons, latitudes and even local time. Representation of this research focused on global distribution of electron (Te) and ion temperatures (Ti) during great and severe geomagnetic storms (GMS), their daily and seasonally variation for years (2001-2013), variations of electron and ion temperature during GMS with plasma velocity and geographic latitudes. Finally comparison between observed and predicted Te and Ti get from IRI model during the two kinds of storm selected. Data from satellite Defense Meteorological Satellite Program (DMSP) 850 km altitude are taken for Te, Ti and plasma velocity for different latitudes during great

Antacids have been widely used in the treatment of various gastric and duodenal disorders such as heartburn, reflux esophagitis, gastritis, irritable stomach, gastric and duodenal ulcers. A pH-responsive of bi-polymer of sodium alginate and pectin have been studied as raft-forming polymers using sodium bicarbonate and calcium carbonate as gas-generating and calcium ion sources. The aim of study was to formulate and evaluate mono and bilayer tablets of floating and sustained release antacid delivery systems using sodium carboxy methyl cellulose as a gel forming substance, calcium and magnesium carbonate as sources of acid neutralizing and carbon dioxide gas generators agents upon contact with acidic solution. The effect of the formulation

In this paper, we present an approximate method for solving integro-differential equations of multi-fractional order by using the variational iteration method.
First, we derive the variational iteration formula related to the considered problem, then prove its convergence to the exact solution. Also we give some illustrative examples of linear and nonlinear equations.

The huge amount of information in the internet makes rapid need of text
summarization. Text summarization is the process of selecting important sentences
from documents with keeping the main idea of the original documents. This paper
proposes a method depends on Technique for Order of Preference by Similarity to
Ideal Solution (TOPSIS). The first step in our model is based on extracting seven
features for each sentence in the documents set. Multiple Linear Regression (MLR)
is then used to assign a weight for the selected features. Then TOPSIS method
applied to rank the sentences. The sentences with high scores will be selected to be
included in the generated summary. The proposed model is evaluated using dataset

   Real life scheduling problems require the decision maker to consider a number of criteria before arriving at any decision. In this paper, we consider the multi-criteria scheduling problem of n jobs on single machine to minimize a function of five criteria denoted by total completion times (∑), total tardiness (∑), total earliness (∑), maximum tardiness () and maximum earliness (). The single machine total tardiness problem and total earliness problem are already NP-hard, so the considered problem is strongly NP-hard.

We apply two local search algorithms (LSAs) descent method (DM) and simulated annealing method (SM) for the 1// (∑∑∑

      Internet of Vehicle (IoV) is one of the most basic branches of the Internet of Things (IoT), which provides many advantages for drivers and passengers to ensure safety and traffic efficiency. Most IoV applications are delay-sensitive and require resources for data storage and computation that cannot be afforded by vehicles. Thus, such tasks are always offloaded to more powerful nodes, like cloud or fog. Vehicular Fog Computing (VFC), which extends cloud computing and brings resources closer to the edge of the network, has the potential to reduce both traffic congestion and load on the cloud. Resources management and allocation process is very critical for satisfying both user and provider needs. However, th