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Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

Activation of farnesoid X receptor (FXR) markedly attenuates development of atherosclerosis in animal models. However, the underlying mechanism is not well elucidated. Here, we show that the FXR agonist, obeticholic acid (OCA), increases fecal cholesterol excretion and macrophage reverse cholesterol transport (RCT) dependent on activation of hepatic FXR. OCA does not increase biliary cholesterol secretion, but inhibits intestinal cholesterol absorption. OCA markedly inhibits hepatic cholesterol 7α‐hydroxylase (Cyp7a1) and sterol 12α‐hydroxylase (Cyp8b1) partly through inducing small heterodimer partner, leading to reduced bile acid pool size and altered bile acid composition, with the α/β‐muricholic acid proportion in bile increased by 2.6‐fold and taurocholic acid (TCA) level reduced by 71%. Overexpression of Cyp8b1 or concurrent overexpression of Cyp7a1 and Cyp8b1 normalizes TCA level, bile acid composition, and intestinal cholesterol absorption. Conclusion: Activation of FXR inhibits intestinal cholesterol absorption by modulation of bile acid pool size and composition, thus leading to increased RCT. Targeting hepatic FXR and/or bile acids may be useful for boosting RCT and preventing the development of atherosclerosis. (Hepatology 2016;64:1072‐1085)

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Publication Date
Mon Mar 08 2021
Journal Name
Baghdad Science Journal
Preparation and identification of oxidatin derivaties for Salts and acids of bile for medical uses

The purified prepared compounds were identified through different methods of identification i.e, I.R, UV-vi^ble-spectroscopy in addition to (coloured tests) Calculation of the sum of OH groups. TLC techniques were also used to test the purity and the speed ofthe rate of flow (RF).

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Publication Date
Fri Feb 28 2020
Journal Name
Neuroquantology
Using X-Ray Films for Evaluation efficiency of Unsaturated Polyester Reinforced by Lead Oxide as Shielding for Medical X-ray Devices

The largest use of x-ray in medical by dentists, employers or persons that needed by patients with specific conditions, lead to higher exposure of x-ray that may cause many diseases. In the present work radiography films have been used in evaluating the efficiency of using unsaturated polyester polymer reinforced with lead oxide (PbO) as shield material for medical x-ray devices, many parameters studied like concentration and thickness that they are increasing the attenuation of x-ray in them. The results show that the attenuation of X-ray increasing with concentration of reinforced material and with thickness, and the optical density decreases with increasing concentration from 0% to 50%, we chose 30% as suitable concentration to increase

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Publication Date
Tue Dec 14 2010
Journal Name
Applied Microbiology And Biotechnology
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Publication Date
Wed Oct 01 2014
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Management of Obstractive Jaundice Due to Common Bile Duct Stone in Baghdad Teaching Hospital.

Background: the most common cause of obstructive jaundice is CBD stones, and these can produce significant morbidity and mortality. The management of the obstructive jaundice due to CBD stones is in evolution; several methods of investigations and treatment have been introduced, and each one has its own advantages and disadvantages.

Objective: to study and evaluate the management of obstructive jaundice due to CBD stones in Baghdad teaching hospital.

Results: from the 125 patients presented with obstructive jaundice included in this study 14 patients were found to have a periampullary lesions, and they were excluded from the study, so the total number of the patients was

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Publication Date
Tue Apr 01 2008
Journal Name
Journal Of The Faculty Of Medicine Baghdad
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Publication Date
Sun Oct 22 2023
Journal Name
Iraqi Journal Of Science
Reverse Derivations With Invertible Values

In this paper, we will prove the following theorem, Let R be a ring with 1 having
a reverse derivation d ≠ 0 such that, for each x R, either d(x) = 0 or d(x) is
invertible in R, then R must be one of the following: (i) a division ring D, (ii) D 2 ,
the ring of 2×2 matrices over D, (iii) D[x]/(x ) 2
where char D = 2, d (D) = 0 and
d(x) = 1 + ax for some a in the center Z of D. Furthermore, if 2R ≠ 0 then R = D 2 is
possible if and only if D does not contain all quadratic extensions of Z, the center of
D.

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Publication Date
Sun Jul 02 2023
Journal Name
Iraqi Journal Of Science
Reverse Derivations With Invertible Values

this paper, we will prove the following theorem, Let R be a ring with 1 having
a reverse derivation d ≠ 0 such that, for each x R, either d(x) = 0 or d(x) is
invertible in R, then R must be one of the following: (i) a division ring D, (ii) D 2 ,
the ring of 2×2 matrices over D, (iii) D[x]/(x ) 2
where char D = 2, d (D) = 0 and
d(x) = 1 + ax for some a in the center Z of D. Furthermore, if 2R ≠ 0 then R = D 2 is
possible if and only if D does not contain all quadratic extensions of Z, the center of
D.

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Publication Date
Fri Jan 26 2024
Journal Name
Iraqi Journal Of Science
Reverse *-Centralizers on *-Lie Ideals

The purpose of this paper is to prove the following result : Let R be a 2-torsion free prime *-ring , U a square closed *-Lie ideal, and let T: RR be an additive mapping. Suppose that 3T(xyx) = T(x) y*x* + x*T(y)x* + x*y*T(x) and x*T(xy+yx)x* = x*T(y)x*2 + x*2T(y)x* holds for all pairs x, y  U , and T(u) U, for all uU, then T is a reverse *-centralizer.

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Publication Date
Sun Sep 05 2010
Journal Name
Baghdad Science Journal
Composition operator induced by ?(z) = sz + t for which |s|?1, |t|<1 and |s|+|t|?1

We study in this paper the composition operator that is induced by ?(z) = sz + t. We give a characterization of the adjoint of composiotion operators generated by self-maps of the unit ball of form ?(z) = sz + t for which |s|?1, |t|<1 and |s|+|t|?1. In fact we prove that the adjoint is a product of toeplitz operators and composition operator. Also, we have studied the compactness of C? and give some other partial results.

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Publication Date
Sat Dec 01 2018
Journal Name
Al-khwarizmi Engineering Journal
Classical and Statistical Optimization of Medium Composition for Promoting Prodigiosin Produced by Local Isolate of Serratia Marcescens

Prodigiosin is a ‘natural red pigment produced by Serratia marcescens which exhibits immunosuppressive and anticancer properties in addition to antimicrobial activities. This work presents an attempt to maximize the production of prodigiosin by two different strategies: one factor at time (OFAT) and statistical optimization. The result of OFAT revealed that sucrose and peptone were the best carbon and nitrogen sources for pigment production with concentration of prodigiosin of about 135 mg/ L. This value was increased to 331.6mg/ L with an optimized ratio of C/N (60:40) and reached 356.8 with pH 6 and 2% inoculum size at end of classical optimization. Statistical experimental design based on Response surface methodology was co

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