Excess alcohol consumption is associated with numerous metabolic changes and homeostasis disturbances of many macro- and micro-elements in the body. It has been associated with multiple pathologies at all levels. In the digestive apparatus, alcohol has generally been related to its toxic effects upon the liver. Alpha-1 antitrypsin (α-1 AT or AAT) plays an important role in controlling inflammation, coagulation and repair mechanisms in the body and most α-1 AT in the body is produced by the liver; from the other hand, Intrinsic factor (IF), which is a glycoprotein produced by the parietal cells of the stomach is necessary for the absorption of vitamin B12 in the small intestine. This study was designed to assess serum levels of α-1 AT and anti-IF Abs (IgG) among heavy alcoholics to clarify the relationship between alcohol addiction and such liver and/or stomach disorders. Fifty-four consecutive alcohol-dependent males were enrolled as a target group and 30 age matched males were considerate as a control group. The level of alpha-1 antitrypsin (α-1 AT) and anti-intrinsic factor (IF) antibodies were investigated by single radial immunodiffusion (SRID) and enzyme-linked immunosorbent assay (ELISA) respectively. We found from a total of 54 alcoholic patients that the mean age of patients is 37.5 years with a progressive increase in cases at third decade of age. They reported an average addiction period of more than 18 years. Most patients (93%) were currently smoking; and 18.5% were psychiatric; about 9% of them used to have co-addictions like heroin, valium and artin; another 9% had multiple sclerosis. We observed a non significant decrease of α-1 AT levels in alcoholics compared to control group (p>0.05), while there was a high significant increase in the level of anti-IF Abs in alcoholics, sera compared with control group (p<0.05). Furthermore; the serum level of α-1 AT and anti-IF Abs in alcoholic group are not related to age of starting consumption of alcohol. Specifically, we found no significant differences in the levels of α-1 AT and anti-IF Abs between those who start drinking prior to age 18 years (N=32), and after age 18 years (N=22) p>0.05. On the other hand; there is a statistically significant correlation between α-1 AT levels and the duration of alcohol consumption (p<0.05); similarly; theere was a highly significant correlation between the levels of anti-IF Abs and the duration of alcohol consumption was observed (p<0.05).The results suggest that Excess alcohol consumption is associated with numerous metabolic changes and homeostasis disturbancesof many macro- and micro-elements in the body. It has been associated with multiple pathologies at all levels.
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The study involved 45 male and 45 females of diabetic patients type- ?? aged from 40-69years , and with the same numbers of males and females for control , all the patients and controls were without any periodontal diseases and without any systemic disease. Diabetic patients were divided in to three groups according to the degree of periodontitis , and the inflamed gingiva of all groups of diabetic patients were treated with the dried fruits powder (crude) of medicinal plants Quercus robur , Thuja occidenalis , Terminalia chebula, Anethum graveolens , respectively and mixture. Some immunological and antimicrobial factors (IgA, Lactoferrin , Lysozyme ) , were detected in serum and saliva of diabetic patients and the control
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Several symptoms of hypothyroidism characterized by low
FT3 and FT4 were classified into hypothyroidism and Hoffman's syndrome .It was accepted that free radical generation and lipid peroxidation are associated with many diseases. Creatine kinase in serum is affected by thyroid hormones. This study was undertaken to investigate the relationship between malondialdehyde as a general lipid peroxidation marker and CK activity in patients with primary hypothyroidism and Hoffman's syndrome which indicatees hypothyroidism with undetectable FT3 and FT4 in serum with elevated values of TSH.
The study revealed that MDA is within the normal range, while CK activities in sera of Hoffman's syndrome were increas
... Show MoreBackground: Most primary hypothyroidism patients also experience inefficiency and irregularity. It is possible to understand the significance of myo-inositol in treating the thyroid gland by relating it to the synthesis of thyroid hormones. Study aimed to estimate serum of inositol 1,4,5-triphosphate (IP3) in primary hypothyroidism disorder and through that level it can shed light on whether it is accused of inactivity of the thyroid gland and at the same time open the doors for the use as a treatment.
Subject and Methods: The study was taken from the analytical cross-sectional design.120 subjects were divided into three groups, the first group included 40 healthy subjects, the s
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The experiment was conducted using Potato( Solanum tuberosum L.) at the eastern Radwaniyah at private field during fall season 2020/2021 and spring 2021 to study the effect of nitrogen levels to 350, 275, 200 kg N h-1 ( N1, N2, N3) and phosphorous to 100, 180, 360 kg P2O5 h-1 ( P1, P2, P3) and potassium to 100, 200, 300 kg K2O h-1 ( K1, K2, K3) to vegetative growth and yield of industrial potato, The seeds of the hybrid potato Sinora, Class A, were planted in the fall season on 15/9/2020 and Elite in the spring season on 31/1/2021. The experimental fertilizers were added in four batches and in proportions according to the stages of plant age, Factorial experiment with RCBD using three replications. The results showed that changing t
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Sliver / Sliver chloride is as old used from human but the sliver / sliver chloride nanoparticles have only recently been recogenized. They have used in medicin and agiculture. In the present study have been investigation the effecte biosynthesis Sliver / Sliver chloride nanoparticles as antibacterial by demonstrated that Ag / AgCl NPs arrest the growth of many bacterial: S.typhimurium, k. pneumonia. S. aureus, L.monocytogenes, B. Anthracis, E. coli, C. frundi, S. Pneumonia, P. Aeruginosa. The elements compestion and crystallization panal of biosynthesized nanoparticles were chracterazated by FTIR, XRD and SEM. From XRD, It is confirmed the synthesized nanoparticles contain Sliver / Sliver chloride elements. Synthesized Ag / AgCl NPs showed
... Show MoreAbstract: Chalcones were used to synthesis series of 2-pyrazoline derivatives and evaluated their antimicrobial and anti-inflammatory activities (E)-1,3-diphenylprop-2-en-1-one (1-5) were synthesized by Claisen-Schmidt Condensation method through the reaction of acetophenone with five various para substituted benzaldehyde in presence of KOH, the reaction monitoring by TLC and the result intermediates were checked by melting point and FT-IR Various 2-Pyrazoline derivatives were prepared by one pot reaction that involved the refluxing of (E)-1,3-diphenylprop-2-en-1-one (1–5) and Hydrazine monohydrate in the presence of glacial acetic acid for 24 hours at a temperature of (45–50) °C fo
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Direct determination of trace metals Zn, Mn, Cu and Co were performed in serum
blood samples of two groups diabetic patient type 2 and non diabetes by ICP spectrometric
method. Results show the low levels of these elements Zn, Mn and Co while high level of Cu
detected compared with non diabetes according to these results good evidence can be made to
control these levels through a special diet containing these metals.
There are many harmful acts that occur from drunkards in this case, especially those resulting from car accidents. The world is witnessing dozens or even hundreds of car accidents due to alcohol consumption. These accidents often result in serious injuries that could lead to the death of the drunk driver and those in the car As well as other persons present in the other vehicles with which the incident occurred or pedestrians on the street, as well as damage to private or public property, and if the order of return of the affected persons on the pretext of civil liability (tort) is made as a direct cause of the harmful act, Is entitled Do they like this refer to the liquor seller or their provider as the culprit? Or are they not related to
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