Introduction and Aim: Beta-thalassemia is a serious inherited genetic disorder and an increasing health burden globally. Beta -thalassemia is caused by genetic globin abnormalities within the hemoglobin beta (HBB) gene. This study aimed to characterize the HBB gene mutations in beta -thalassemia among southern Iraqi patients. Materials and Methods: The study included 30 beta -thalassemia patients referred to the Thi-Qar Center for Genetic Diseases, Iraq and 15 control samples from a random group of apparently healthy individuals. Genomic DNA was isolated from blood sample collected from each individual. The DNA was amplified for specific regions of the HBB gene and the amplified products sequenced. The sequences generated were analysed for mutations using sequence analysis tools. Results: Molecular analysis revealed several mutations in the HBB gene including translocation, deletion and substitution mutations in the population tested positive for the beta -thalassemia trait. Conclusion: Thalassemia major is a serious concern in southern Iraq and therefore this study emphasizes a need for complete mutation profiling of the beta -globin gene as a strategy for screening of carriers within the population. Such examinations could be useful in pre-marital genetic counseling and for undertaking prevention and treatment measures.
Type 2 diabetes mellitus (T2DM) is a chronic disorder that is a serious health concern all over the globe, it is linked to Interleukin-10 (IL-10) single nucleotide polymorphisms (SNPs) at the promoter region. On the other hand, diabetes influences the cellular and humoral immunity predisposing the patient to a variety of opportunistic parasites one of them is Toxoplasma gondii (T. gondii), which may infect any nucleated cell, including pancreatic cells. The purpose of this research was to explore the association of IL-10 genetic polymorphisms with T2DM and latent toxoplasmosis among Iraqi patients with T2DM. Fifty-five and fifty-eight venous blood samples were taken from T2DM patients and age-matched non-diabetic person
... Show MoreBackground: There is a significant molecular response to imatinib given at standard doses in individuals with chronic myeloid leukemia (CML) whose ABCB1 polymorphisms are present. Objective: To investigate the impact of the polymorphism in the ABCB1 gene rs1128503 on the effectiveness of nilotinib or imatinib therapy. Methods: From May 2022 until the end of January 2023, the current study was carried out in a single research institution, the National Center of Hematology, Baghdad Teaching Hospital at Medical City, Iraq. 76 people with chronic phase myeloid leukemia (CML-CP), who had previously received a diagnosis using the European Leukemia Net (ELN) criteria, enrolled in the trial. The PCR product was delivered to Macrogen Corpora
... Show MoreOil recovery could be impacted by the relation between vertical permeability (Kv) and horizontal permeability (Kh) (Kv/Kh). 4816 plugs that have been getting hold of 18 wells of Mishrif formation in the West Qurna oilfield were used. Kv/Kh data provided some scatter, but the mean is ~1. Kv/Kh =1 was used for the Petrel model before upscaling according to the heterogeneity of each layer.
Kv/Kh values for Mishrif Formation in West Qurna Oilfield are 0.8 for relatively homogeneous, 0.4 for heterogeneous rock, and 0.1 for cap rocks (CRII).
Eclipse TM was used for reservoir simulation. PVT and SCAL data e
... Show MoreThe present study was implemented in the period from January to December 2017, to assess the assemblage of fish, with the effects of some environmental factors and knowledge the impacts of annual periodic fluctuations between drowning and drought on the abundance and size-spectrum on the fish community in Al-Cibyaish marsh. Water temperature ranged between 13 ͦ C in January to 35 ͦ C in July, salinity from 2.90 PSU (Practical salinity unite) in February to 4.14 PSU in August. Hydrogen ion ranged between 7.60 in July to 8.30 in February. The present study appears contribution of environmental variables in the distribution, widespread and occurrence of fish assemblage in the Al-Chibyaish marsh. A total of 3294 specimens were collected re
... Show MoreThe carbonate ramp facies of the Late Albian-Early Cenomanian Mauddud Formation were studied in the Ratawi Oilfield, Basra Governorate, south of Iraq using integrated borehole data set that included, core and cutting samples in three drilled wells to analyze the petrography of the Mauddud Formation, two hundred and eighty-one (281) thin sections were prepared and examined for the three selected wells. The results show that the formation is composed of light grey dolomitized limestone and pseudo-oolitic creamy limestone with green to bluish shale. The petrographic observations results show four facies’ associations in the Mauddud Formation. These include: Mid–Ramp environment which is represented by Argillaceous mudstone mi
... Show MoreThe Nahr Umr Formation, one of the most important Cretaceous formations and one of the main generating reservoirs in southern Iraq and neighboring regions, was chosen to study and estimate its petrophysical properties using core plugs, lithofacies, and well logs from five wells in the Noor oilfield. Reservoir properties and facies analyses are used to divide the Nahr Umr formation into two-member (limestone in the upper part and main sandstone in the lower). Limestone members are characterized by low reservoir properties related to low effective porosity and permeability while the main sandstone member is considered as a reservoir. Four lithofacies were recognized in the main sandstone member of the Nahr Umr Formation according to petrog
... Show MoreThe 2-D Resistivity imaging survey conducted within the desert area to meet the region's need of groundwater, due to the absence of any surface water, in addition, there are no any geophysical studies carried out previously. Ten point survey was performed to study the ground water aquifers in the southwest of Samawah city, Iraq. The length of the survey line in each point survey is 1200 meters by using 120 electrodes with 10 meters electrode spacing by applying Wenner-Schlumberger array. There are three main resistivity zones in the study area. The first resistivity zone ranging between 2.00-10.1 ohm.m, locate at shallow depth, represented Quaternary deposits. The second resistivity zone ranging between 22.8-51.3 ohm.m, it represents bea
... Show MoreObjective: The aim of the study was to estimate the action atorvastatin(20mg/day) on bone biochemical markers dyslipidemic men. Methodology: This study was conducted between May 2015 and November 2015 in Al-Basrah General hospital in Basra, Iraq, to evaluate important role of atorvastatin (20mg/day)(Lipitor® Pfizer Pharma GmbH.Germany) on bone biochemical markers. Thirty men patients who had been admitted for a variety of medical problems included in the study. All the patients had previously been diagnosed with Dyslipidemia by specialist physician in internal medicine and all patients age below 55 yea