Objectives: To assess the changes in blood vessel stiffness and digital pulse wave amplitude because of flowmediateddilatation, and to explore how these two variables change when endothelial dysfunction isexperimentally induced.Method: The experimental study was conducted at the departments of physiology at the College of Medicine,Mustansiriyah University, and the College of Medicine, Al-Iraqia University, Baghdad, Iraq, from October 14, 2021, toMay 31, 2022, and comprised healthy young males who were subjected to the flow-mediated dilatation techniqueon the left brachial artery. Pulse transit time and the amplitude of the digital pulse wave were measured duringreactive hyperaemia for 2.5 minutes from the left middle finger using a piezoelectric pressure sensor and asimultaneous Lead I electrocardiogram. Endothelial dysfunction (ED) was induced by oscillatory and retrogradeshear rates. The correlation between variables was calculated in Excel running on the Windows operating system.Results: There were 10 second-year medical students with mean age 22±0 years and mean body mass index25.7±4.8kg/m2. During reactive hyperaemia, pulse transit time was significantly increased by 3-5% in both normalendothelium and experimentally induced endothelial dysfunction relative to the pre-occluded artery, and thedifference was not significant (p>0.05). Digital pulse wave amplitude increased significantly in normal endotheliumrelative to the pre-occluded artery (p<0.05), but not in experimentally-induced endothelial dysfunction (p>0.05).Conclusion: The pulse transit time and digital pulse wave amplitudes of the photo plethysmography signal may beused to detect changes in vessel wall diameter and tone throughout the reactive hyperaemia process. Digital pulsewave amplitude was better able to detect experimentally-induced endothelial dysfunction, as assessed by the flowmediateddilatation protocol, than pulse transit time.Key Words: Hyperemia, Brachial Artery, Dilatation, Plethysmography, Electrocardiography, Pulse Wave,Endothelium, Running
The expression of the Proprotein Convertase Subtilisin/Kexin Type 9 gene (PCSK9) is inextricably related to lipid levels and a risk of atherosclerotic coronary artery disease (ASCAD). The present study aims to measure the quantity of PCSK9 gene expression and the effect of methylation on its expression level taking part in the pathogenesis of acute coronary artery disorder.
A current study included 150 subjects from the Iraqi population, 100 ASCAD patients and 50 healthy controls. The concentration of PCSK9 in each serum sample was determined by the ELISA technique, the expression levels of the PCSK9 gene in whole blood were estimated by RT-qPCR – Quantitative Reverse Transcription PCR method, and DNA
... Show MoreIn modern technology, the ownership of electronic data is the key to securing their privacy and identity from any trace or interference. Therefore, a new identity management system called Digital Identity Management, implemented throughout recent years, acts as a holder of the identity data to maintain the holder’s privacy and prevent identity theft. Therefore, an overwhelming number of users have two major problems, users who own data and third-party applications will handle it, and users who have no ownership of their data. Maintaining these identities will be a challenge these days. This paper proposes a system that solves the problem using blockchain technology for Digital Identity Management systems. Blockchain is a powerful techniqu
... Show MoreThrough this article, we studied the peristaltic motion of “Hyperbolic Tangent” fluid in the geometry of curvature channel by using the analysis of large wavelength and less of Reynolds number. The matter has controlled mathematically by the partial differential equations of continuity, motion, heat transfer. In the study, we used the impact of radial magnetic force. The obtained coupled non-linear equations of above equations have solved by an approximation technical. Locked formula solutions of the stream function, axial velocity, heat function has evaluated. The influence of curvature is analysed and took it into account. The impact of sundry variables on the inflow features ha
A vital instrument to foster the long-term goal of high-quality education has developed in the form of digital technologies. The educational system has been found to be significantly impacted by these technologies. The recent COVID- Pandemic has strengthened the legitimacy of using digital tools in education. The entire educational system has undergone a paradigm shift as a result of these digital technologies. Along with sharing knowledge, it also serves as a mentor, an assessor, and a co-creator of information. Students' lives have been simpler as a result of educational technology advancements. Nowadays, students prepare presentations and projects utilizing a variety of software and tools rather than pen and paper. The weig
... Show MoreThis paper proposed a new approach for an underwater visible light communication (UVLC) system using MIMO (2Tx/2Rx) technology. The BER performance, Q-factor, and data rate of the UVLC system are looked at in coastal waters of the Jerov type (J1C, J3C, J5C, J7C, and J9C). The applied system takes into account the angles ranging from 0 to 15° and 45°. The results indicated that 32-PPM outperformed other modulation techniques.
Many pharmaceutical molecules have solubility problems that until yet consist a hurdle that restricts their use in the pharmaceutical preparations. Lacidipine (LCDP) is a calcium-channel blocker with low aqueous solubility and bioavailability.
Lipid dosage forms are attractive delivery systems for such hydrophobic drug molecules. Nanoemulsion (NE) is one of the popular methods that has been used to solve the solubility problems of many drugs. LCDP was formulated as a NE utilizing triacetin as an oil phase, tween 80 and tween 60 as a surfactant and ethanol as a co-surfactant. Nine formulas were prepared, and different tests performed to ensure the stability of the NEs, such as thermodyna
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