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Synthesis and biological activity of new esters derived from D-fructose-containing isoxazole moiety
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Background: Isoxazoles are an important class of five-membered unsaturated heterocyclic compounds. They show several applications in diverse areas such as pharmaceuticals, agrochemistry and industry. Isoxazoles are also found in natural sources showing insecticidal, plant growth regulation and pigment functions. Current study was conducted for synthesis of twenty five new Isoxazole derivatives and to evaluate the in vitro antibacterial activities of these derivatives. Methods: Benzaldoxime and their substituted [I] ae were prepared via addition-elimination reactions between aromatic aldehyde and hydroxylamine hydrochloride. In a second step, para-or meta-substituted benzaldoximes [I] ae were reacted with N-chlorosucceinimide in DMF to yield the para-or meta-substituted benzhydroxamic chlorides [II] ae. On the other hand D-fructose was converted to 2, 3: 4, 5-di-O-isopropylidene-D-fructopyranose [III] using dry acetone and sulfuric acid as a catalyst. Results and Conclusions: The reaction of compound [III] with propargyl bromide in DMF yielded the terminal alkyne [IV]. The esterification reaction of hydroxyl groups of compounds [VI] ae with different acid chloride in mixture THF and DMF using triethylamine as a catalyst give new compounds [VII] ae,[VIII] ae and [IX] ae. All synthesized compounds were identified by FTIR and most of them were characterized by 1H NMR, 13C NMR, and HRMS. Also the synthesized compounds showed variable antimicrobial activities in vitro against Escherichia coli, Bacillus substilis,

Publication Date
Mon Sep 18 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Estimation of Ceruloplasmin activity, and copper, iron levels in ·sera of nor1nal pregnants
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This  study  was undertaken  to shed light on the changes  of levels of CP

activity, Cu and  Fe in sera of .(53) normaJ non-smoker pregnant's  without complication, during  three1rimestcrs of pregnancy.

G1  inc.l_ude  (I 8) pre nants in  the 1' 1 tri nester, G2 19)  pret:,rp:all.ts  _wear

taken     m the  2"    tnmester  and  G3  (16) pregnants  m the  3rd  trunester.

/\nothe.r ('18) ·serum samples were taken from liealthy non-pregnant wqmen

age matched as control·group G4.

Results bowed a significant steady  elevation in CP .p:ctivity and &n

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Publication Date
Wed Nov 02 2022
Journal Name
Neuroquantology
Inhibition activity of mucilage prepared of Salvia hispanica as anti filamentary and anticancer
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An International Publisher for Academic and Scientific Journals The mucilage of white and black chia seeds were extracted and determining their contents of bioactive compounds such as tannins, glycosides, flavonoids, phenols, and studying their activity as anti-filamentary and anticancer. Results showed that tannins exist in white chia seeds with 35%while it is 38% in black seeds, flavonoids represent 0.98mg/ml in white chia seeds and 1.5 mg/ml for black seeds. Both kinds of seeds showed anti-filamentaryactivity, the inhibition ratio was 86.5% for white seeds and 97.3% for black seeds. Chia black seeds showed anticancer activity and the inhibition of the tumor muscle cell line ratio (GI%) was 34.8% at 50mg/ml concentration and 88.4%

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Publication Date
Thu Oct 01 2020
Journal Name
Systematic Reviews In Pharmacy
Estimation of activity and toxicity of silver nanoparticles loaded metronidazole against Giardia lamblia
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Giardia lamblia is one of most common protozoan cause diarrheas, and the most health problem in development countries worldwide. Our work aimed to assess activity and toxicity of metronidazole loaded silver nanoparticles in treatment of acute giardiasis in mice. After inoculated mice with Giardia cysts in a dose of 105 cyst for acute infection, treatments were given for eight days. Number Giardia cysts in stool were discovered. Toxicity nanoparticles was estimated by Measurement oxidative stress markers (GSH) and (MDA) in liver, kidney tissue homogenate. The results showed single therapy was better effect by silver nanoparticles, highest percentages of reduction in number of cysts Giardia lamblia of infected mice treated with silver nanopar

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Scopus
Publication Date
Wed Jun 28 2017
Journal Name
Iraqi Journal Of Science
Antibacterial Activity of Synergistic Effect of Colicin and Gold Nanoparticles Against Pseudomonas Aerugensa
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Publication Date
Mon Dec 25 2017
Journal Name
Oriental Journal Of Physical Sciences
Evaluating a Chemical/Biological Laboratory to Promote Safety Measures
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The Department of Chemical and Biological Engineering, Al-Khwarizmi College of Engineering at Baghdad University has lately renovated its own research laboratories to comply with international safety measures and conduct undergraduate and postgraduate research. In this regard, the department has harnessed some amenities within the college to establish these laboratories taking into accounts creating a convenient, safe, and developed working environment for both researchers and students. A precise procedure was followed to establish this laboratory which includes providing new bench tops which offer spacious working places for workers. These benches were supplied with power points, gas, water, and compressed air outlets. In addition,

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Publication Date
Thu Nov 09 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Platelet Activity And Some Immunological Findings In Atherosclerosis and Coronary Heart Disease
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The   platelet  activity  and  some  immunological  aspects  of

coronary heart disease CIID were investigated by employing platelet count and serum levels of IgG,IgM and lgA,C3 and C4.Three groups of  patients were investigated : patients with ischemic heart disease IHD,  patients  with      lliD+hypcrtension  and  patients  with IHD+unstable angina.The results revealed  that the mean of platelets (mm')  was  significantly  reduced   in  IHD+unstable  angina  group

2.72.L I.l2 compared with conrol b'TOUp 8.13±2.72.

With respect to the immunological study, the re;;ults revea

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Publication Date
Thu Sep 27 2018
Journal Name
Journal Of The College Of Education For Women
Some urban structures of the city of Baghdad in the book almntadham Ibn al-Jawzi (d. 597 e)
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 We conclude that this study has dealt with an important aspect of the book that was not clearly defined in the book as it was derived through the book's translations, namely, the extraction of those urban structures of the city of Baghdad, which were of great importance in the religious, cultural, economic and social life at that time, The important link that reflected the development of the Islamic city in general and Baghdad in particular, as he addressed such urban facilities through the translations of the book that did not offer the outline or information about those facilities, but only the name only, and here lies the difficulty in addressing Such as T. As subjects because they need the most accurate analysis of facilities t

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Publication Date
Wed Jan 01 2020
Journal Name
Research Journal Of Pharmacy And Technology
<i>Insilico</i> and <i>in vitro</i> Approach for Design, Synthesis, and Anti-proliferative Activity of Novel Derivatives of 5-(4-Aminophenyl)-4-Substituted Phenyl-2, 4-Dihydro-3<i>H</i>-1, 2, 4-Triazole-3-Thione
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Publication Date
Sat Sep 23 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Construction and Study of Amine Electrodes Based on Membranes Containing Sulfonic Compounds as Active Materials with Different Plasticizers in PVC Matrix Membranes
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Several  amine  liquid selective  electrodes  were prepared based on

two  active   materials,   phenol  sulfonic   acid  and   l ,2-dihydroxy-3,5- disulfonic  acid   disodium   salt   with  several   plasticizers,  di-n-butyl phthalate(ORPH),  tri-n-butyl   phosphate   (TBP)   and  a-nitro   phenyl octyl  ether   (NPOE).   Electrode   parameters   were  studied   including, concentration range,  detection  limit,  slope,  life  time,  response  time and  

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Publication Date
Thu Jun 01 2023
Journal Name
Iraqi Journal Of Physics
D-Shaped Photonic Crystal Fiber Toxic Metal Ions (Arsenic) Sensor Based on Surface Plasmon Resonance
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In this work, a Photonic Crystal Fiber (PCF) sensor based on the Surface Plasmon Resonance (SPR) technology was proposed. A thin layer of gold (Au) was deposited on a D-shaped Photonic Crystal Fiber (PCF), which was coated with plasmonic chemically stable gold material with a thickness of 40nm. The performance parameters like sensitivity including wavelength sensitivity and amplitude sensitivity and resolution were evaluated by simulation using COMSOL software. The proposed sensor was created by using the finite element approach, it is numerically examined. The results show that the surface of D-shaped Photonic Crystal Fiber coated with Au behaves as a sensor to detect the refractive index (IR) of toxic metal ions. The impacts of the str

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