ﺔﻴﻋﺍﺫﻹﺍ ﺕﺎﻴﻨﻘﺘﻟﺍ ﻡﺍﺪﺨﺘﺳﺍ ﰲ ﲑﺒﻛ ﺭﻮﻄﺗ ﻦﻣ ﻝﺎﺼﺗﻻﺍ ﺮﺼﻋ ﻩﺪﻬﺷ ﻱﺬﻟﺍ ﺖﻗﻮﻟﺍ ﰲ ﺔﻴﻧﻮﻳﺰﻔﻠﺘﻟﺍﻭ ﺍ ﺢﺴﻓ ﰲ ﻢﻬﺳﺃ ﺕﺎﻄﶈﺍ ﺀﺍﻮﺳ ﺔﻴﻧﻮﻳﺰﻔﻠﺘﻟﺍ ﺕﺍﻮﻨﻘﻟﺍ ﺚﺒﻟ ﻊﺳﺍﻮﻟﺍ ﻝﺎ ( ﺔﻴﺿﺭﻷﺍ ﺔﻴﻠﺑﺎﻜﻟﺍ ﻭﺃ ﺔﻴﺋﺎﻀﻔﻟﺍ ﻭﺃ ( ﱵﻟﺍ ﺔﺻﺎﳋﺍ ﺔﻴﺋﺎﻀﻔﻟﺍ ﺕﺍﻮﻨﻘﻟﺍ ﻦﻣ ﺪﻳﺪﻌﻟﺍ ﺭﻮﻬﻇ ﰲ ﺎﻀﻳﺃ ﺪﻋﺎﺳ ﺎﳑﻭ ، ﺕﺎﻴﺋﺎﻀﻔﻟﺍ ﺭﻮﻬﻇ ﻚﻟﺫ ﻞﺒﻗ ﺩﺎﺳ ﻥﺃ ﺪﻌﺑ ﺔﻴﻣﻮﻜﺣ ﲑﻏ ﺕﺎﻴﻌﲨ ﻭﺃ ﺕﺎﻤﻈﻨﻣ ﻭﺃ ﺩﺍﺮﻓﺃ ﺎﻬﻜﻠﺘﳝ ﻟ ﺔﺠﻴﺘﻧﻭ ،ﺔﻟﻭﺪﻟﺍ ﺎﻬﻜﻠﺘﲤ ﱵﻟﺍ ﻪﺗﺪﻬﺷ ﻱﺬﻟﺍ ﻲﻣﻼﻋﻹﺍ ﺡﺎﺘﻔﻧﻻﺍ ﱪﻋ ﻕﺍﺮﻌﻟﺍ ﺎ ﺮﻣ ﱵﻟﺍ ﻑﻭﺮﻈﻠ ﺹﺎﺧ ﻞﻜﺸﺑ ﺔﻴﺋﺎﻀﻔﻟﺍ ﺕﺍﻮﻨﻘﻟﺍﻭ ،ﺔﻣﺎﻋ ﺓﺭﻮﺼﺑ ﻡﻼﻋﻹﺍ ﻞﺋﺎﺳﻭ ﻊﻴﲨ ) ﺔﻴﻗﺍﺮﻌﻟﺍ– ﺔﻴﻗﺮﺸﻟﺍ – ﺔﻳﺮﻣﻮﺴﻟﺍ– ﺭﺎﻳﺪﻟﺍ – ﺀﺎﺤﻴﻔﻟﺍ –ﺕﺍﺮﻔﻟﺍ – ﺭﺍﻮﻧﻷﺍ-(.. ﺪﻗ ﺕﺎﻴﺋﺎﻀﻔﻟﺍ ﻩﺬﻫ ﺭﻮﻬﻇ ﻥﺇ ﻭ ، ﺎﳘ ﲔﻤﻬﻣ ﻦﻳﺭﻮﳏ ﺭﺎﺛﺃ . . : ١-ﻴﻛﺄﺘﺑ ﻖﻠﻌﺘﻳ ﻡﻼﻋﻹﺍ ﻝﺎﳎ ﰲ ﺭﺎﻤﺜﺘﺳﻻﺍﻭ ﻊﻤﺘﺍ ﰲ ﺹﺎﳋﺍ ﻉﺎﻄﻘﻟﺍ ﺭﻭﺩ ﺪ . ٢-ﺕﺍﻮﻨﻘﻟﺍ ﻚﻠﺗ ﻦﻋ ﺭﺩﺎﺻ ﻮﻫ ﻲﻣﻼﻋﺇ ﺏﺎﻄﺧ ﺔﺣﺎﺗﺇ ﻯﺪﻣﻭ ﺔﺣﻮﻨﻤﳌﺍ ﺔﻳﺮﳊﺍ ﻢﺠﺣ . ﺎﻴﻣﻼﻋﺇ ﺎﻄﳕ ﺖﲰﺭ ﺪﻗ ﻕﺍﺮﻌﻟﺍ ﰲ ﺕﺎﻴﺋﺎﻀﻔﻟﺍ ﻩﺬﻫ ﺭﻮﻬﻇ ﻥﺇ ،ﻕﺎﻴﺴﻟﺍ ﺍﺬﻫ ﰲﻭ ﻥﻻﺃ ﺪﻌﺑ ﻦﻜﻳ ﱂ ﻡﻼﻋﻹﺍ ﻥﺇ ﻮﻫﻭ ،ﺎﻘﺑﺎﺳ ﻕﺍﺮﻌﻟﺍ ﻩﺪﻬﺸﻳ ﱂ ﺎﺻﺎﺧ ﻭﺃ ﺎﻬﺟﻮﻣ ﻭﺃ ﺎﻴﲰﺭ ﺎﻣﻼﻋﺇ ﲑﻴﻐﺘﻟﺍ ﺪﻌﺑ ﻢﻬﺘﺒﻟﺎﻄﻣ ﻞﺑ ﺕﺍﻮﻨﻘﻟﺍ ﻚﻠﺗ ﺏﺎﺤﺻﺃ ﻡﺎﻤﺘﻫﺍ ،ﻚﻟﺫ ﺐﻧﺎﺟ ﱃﺇ ،ﺔﻟﻭﺪﻠﻟ ﺎﻛﻮﻠﳑ ﺙﺍﺪﺣﺃ ﺪﻌﺑ ﺪﻠﺒﻟﺍ ﻩﺪﻬﺷ ﻱﺬﻟﺍ ﻲﺳﺎﻴﺴﻟﺍ ٩ / ٤ / ٢٠٠٣ ﺏﺎﻄﳋﺍ ﰲ ﺔﻳﺮﺣ ﻚﻟﺎﻨﻫ ﻥﻮﻜﺗ ﻥﺄﺑ، ﺪﻴﻛﺄﺗﻭ ﺔﻴﻟﻭﺪﻟﺍ ﻥﺎﺴﻧﻹﺍ ﻕﻮﻘﺣ ﺉﺩﺎﺒﻣ ﻦﻣ ﺎﻗﻼﻄﻧﺍ ﺔﻴﻣﻮﻜﳊﺍ ﲑﻏ ﺕﺎﻋﺎﻄﻘﻟﺍ ﱪﻋ ﻲﻣﻼﻋﻹﺍ ﺔﺻﺎﺧ ﺔﻴﻧﻮﻳﺰﻔﻠﺗ ﺕﺍﻮﻨﻗ ﺀﺎﺸﻧﺈﺑ ﺕﻼﻴﻬﺴﺘﻟﺍﻭ ﺹﺮﻔﻟﺍ ﻊﻴﲨ ﺔﺣﺎﺗﺇ ﱪﻋ ﲑﺒﻌﺘﻟﺍﻭ ﻱﺃﺮﻟﺍ ﺔﻳﺮﺣ ﺔﻴﲰﺮﻟﺍ ﺕﺎﺣﻭﺮﻄﻟﺍ ﻦﻋ ﻒﻠﺘﲣ ﺕﺎﺣﻭﺮﻃﻭ ﺮﻈﻧ ﺕﺎﻬﺟﻭ ﻞﻤﲢ .
Atorvastatin calcium (ATR) is an antihyperlipidemic agent used for lowering blood cholesterol levels. However, it is very slightly soluble in water with poor oral bioavailability, which interferes with its therapeutic action. It is classified as a class II drug according to Biopharmaceutical Classification System (low solubility and high permeability).